{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:20:42Z","timestamp":1791415242904,"version":"4.3.3"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cholestasis is a frequent phenomenon in patients with burn injury and linked with impaired outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To explore longitudinal trajectories of cholestasis and validate the proposed definition of burn\u2010associated cholestasis (BAC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>532 patients admitted to an intensive care unit (ICU) for burn injury over a 10\u2010year timeframe were included in this single\u2010center, retrospective cohort study. Burn severity, ICU treatment, and laboratory parameters were longitudinally collected from admission to discharge or death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Median total body surface area burned was 15% and 234 patients (44%) had severe burn (\u2265\u200920%). 118 patients (22%) met the proposed criteria of BAC while 41%, 30%, and 68% developed elevated alkaline phosphatase, bilirubin, and gamma\u2010glutamyl transferase, respectively. BAC was associated with burn severity, ketamine use, mechanical ventilation, and parenteral nutrition, and 85% of cases occurred in patients exposed to ketamine, mechanical ventilation, and parenteral nutrition. Hyperbilirubinemia (\u2265\u20092\u00d7 upper\u2010limit\u2010of\u2010normal, i.e., BAC subtype B\/C) was independently associated with mortality adjusting for burn severity, critical illness severity, and ICU\u2010specific treatment. However, bilirubin alone provided better discrimination, especially regarding excess deaths after \u2265\u20097\u2009days (Harrel's C: 0.80\u20130.83). Concordant increases in bilirubin and alkaline phosphatase\/gamma\u2010glutamyl transferase allow for early identification of an at\u2010risk population. Developing hyperbilirubinemia until Day 14 identified a subgroup with severely impaired prognosis (survival at 90\u2009days: 46% vs. 95%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cholestasis is frequent following burn injury. Prognosis is determined by bilirubin dynamics independently of disease and burn severity. Hyperbilirubinemia is associated with excess mortality \u2265\u20097\u2009days after surviving burn injury.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.70505","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T09:54:10Z","timestamp":1768384450000},"page":"1140-1150","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Characterisation and Prognostic Implication of Cholestasis After Burn Injury"],"prefix":"10.1111","volume":"63","author":[{"given":"Lorenz","family":"Semmler","sequence":"first","affiliation":[{"name":"Department of Plastic, Reconstructive and Aesthetic Surgery Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0411-166X","authenticated-orcid":false,"given":"Georg","family":"Semmler","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and 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