{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:32:34Z","timestamp":1792510354205,"version":"4.5.0"},"reference-count":50,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background &amp; Aims<\/jats:title>\n                    <jats:p>The diagnosis and follow\u2010up of eosinophilic oesophagitis (EoE) currently rely on repeated upper endoscopies (EGD) with biopsies, which are invasive, resource\u2010intensive and environmentally costly. Non\u2010invasive biomarkers for EoE are needed. We investigated the role of blood eosinophils and lymphocytes in the management of EoE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a prospective study conducted at four EoE referral centres. Consecutive adults undergoing EGD with biopsies for known or suspected EoE were enrolled. Based on oesophageal peak eosinophil count (PEC) and clinical history, patients were divided into EoE (histologically active or in remission) and non\u2010EoE dysphagia (NED). Prior to the EGD, a full blood count was obtained. Clinical, endoscopic and histologic findings were recorded. Receiver operating characteristic curve analysis was used to assess the predictive ability of blood biomarkers (AUC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We enrolled 209 patients (123 EoE and 86 NED). For the diagnosis of EoE, an absolute eosinophil count (AEC) of 155 eosinophils\/mm\n                      <jats:sup>3<\/jats:sup>\n                      had an AUC of 85%. For the assessment of histological disease activity, an AEC of 325 eosinophils\/mm\n                      <jats:sup>3<\/jats:sup>\n                      had an AUC of 70.5% for the identification of histological remission following treatment. AEC showed a positive correlation with PEC on histology and the EoE endoscopic reference score with Spearman's Rho of 0.4 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Eosinophil absolute and relative counts in the peripheral blood could be used in the initial assessment of patients presenting with dysphagia to accurately differentiate EoE from NED and to predict histological remission of EoE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.70524","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T14:21:15Z","timestamp":1767795675000},"page":"1256-1264","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Blood Eosinophils Are Accurate Biomarkers for the Management of Eosinophilic Oesophagitis: Prospective, Multi\u2010Centre Study"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6985-5301","authenticated-orcid":false,"given":"Pierfrancesco","family":"Visaggi","sequence":"first","affiliation":[{"name":"Gastroenterology Unit, Department of Translational Research and New Technologies in Medicine and Surgery University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaia","family":"Pellegatta","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Digestive Endoscopy IRCCS Humanitas Research Hospital  Rozzano Italy"},{"name":"Department of Biomedical Sciences Humanitas University, Pieve Emanuele  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0532-3135","authenticated-orcid":false,"given":"Stefano","family":"Siboni","sequence":"additional","affiliation":[{"name":"Division of General and Emergency Surgery IRCCS Policlinico San Donato, University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria","family":"Maniero","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Surgery, Oncology and Gastroenterology University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio Del","family":"Corso","sequence":"additional","affiliation":[{"name":"Institute of Information Science and Technologies \u2018A. Faedo\u2019, National Research Council of Italy (CNR)  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Solinas","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Department of Translational Research and New Technologies in Medicine and Surgery University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Mitilini","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Department of Translational Research and New Technologies in Medicine and Surgery University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Testi","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Department of Translational Research and New Technologies in Medicine and Surgery University of Pisa  Pisa 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Humanitas Research Hospital  Rozzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Sozzi","sequence":"additional","affiliation":[{"name":"Division of General and Emergency Surgery IRCCS Policlinico San Donato, University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Piazza","sequence":"additional","affiliation":[{"name":"Institute of Clinical Physiology, National Research Council  Pisa Italy"},{"name":"Biochemistry Unit, Department of Biology University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delio","family":"Stefani Donati","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Department of Translational Research and New Technologies in Medicine and Surgery University of Pisa  Pisa 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