{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T10:11:43Z","timestamp":1787825503429,"version":"build-2784847793"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Bulevirtide (BLV) blocks hepatitis D virus (HDV) entry by targeting the sodium taurocholate co\u2010transporting polypeptide (NTCP). This study assessed the relationship between bile acid (BA) levels and antiviral response to BLV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Serum BA levels were monitored in HDV\u2010infected patients pre\u2010, under, and post BLV treatment. Virologic response (VR) was defined by \u2265\u20092log\n                      <jats:sub>10<\/jats:sub>\n                      decline in HDV\u2010RNA and discriminated versus virologic non\u2010response (VNR). Delta BA levels (\u0394BA) were calculated and analysed in relation to HDV\u2010RNA dynamics. Finally, the effect of BLV treatment cessation on BA was investigated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty five patients (48% male; advanced chronic liver disease [ACLD]: 92.0%, 17 patients with VR at W48) were included. Median baseline BA levels were significantly higher in patients with ACLD and portal hypertension (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200910; 19.2 vs. 5.1\u2009\u03bcmol\/L;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015). No difference in median on\u2010treatment BA levels was detected between patients achieving VR or VNR at W24 (VR: 25.4 vs. VNR: 22.7\u2009\u03bcmol\/L;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20091.000) and W48 (VR: 25.4 vs. VNR: 20.8\u2009\u03bcmol\/L;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20091.000). Additionally, \u0394BA from baseline to W48 did not differ between VR and VNR (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.534). No significant association between \u0394BA and HDV\u2010RNA dynamics at W48 was detected. After BLV discontinuation, median BA levels significantly dropped to normal ranges (18.9\u2009\u03bcmol\/L at last on\u2010BLV assessment to 7.6\u2009\u03bcmol\/L after discontinuation;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.028). On\u2010treatment BA levels did neither associate with self\u2010reported compliance nor with treatment\u2010related adverse events.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Bulevirtide increases bile acid levels in most patients, but \u0394BA does not predict virologic response or adverse events, nor does it reflect compliance to therapy. Bile acid level monitoring during and following bulevirtide treatment is thus, not advised for clinical practise.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.70675","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T12:42:53Z","timestamp":1776775373000},"page":"196-207","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Correlation of Bile Acid Dynamics to Bulevirtide Response and Disease Severity in Patients With Hepatitis D"],"prefix":"10.1111","volume":"64","author":[{"given":"Marlene","family":"Hintersteininger","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine III Medical University of Vienna  Vienna Austria"},{"name":"Vienna Hepatic Hemodynamic Lab, Division of Gastroenterology and Hepatology, Department of Medicine III Medical University of Vienna  Vienna 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