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We aimed to evaluate the association of steatosis\u2010polygenic risk score (PRS) with HCC following direct\u2010acting antiviral (DAA) therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study utilised data from the Taiwan Precision Medicine Initiative, including adults treated with DAAs for HCV. Patients with treatment failure, hepatitis B virus co\u2010infection, significant alcohol use, or HCC diagnosis prior to sustained virological response at 24\u2009weeks were excluded. All participants underwent genotyping, with PRS\u20105 being used to quantify genetic risk. We evaluated the association between PRS\u20105 and the risk of incident HCC using restricted cubic spline analysis with Cox proportional hazards models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The cohort included 420 patients (median age 67.0\u2009years; 46.9% male). The 5\u2010year cumulative incidence of HCC in PRS\u20105\u2009\u2265\u20090.66 group was higher than PRS\u20105\u2009&lt;\u20090.66 group (23.97%, 95% confidence interval (CI) 7.15%\u201340.79% vs. 8.89%, 95% CI 5.56%\u201312.23%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014). In multivariable regression, PRS\u20105\u2009\u2265\u20090.66 (aSHR 3.59, 95% CI 1.69\u20137.63;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), body weight index &gt;\u200924\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      (aSHR 2.68, 95% CI 1.24\u20135.78;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012), and Fibrosis\u20104 index &gt;\u20093.25 (aSHR 4.58, 95% CI 2.20\u20139.53;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) were independently associated with HCC occurrence. Subgroup analysis supported the predictive value of PRS\u20105 in almost all patient subgroups, including Fibrosis\u20104 index &lt;\u20093.25 and non\u2010cirrhosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PRS\u20105 is independently associated with increased HCC risk after HCV eradication, supporting its role in personalised HCC surveillance strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.70566","type":"journal-article","created":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T14:40:18Z","timestamp":1770561618000},"page":"1398-1409","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Liver Steatosis\u2010Related Polygenic Risk Score Predicts Hepatocellular Carcinoma Risk After Hepatitis C Virus Eradication"],"prefix":"10.1111","volume":"63","author":[{"given":"Yu\u2010Sheng","family":"Lin","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine Taichung Veterans General Hospital  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying\u2010Cheng","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine Taichung Veterans General Hospital  Taichung Taiwan"},{"name":"Department of Post\u2010Baccalaureate Medicine, College of Medicine Chung Hsing University  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun\u2010Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Post\u2010Baccalaureate Medicine, College of Medicine Chung Hsing University  Taichung Taiwan"},{"name":"Cardiovascular Center Taichung Veterans General Hospital  Taichung 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