{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T15:33:38Z","timestamp":1790091218942,"version":"4.0.1"},"reference-count":43,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T00:00:00Z","timestamp":1772928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T00:00:00Z","timestamp":1772928000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Guidelines recommend considering frailty in the management of older patients with Inflammatory Bowel Disease (IBD). A geriatric assessment is a specific and clinically applicable frailty assessment tool that could potentially predict both adverse outcomes and inform treatment decisions in older patients with IBD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To examine the association of frailty with hospitalisations and mortality in older patients with IBD during 18\u2009months follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a prospective, multicentre cohort study in older patients (age \u2265\u200965\u2009years) with IBD. Frailty was measured using a geriatric assessment, covering five domains of functioning. Deficits in geriatric assessment reflect the level of frailty and were defined as: no deficits (0\u20131 impaired domains), moderate deficits (2\u20133 impaired domains) and severe deficits (4\u20135 impaired domains). Follow\u2010up was aimed at after 18\u2009months. Outcomes were all\u2010cause, acute and IBD\u2010related hospitalisation and mortality. Analyses were adjusted for age, sex and biochemical disease activity (C\u2010reactive protein \u2265\u200910\u2009mg\/L and\/or faecal calprotectin \u2265\u2009250\u2009\u03bcg\/g).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 405 patients with median age 70\u2009years, 160 (39.5%) had 2\u20133 geriatric deficits, 32 (7.9%) had 4\u20135 geriatric deficits. Severe deficits were independently associated with both all\u2010cause (adjusted hazard ratio [aHR] 3.46, 95% confidence interval [CI] 1.67\u20137.16) and acute hospitalisations (aHR 3.45, 95% CI 1.59\u20137.51). Specifically, an impaired somatic domain was independently associated with all\u2010cause hospitalisations (aHR 2.13, 95% CI 1.32\u20133.42) and acute hospitalisations (aHR 2.43, 95% CI 1.40\u20134.22).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Frailty, reflected by severe deficits in geriatric assessment, is independently associated with all\u2010cause and acute hospitalisations in older patients with IBD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.70594","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:57:16Z","timestamp":1772989036000},"page":"1495-1506","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Frailty Is Associated With All\u2010Cause and Acute Hospitalisations During 18\u2009Months Follow\u2010Up in Older Patients With Inflammatory Bowel Disease"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7776-527X","authenticated-orcid":false,"given":"Anne B.","family":"Fons","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Leiden University Medical Centre  Leiden the Netherlands"},{"name":"Department of Geriatric Medicine Spaarne Gasthuis  Haarlem the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera E. R.","family":"Asscher","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Leiden University Medical Centre  Leiden the Netherlands"},{"name":"Department of Gastroenterology and Hepatology HagaZiekenhuis  The Hague the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rogier J. L.","family":"Stuyt","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology HagaZiekenhuis  The Hague the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Martine C.","family":"Baven\u2010Pronk","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Groene Hart Ziekenhuis  Gouda the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sander","family":"van der Marel","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Haaglanden Medical Centre  The Hague the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rutger J.","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Alrijne Hospital  Leiden and Leiderdorp the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeoffrey J. L.","family":"Haans","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Maastricht University Medical Centre  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9353-5431","authenticated-orcid":false,"given":"Andrea E.","family":"van der Meulen\u2010de Jong","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Leiden University Medical Centre  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon P.","family":"Mooijaart","sequence":"additional","affiliation":[{"name":"Department of Gerontology and Geriatrics Leiden University Medical Centre  Leiden the Netherlands"},{"name":"LUMC Center for Medicine for Older People LUMC  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kees. 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