{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:06:31Z","timestamp":1791651991961,"version":"4.3.4"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The UK has adopted faecal immunochemical testing (FIT) to triage symptomatic colonoscopy referrals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Quantify diagnostic yield and independent effects of FIT, age, sex and symptoms on polyp and cancer detection in symptomatic colonoscopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Nationwide analysis of prospectively collected colonoscopy reports (June 2023\u2013August 2025) from the National Endoscopy Database. Symptomatic procedures, including iron\u2010deficiency anaemia (IDA), were identified and diagnostic yields calculated. Mixed\u2010effects logistic regression estimated adjusted odds ratios (aORs) with age, sex, symptom group and FIT. Post\u2010estimation margins modelled cancer yield by age, FIT and symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Analysis of 447,109 symptomatic colonoscopies, with FIT recorded in 202,219 (45.2%). Overall cancer yield was 1.9% (95% CI, 1.8\u20131.9).<\/jats:p>\n                    <jats:p>Cancer yield was 3.8% (95% CI, 3.7\u20133.9) in FIT \u2265\u200910, including 2.5% (95% CI, 2.3\u20132.7) at age 40\u201349 and 0.6% (95% CI, 0.5\u20130.7) at age 16\u201339; yield in FIT &lt;\u200910 was 0.3% (95% CI, 0.2\u20130.3).<\/jats:p>\n                    <jats:p>\n                      FIT concentration showed a strong, graded association with cancer risk, weaker association with large polyps, and minimal association with small polyps. IDA was associated with higher cancer risk versus rectal bleeding (aOR 2.2, 95% CI, 2.0\u20132.3;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01).\n                    <\/jats:p>\n                    <jats:p>With FIT &lt;\u200910, cancer yield exceeded 1% only in IDA patients aged &gt;\u200980 and remained &lt;\u20090.5% otherwise. A model combining FIT, age, and IDA detected &gt;\u200994% of cancers while reducing colonoscopy demand by &gt;\u200940%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This national analysis demonstrates the superiority of FIT\u2010based triage over symptom\u2010based referral, with FIT \u2265\u200910 identifying high\u2010risk patients, including those aged 40\u201349, while FIT &lt;\u200910 indicated very low risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.70537","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T09:14:38Z","timestamp":1769591678000},"page":"1297-1305","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Real\u2010World Performance of\n                    <scp>FIT<\/scp>\n                    Triage for Symptomatic Colonoscopy: Analysis of the\n                    <scp>UK<\/scp>\n                    National Endoscopy Database (\n                    <scp>NED<\/scp>\n                    )"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4329-8842","authenticated-orcid":false,"given":"David","family":"Beaton","sequence":"first","affiliation":[{"name":"Northumbria NHS Foundation Trust  North Shields UK"},{"name":"Population Health Sciences Institute, Newcastle University Centre for Cancer, Newcastle University  Newcastle\u2010upon\u2010Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4779-4632","authenticated-orcid":false,"given":"Mahmoud","family":"Mohamed","sequence":"additional","affiliation":[{"name":"North Tees and Hartlepool NHS Foundation Trust  Stockton\u2010on\u2010Tees UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9515-1722","authenticated-orcid":false,"given":"Linda","family":"Sharp","sequence":"additional","affiliation":[{"name":"Population Health Sciences Institute, Newcastle University Centre for Cancer, Newcastle University  Newcastle\u2010upon\u2010Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0619-0023","authenticated-orcid":false,"given":"Keith","family":"Pohl","sequence":"additional","affiliation":[{"name":"Torbay and South Devon NHS Foundation Trust  Torquay UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9507-0295","authenticated-orcid":false,"given":"Matthew","family":"Rutter","sequence":"additional","affiliation":[{"name":"Population Health Sciences Institute, Newcastle University Centre for Cancer, Newcastle University  Newcastle\u2010upon\u2010Tyne UK"},{"name":"North Tees and Hartlepool NHS Foundation Trust  Stockton\u2010on\u2010Tees UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_11_3_1","unstructured":"Cancer Research UK \u201cBowel cancer mortality statistics \u201d(2015) https:\/\/www.cancerresearchuk.org\/health\u2010professional\/cancer\u2010statistics\/statistics\u2010by\u2010cancer\u2010type\/bowel\u2010cancer\/mortality."},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.48.6.812"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301848"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2007\/642959"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.18003"},{"key":"e_1_2_11_8_1","unstructured":"NICE \u201cQuantitative faecal immunochemical tests to guide referral for colorectal cancer in primary care \u201d(2017) https:\/\/www.nice.org.uk\/guidance\/dg30."},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2022-327985"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2021-324856"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3399\/bjgp18X699413"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3399\/BJGP.2024.0358"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640619841539"},{"key":"e_1_2_11_14_1","unstructured":"NED\u2014National Endoscopy Database 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