{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:49:46Z","timestamp":1790668186540,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100014931","name":"Arrowhead Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014931","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients with persistent chylomicronaemia (PC) are at high risk for acute pancreatitis (AP). Plozasiran, a small interfering RNA, reduces hepatic apolipoprotein C\u2010III, significantly lowers triglyceride (TG) levels and reduces risk of AP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess the effect of plozasiran on recurrent AP in patients with severe hypertriglyceridemia and history of pancreatitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PALISADE was an international, multicentre, double\u2010blind, placebo\u2010controlled trial. Patients with extreme hypertriglyceridemia were randomised 2:1:2:1 to receive subcutaneous plozasiran (25\u2010 or 50\u2010mg) or volume\u2010matched placebo, quarterly for 12\u2009months. This post hoc analysis involved participants with a history of at least one prior episode of AP. Primary and alpha\u2010controlled secondary endpoints included the incidence of expert\u2010adjudicated AP and pancreatitis\u2010related hospitalisations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The analysis included 67 participants with median baseline TG &gt;\u200922.6\u2009mmol\/L (2000\u2009mg\/dL). Plozasiran\u2010treated participants experienced a &gt;\u200975% reduction in median TG, with median levels falling below 5.65\u2009mmol\/L (500\u2009mg\/dL). Incident AP occurred in 5 of 22 in the placebo group versus 2 of 45 in the pooled plozasiran group, representing an 83% (HR, 0.17; 95% CI [0.03, 0.87],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.017) reduction in risk for recurrent AP in the plozasiran group. AP severity, hospitalisation rates for abdominal pain, and length of hospital stay were lower in the plozasiran group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Plozasiran significantly lowered circulating TG levels, with substantial reduction in recurrent AP for participants with very severe hypertriglyceridemia and history of AP. Plozasiran is the first therapy to demonstrate a statistically significant reduction in recurrent AP in a prospective randomised trial of patients with familial chylomicronaemia syndrome (FCS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">Clinicaltrials.gov<\/jats:ext-link>\n                      identifier: NCT05089084\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.70623","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T05:20:31Z","timestamp":1775107231000},"page":"1236-1245","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinical Trial: Plozasiran Prevents Recurrent Pancreatitis in Adults With Very Severe Hypertriglyceridemia\u2014Results of a Post Hoc Analysis of the Phase 3\n                    <scp>PALISADE<\/scp>\n                    Study"],"prefix":"10.1111","volume":"63","author":[{"given":"Rohit","family":"Loomba","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine University of California at San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2412-9541","authenticated-orcid":false,"given":"Enrique","family":"de\u2010Madaria","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Dr. Balmis General University Hospital\u2010ISABIAL  Alicante Spain"},{"name":"Department of Clinical Medicine Miguel Hernandez University  Elche Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Afghani","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Johns 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