{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:04:54Z","timestamp":1792807494006,"version":"4.5.0"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>STRIDE II guidelines recognise endoscopic healing as a main therapeutic target in Crohn's disease (CD). Nevertheless, transmural healing (TH) could reduce the risk of long\u2010term complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess the impact of intestinal ultrasound (IUS) TH on CD long\u2010term among patients with endoscopic healing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>We conducted a prospective study of consecutive patients with CD who underwent colonoscopy with endoscopic healing (CDEIS &lt;\u20094) and IUS. IUS TH was defined by a bowel wall thickness &lt;\u20093\u2009mm without colour Doppler signal. The primary endpoint was CD relapse (drug intensification, initiation of steroid, CD\u2010related hospitalization or surgery, luminal stricture\/fistula or perianal CD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 93 patients. IUS TH was observed in 73%. No difference in median IBD\u2010risk score was observed among patients with and without IUS TH (22 (IQR 7\u201341) vs. 30 (IQR 13\u201355);\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.15). After a median follow\u2010up of 22.5\u2009months (IQR 19.3\u201323.7), the cumulative risk of relapse was significantly lower among patients with IUS healing (17% vs. 48%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007). The benefit of TH remained when considering only patients with complete endoscopic healing (CDEIS\u2009=\u20090) (12\u2010month relapse rate, 2% vs. 33%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03). The risk of CD\u2010related hospitalization (3% vs. 16%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04) and perianal CD (3% vs. 16%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04) were significantly lower among patients with IUS healing. In multivariate analysis, the absence of TH remained the only independent factor associated with CD relapse (hazard ratio 2.6 (1.1\u20136.2);\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>IUS TH was associated with improved long\u2010term outcomes with lower risks of CD relapse, hospitalization, and perianal CD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.70479","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T11:26:27Z","timestamp":1764674787000},"page":"992-999","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Intestinal Ultrasound Transmural Healing Was Associated With Improved Long\u2010Term Outcomes Among Patients With Endoscopic Remission: Results of a Prospective Study"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7790-3919","authenticated-orcid":false,"given":"Clara","family":"Yzet","sequence":"first","affiliation":[{"name":"Gastroenterology Unit Amiens University Hospital  Amiens France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Am\u00e9lie","family":"Plancke","sequence":"additional","affiliation":[{"name":"Radiology Unit Amiens University Hospital  Amiens France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck","family":"Brazier","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit Amiens University Hospital  Amiens France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucien","family":"Grados","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit Amiens University Hospital  Amiens France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise","family":"Derval","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit Amiens University Hospital  Amiens France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Ghilardi","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit Amiens University Hospital  Amiens France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Momar","family":"Diouf","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Amiens University Hospital  Amiens France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrien","family":"Ollier","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Amiens University Hospital  Amiens France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2337-2902","authenticated-orcid":false,"given":"Mathurin","family":"Fumery","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit Amiens University Hospital  Amiens France"},{"name":"Peritox, UMR\u2010I01 Universit\u00e9 de Picardie Jules Verne  Amiens 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