{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T21:49:35Z","timestamp":1782510575782,"version":"3.54.5"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>In 2024, a novel high\u2010resolution manometry (HRM) metric termed the Milan Score was introduced to quantify anti\u2010reflux barrier disruption and estimate the probability of pathologic gastroesophageal reflux disease (GERD). This composite score incorporates oesophagogastric junction (EGJ) barrier metrics, oesophageal motor function and response to the straight leg raise (SLR) manoeuvre. Prior validations relied on acid exposure time (AET)\u2009&gt;\u20096% on 24\u2010h pH\u2010impedance studies, making the outcome susceptible to day\u2010to\u2010day variability. The aim of this study is to validate the effectiveness of the Milan Score in predicting GERD using 96\u2010h wireless pH\u2010monitoring.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data from consecutive adults with GERD symptoms undergoing HRM and 96\u2010h wireless pH\u2010monitoring (2023\u20132025) at IRCCS Policlinico San Donato (Italy) and Washington University in St. Louis (USA) were retrospectively collected. Milan Score was calculated automatically from HRM metrics. pH studies followed Lyon Consensus 2.0 criteria, defining conclusive GERD as AET &gt;\u20096% on \u2265\u20092\u2009days. Diagnostic performance was evaluated by receiver operator characteristics (ROC) analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the 90 included patients (age 54\u2009years, 59% females, BMI 25\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ), 48 had conclusive GERD. Hiatal hernia prevalence (65% vs. 35%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006) and median SLR\u2010induced intra\u2010oesophageal pressure increase (14 vs. 3\u2009mmHg,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) were higher in GERD patients. Positive Milan Score was found in 65% of GERD vs. 19% of non\u2010GERD group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Milan Score values increased with higher number of positive pH days. ROC yielded AUC of 0.812 for conclusive GERD (95% CI: 0.718\u20130.895, optimal threshold 151.84, sensitivity 60.4%, specificity 92.9%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Abnormal Milan Score reliably predicts pathologic reflux per Lyon Consensus 2.0 on 96\u2010h wireless pH\u2010monitoring, with performance similar to 24\u2010h pH\u2010impedance. This validation strengthens evidence for the Milan Score in GERD diagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.70668","type":"journal-article","created":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T13:25:51Z","timestamp":1776173151000},"page":"177-185","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Validation of the Milan Score Using Prolonged Wireless PH Monitoring"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0532-3135","authenticated-orcid":false,"given":"Stefano","family":"Siboni","sequence":"first","affiliation":[{"name":"Division of General and Emergency Surgery, IRCCS Policlinico San Donato University of Milan  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiurgen","family":"Mema","sequence":"additional","affiliation":[{"name":"Division of General and Emergency Surgery, IRCCS Policlinico San Donato 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