{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T06:07:42Z","timestamp":1783836462567,"version":"3.55.0"},"reference-count":54,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Entecavir and tenofovir alafenamide fumarate are potent nucleos(t)ide analogues used to treat chronic hepatitis B; however, their differential effects on hepatitis B surface antigen expression decline remain unclear. In this multicentre study, we aimed to examine the hepatitis B surface antigen\u2010reducing effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Treatment\u2010na\u00efve chronic hepatitis B patients who received entecavir (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009491) or tenofovir alafenamide fumarate (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009463) were enrolled. After 1:1 propensity score matching for sex, baseline hepatitis B surface antigen, hepatitis B e\u2010antigen status, hepatitis B virus deoxyribonucleic acid, fibrosis\u20104 score, and the presence of hepatocellular carcinoma, data from 334 patients per group were analysed. Linear mixed\u2010effects models were used to assess longitudinal changes over 4\u2009years.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Tenofovir alafenamide fumarate was associated with a greater decline in hepatitis B surface antigen compared to entecavir, with significant differences at 1, 3, and 4\u2009years. Its superiority was most pronounced in patients aged &lt;\u200965\u2009years, those without cirrhosis, those with baseline hepatitis B surface antigen \u2265\u20093.0 log IU\/mL, those with either negative or positive hepatitis B e\u2010antigen, and those with baseline hepatitis B virus deoxyribonucleic acid &lt;\u20094.4 log IU\/mL. Both treatments achieved comparable virological suppression and alanine aminotransferase normalisation. The estimated glomerular filtration rate showed a transient decline with tenofovir alafenamide fumarate in year 1, which subsequently diminished and may partly reflect the inhibition of tubular creatinine secretion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This evidence supports personalised treatment selection for functional cure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>The UMIN Clinical Trials Registry 000034362<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.70704","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:38:56Z","timestamp":1777880336000},"page":"345-355","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Superior Efficacy of Tenofovir Alafenamide Compared With Entecavir in Reducing Hepatitis B Surface Antigen: A Multicentre Propensity Score\u2010Matched Study Using Linear Mixed\u2010Effects Models"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2211-495X","authenticated-orcid":false,"given":"Takashi","family":"Kumada","sequence":"first","affiliation":[{"name":"Department of Nursing Gifu Kyoritsu University  Ogaki Japan"},{"name":"Department of Epidemiology, Infectious Disease Control, and Prevention Hiroshima University Institute of Biomedical and Health Sciences  Hiroshima 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