{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T06:30:06Z","timestamp":1788330606274,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ehlers\u2013Danlos syndrome (EDS) comprises inherited connective tissue disorders characterised by joint hypermobility, skin hyperextensibility and tissue fragility. It links to systemic comorbidities, including gastrointestinal (GI) disorders, but hitherto large\u2010scale data remain limited. We aimed to evaluate the prevalence of GI, systemic and psychological comorbidities in EDS patients versus propensity score\u2010matched controls, using a comprehensive research network database.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>This was a retrospective, propensity\u2010matched analysis (2005\u20132023) utilising the TriNetX network. We identified EDS patients (excluding Marfan's syndrome). Propensity score matching (1:1) generated balanced cohorts for age, sex and baseline characteristics. Comorbidities were analysed via prevalence rates and odds ratios (ORs) with 95% confidence intervals (CIs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Matched cohorts included 59,128 pairs. Among GI disorders, gastroesophageal reflux disease was most common in EDS (18.4%, OR 1.5, 95% CI 1.4\u20131.5,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), followed by constipation (12.4%, OR 1.8, 95% CI 1.7\u20131.9,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), irritable bowel syndrome (7.3%, OR 2.6, 95% CI 2.5\u20132.8,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and gastroparesis (4.7%, OR 8.2, 95% CI 7.3\u20139.2,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Psychiatric conditions showed heightened prevalence of anxiety (26.1%, OR 1.8, 95% CI 1.7\u20131.8,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and depression (18.7%, OR 1.3, 95% CI 1.2\u20131.3,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Systemic comorbidities included postural orthostatic tachycardia syndrome (13.2%, OR 899.7, 95% CI 483.8\u20131673.0,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), chronic pain (7.9%, OR 7.0, 95% CI 6.4\u20137.6,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), migraines (19.7%, OR 2.5, 95% CI 2.4\u20132.6,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and fibromyalgia (9.5%, OR 1.7, 95% CI 1.6\u20131.8,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>EDS patients exhibit heightened risk for GI, systemic and psychological comorbidities, highlighting the importance of multidisciplinary approaches for effective management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.70506","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T13:35:00Z","timestamp":1766496900000},"page":"1151-1161","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Comprehensive Risk Profile of Gastrointestinal and Extra Articular Comorbidities in Ehlers\u2013Danlos Syndrome: A Propensity\u2010Matched Analysis of 118,256 Individuals"],"prefix":"10.1111","volume":"63","author":[{"given":"Saqr","family":"Alsakarneh","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5938-4315","authenticated-orcid":false,"given":"Omar","family":"Al Ta\u2019ani","sequence":"additional","affiliation":[{"name":"Department of Medicine Allegheny General Hospital  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud Y.","family":"Madi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Saint Louis University School of Medicine  St Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wing\u2010Kin","family":"Syn","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Saint Louis University School of Medicine  St Louis Missouri USA"},{"name":"Department of Physiology, Faculty of Medicine and Nursing University of the Basque Country UPV\/EHU  Bilbao Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6248-7203","authenticated-orcid":false,"given":"James K.","family":"Ruffle","sequence":"additional","affiliation":[{"name":"Queen Square Institute of Neurology University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qasim","family":"Aziz","sequence":"additional","affiliation":[{"name":"Wingate Institute of Neurogastroenterology Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1902-2640","authenticated-orcid":false,"given":"Adam D.","family":"Farmer","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Saint Louis University School of Medicine  St Louis Missouri USA"},{"name":"Wingate Institute of Neurogastroenterology Queen Mary University of London  London 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