{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T21:00:54Z","timestamp":1793912454421,"version":"4.8.0"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Upadacitinib (UPA) is effective for treating luminal Crohn's disease (CD), but data on perianal CD (pCD) remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All consecutive patients with active pCD (primary and\/or secondary lesions) treated with UPA across 13 French centres between September 2022 and August 2025 were included in a retrospective cohort study. Clinical remission was defined as absence of fistula drainage (spontaneous or on gentle pressure) and healing of anal ulcerations without initiation of new therapy. Clinical response was defined as \u2265\u200950% improvement in fistulas and\/or ulcerations based on physician assessment. Clinical outcomes were analysed using non\u2010responder imputation, and magnetic resonance imaging (MRI) outcomes as observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the 59 patients included, 43 (73%) had fistulizing pCD and 16 (27%) isolated anal ulcerations. All patients were previously exposed to at least one biologic and 79% of those with fistulizing pCD underwent prior perianal surgery. In patients with fistulizing pCD, clinical remission was achieved in 11\/43 (26%) and 11\/43 (26%) patients at 6 and 12\u2009months, respectively, clinical response in 21\/43 (49%) and 13\/43 (30%) patients. At 12\u2009months, MRI response was documented in 9\/13 (69%) and MRI remission in 1\/13 (8%) patients with fistulizing pCD. Among patients with fistulizing pCD, no factors predicted clinical remission. Among patients with isolated anal ulcerations, complete healing occurred in 5\/16 (31%) at 3\u2009months, 4\/16 (25%) at 6\u2009months and 4\/16 (25%) at 12\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this real\u2010world cohort of refractory pCD, UPA achieved clinical remission in one\u2010quarter of patients at 1\u2009year.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.70682","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T03:11:13Z","timestamp":1777345873000},"page":"235-242","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["One\u2010Year Effectiveness of Upadacitinib in Perianal Crohn's Disease: A Real\u2010World\n                    <scp>GETAID<\/scp>\n                    Study"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1294-5039","authenticated-orcid":false,"given":"Nicolas","family":"Richard","sequence":"first","affiliation":[{"name":"Department of Gastroenterology University Rouen Normandie, INSERM, ADEN UMR1073, \u201cNutrition, Inflammation and Microbiota\u2010Gut\u2010Brain Axis\u201d, CHU Rouen  Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Seksik","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology CRSA, Sorbonne Universit\u00e9, INSERM UMRS\u2010938, Gut, Liver &amp; Microbiome Research (GLIMMER) FHU, APHP, Saint\u2010Antoine Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Altwegg","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology CHU of Montpellier  Montpellier 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France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beno\u00eet","family":"Coffin","sequence":"additional","affiliation":[{"name":"Clinique Ambroise Par\u00e9 Hartman, Institut des MICI  Neuilly sur Seine France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4055-7615","authenticated-orcid":false,"given":"Anne\u2010Laure","family":"Pelletier","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology CHU Bichat\u2010Claude Bernard  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7761-2879","authenticated-orcid":false,"given":"Mathieu","family":"Uzzan","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Henri Mondor Hospital, F\u00e9d\u00e9ration Hospitalo\u2010Universitaire TRUE InnovaTive theRapy for immUne disordErs, Paris Est Cr\u00e9teil University UPEC, Assistance Publique\u2010H\u00f4pitaux de Paris 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