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The ACP was implemented in six hospitals, and two hospitals in the same region served as controls. Costs and quality of life were assessed during a baseline period (December 2020\u2013December 2021) and an intervention period after implementing the ACP (March 2022\u2013March 2023). Quality\u2010adjusted life years (QALYs) were derived from the EQ\u20105D\u20105L; disease control from the IBD\u2010Control questionnaire. A difference\u2010in\u2010differences (DiD) analysis was conducted, and the net monetary benefit and incremental cost\u2010effectiveness ratio (ICER) were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 1,173 patients were included (intervention\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009841, control\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009332). Baseline costs per patient were \u20ac23,259.96 in the intervention hospitals and \u20ac22,837.93 in the control hospitals. During the intervention period, costs decreased to \u20ac20,959.76 in intervention hospitals. This reduction was not observed in control hospitals (\u20ac22,191.21). The DiD\u2010analysis showed cost savings of \u2212\u20ac1933.69; QALYs (0.001) and disease control (0.15) did not change. The ICER indicated cost savings without compromising quality of life or disease control.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The implementation of an ACP for the treatment of patients with IBD reduces costs, maintains quality of life and disease control, and is cost\u2010effective. These results emphasise that the implementation of care pathways in current practices should be considered. Trial registration number: NL\u2010OMON21751. Website: Value\u2010based healthcare for Inflammatory Bowel Disease: Improving (cost\u2010) effectiveness.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.70690","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T11:53:39Z","timestamp":1776945219000},"page":"313-325","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Care Pathway for the Treatment of\n                    <scp>IBD<\/scp>\n                    Reduces Healthcare Costs and Is Cost\u2010Effective: Results of the Multicentre\n                    <scp>IBD<\/scp>\n                    Value Study"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6259-4954","authenticated-orcid":false,"given":"Elyke H.","family":"Visser","sequence":"first","affiliation":[{"name":"Department of Gastroenterology &amp; Hepatology Franciscus Hospital  Rotterdam the Netherlands"},{"name":"Department of Gastroenterology &amp; Hepatology Erasmus MC  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martijn. A. Oude","family":"Voshaar","sequence":"additional","affiliation":[{"name":"Department of Public Health Erasmus MC  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinier C. A.","family":"van Linschoten","sequence":"additional","affiliation":[{"name":"Department of General Practice Erasmus MC  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander G. 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