{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:30:40Z","timestamp":1791304240838,"version":"4.3.1"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sarcopenia is associated with increased mortality in patients awaiting liver transplant (LT), but the impact of sarcopenia on cirrhosis progression remains under\u2010evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We aimed to explore the relationship between sarcopenia and the risk of cirrhosis progression, mortality and hospitalisation in compensated and decompensated cirrhosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sarcopenia was measured using the skeletal muscle index (SMI) obtained from abdominal CT imaging at the 3rd lumbar vertebra (L3). Progression of cirrhosis was defined by an increase in clinical stage from baseline using the D'Amico classification. Factors associated with progression or death, death alone and hospitalisation were evaluated with univariate and multivariate Cox regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      One thousand six hundred and twenty\u2010four adult patients with cirrhosis from five centres across Europe, North America and Asia were included. Mean age was 54\u2009\u00b1\u20099\u2009years, 26% of patients were female, 31% had compensated disease and mean MELD\u2010Na was 15\u2009\u00b1\u20097. With separate analyses for compensated and decompensated cirrhosis, sarcopenia was independently associated with the risk of progression or death (aHR 1.43, 95% CI 1.14\u20131.79,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002) and death alone (aHR 1.55, 95% CI 1.19\u20132.03,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) only in decompensated cirrhosis. Sarcopenia was independently associated with unplanned hospitalisation in\n                      <jats:italic>both<\/jats:italic>\n                      compensated (aHR 1.70, 95% CI 1\u201315\u20102.51,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.010) and decompensated cirrhosis (aHR 1.32, 95% CI 1.08\u20131.63,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Sarcopenia was independently associated with cirrhosis progression or death and death alone in decompensated cirrhosis. Future studies are needed to evaluate the possibility of slowing cirrhosis disease progression by reversing or preventing sarcopenia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.70636","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T03:14:13Z","timestamp":1774926853000},"page":"36-49","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Sarcopenia Is Associated With Mortality and Progression of Cirrhosis in Decompensated but Not Compensated Disease\u2014A Multicentre Study"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0486-0174","authenticated-orcid":false,"given":"Puneeta","family":"Tandon","sequence":"first","affiliation":[{"name":"Division of Gastroenterology (Liver Unit), University of Alberta  Edmonton Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology (Liver Unit), University of Alberta  Edmonton Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moon Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University Wonju College of Medicine  Wonju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart","family":"Van Hoek","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daphne","family":"Bot","sequence":"additional","affiliation":[{"name":"Department of Dietetics Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen L. A.","family":"van Vugt","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of HPB &amp; Transplant Surgery University of Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8307-6999","authenticated-orcid":false,"given":"Berend","family":"Beumer","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of HPB &amp; Transplant Surgery, Erasmus MC Transplant Institute, Erasmus MC University Medical Centre Rotterdam  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Ijzermans","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of HPB &amp; Transplant Surgery, Erasmus MC Transplant Institute, Erasmus MC University Medical Centre Rotterdam  Rotterdam the 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