{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T20:21:23Z","timestamp":1793996483318,"version":"4.8.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T00:00:00Z","timestamp":1764460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Obesity and metabolic disease are increasingly prevalent in patients with inflammatory bowel disease (IBD) and can influence disease activity and treatment outcomes. Glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101 RAs) are effective for weight loss and metabolic control, yet their safety and effects in IBD remain uncertain as patients with IBD have been excluded from pivotal trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To systematically evaluate the weight\u2010related, metabolic, IBD\u2010specific, and safety outcomes of GLP\u20101 receptor agonists in adults with IBD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a systematic review according to PRISMA guidelines (PROSPERO CRD42025628850). We searched MEDLINE, Embase, Cochrane Library and\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      to 9 September 2025 for studies evaluating GLP\u20101 RAs in adults with IBD. Primary outcomes were weight\u2010related measures. Secondary outcomes included metabolic parameters, IBD activity, and safety. Risk of bias was assessed using Joanna Briggs Institute (JBI) checklists.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 14 studies of which 13 were retrospective cohort studies. Ten reported significant reductions in body weight, BMI, or percent weight loss. Four demonstrated improvements in metabolic markers, including decreased haemoglobin A1c and favourable lipid changes. Across multiple datasets, GLP\u20101 RA use was not associated with increased IBD exacerbations. Several large registries reported reduced risks of corticosteroid use, hospitalisation and surgery among GLP\u20101 RA users. Adverse events were primarily gastrointestinal, consistent with non\u2010IBD populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>GLP\u20101 RAs appear to be well tolerated in patients with IBD, with observational evidence suggesting potential associations with improved weight, metabolic, and disease\u2010related outcomes. Prospective, IBD\u2010specific studies are required to confirm safety, clarify mechanisms, and define optimal patient selection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.70485","type":"journal-article","created":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T14:09:51Z","timestamp":1764511791000},"page":"17-39","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Systematic Review: Efficacy, Safety and Metabolic Outcomes of GLP\u20101 Receptor Agonists in Inflammatory Bowel Disease"],"prefix":"10.1111","volume":"63","author":[{"given":"Brooke","family":"Maracle","sequence":"first","affiliation":[{"name":"IBD Unit, Division of Gastroenterology and Hepatology, Department of Medicine University of Calgary Cumming School of Medicine  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Quan","sequence":"additional","affiliation":[{"name":"Cumming School of Medicine University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Hamilton","sequence":"additional","affiliation":[{"name":"IBD Unit, Division of Gastroenterology and Hepatology, Department of Medicine University of Calgary Cumming School of Medicine  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asma","family":"Shaikh","sequence":"additional","affiliation":[{"name":"Cumming School of Medicine University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepan","family":"Hazra","sequence":"additional","affiliation":[{"name":"Cumming School of Medicine University of Calgary  Calgary Alberta 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Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00eblle","family":"St\u2010Pierre","sequence":"additional","affiliation":[{"name":"IBD Unit, Division of Gastroenterology and Hepatology, Department of Medicine University of Calgary Cumming School of Medicine  Calgary Alberta Canada"},{"name":"Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575\u2010020\u201000360\u2010x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2016.181"},{"key":"e_1_2_10_4_1","first-page":"11","article-title":"The Impact of Obesity on Inflammatory Bowel Disease","volume":"11","author":"Kaazan 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