{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T02:55:50Z","timestamp":1776308150695,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["825694"],"award-info":[{"award-number":["825694"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003825","name":"Magyar Tudom\u00e1nyos Akad\u00e9mia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003825","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Gut barrier dysfunction contributes to acute decompensation (AD) of cirrhosis progression but, it is not acknowledged in severity or prognostic scores due to a lack of appropriate assessment tools.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>We investigated serum villin\u20101 (VIL1), an epithelial brush\u2010border associated actin\u2010binding protein, as a non\u2010invasive marker for gut injury and prognosis in AD cirrhosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Serum VIL1 was measured in 338 cirrhosis patients (discovery\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009130, validation\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009208, including acute\u2010on\u2010chronic liver failure [ACLF]) from MICROB\u2010PREDICT cohorts and 50 healthy controls (HC). Duodenal biopsies (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200949 patients,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200911 HC) were assessed for tissue VIL1 via immunohistochemistry. Serum cytokine profiling linked serum VIL1 levels to systemic inflammation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared to HC, both serum and tissue VIL1 levels were lower in stable AD patients. However, serum VIL1 progressively increased with AD severity, peaking in ACLF. Serum VIL1 was associated with 90\u2010day mortality (AUROC: 0.721,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001; similar to MELD: 0.722,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). A cut\u2010off &gt;\u200912.79\u2009ng\/mL enhanced the prognostic accuracy provided by severe disease stage, defined as CLIF\u2010C AD score \u2265\u200950 or ACLF (low VIL1: 17.5% vs. high VIL1: 53.6% mortality). This threshold was associated with increased systemic inflammation, suggesting enhanced bacterial translocation. VIL1 was an independent predictor of 90\u2010day mortality (HR: 2.52, CI: 1.648\u20133.848,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) in Cox regression. All findings were confirmed in the validation cohort.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Serum VIL1 is a non\u2010invasive indicator of gut barrier damage and short\u2010term mortality in AD cirrhosis. Incorporating VIL1 assessment into risk stratification methods improves prognostic accuracy by capturing an essential, yet previously overlooked component of disease progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.70481","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T05:52:22Z","timestamp":1764827542000},"page":"1018-1032","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Serum Villin\u20101\u2014A Novel Marker of Gut Barrier Damage in Acutely Decompensated Cirrhosis: A Cohort Study and Validation"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1335-5498","authenticated-orcid":false,"given":"David","family":"Tornai","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine University of Debrecen  Debrecen Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boglarka","family":"Balogh","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine University of Debrecen  Debrecen Hungary"},{"name":"Kalman Laki Doctoral School of Biomedical and Clinical Sciences, Faculty of Medicine University of Debrecen  Debrecen Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aniko","family":"Csillag","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine University of Debrecen  Debrecen Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andras","family":"Budai","sequence":"additional","affiliation":[{"name":"Department of Pathology, Forensic and Insurance Medicine, Faculty of Medicine Semmelweis University  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andras","family":"Kiss","sequence":"additional","affiliation":[{"name":"Department of Pathology, Forensic and Insurance Medicine, Faculty of Medicine Semmelweis University  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Antal\u2010Szalmas","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Faculty of Medicine University of Debrecen  Debrecen Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabor","family":"Mehes","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine University of Debrecen  Debrecen Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukacs","family":"Barath","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine University of Debrecen  Debrecen Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamas","family":"Tornai","sequence":"additional","affiliation":[{"name":"Institute of Pancreatic Diseases Semmelweis University  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Istvan","family":"Tornai","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine University of Debrecen  Debrecen Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsuzsanna","family":"Vitalis","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine University of Debrecen  Debrecen Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nora","family":"Sipeki","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine University of Debrecen  Debrecen Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamas","family":"Dinya","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine University of Debrecen  Debrecen Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Attila","family":"Enyedi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine University of Debrecen  Debrecen Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian A.","family":"Rosenberger","sequence":"additional","affiliation":[{"name":"Department for Proteomics and Signal Transduction Max\u2010Planck Institute of Biochemistry  Martinsried Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wim","family":"Laleman","sequence":"additional","affiliation":[{"name":"Division of Liver &amp; Biliopancreatic Disorders and Liver Transplantation, Department of Gastroenterology &amp; Hepatology University Hospitals Leuven, KU Leuven  Leuven Belgium"},{"name":"Department of Internal Medicine B University of M\u00fcnster  M\u00fcnster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minneke J.","family":"Coenraad","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferran","family":"Aguilar","sequence":"additional","affiliation":[{"name":"European Foundation for the Study of Chronic Liver Failure (EF CLIF)  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan","family":"Claria","sequence":"additional","affiliation":[{"name":"European Foundation for the Study of Chronic Liver Failure (EF CLIF)  Barcelona Spain"},{"name":"IDIBAPS and CIBERehd Hospital Cl\u00ednic  Barcelona 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