{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T06:07:52Z","timestamp":1783836472293,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004853","name":"Chinese University of Hong Kong","doi-asserted-by":"publisher","award":["2025.067"],"award-info":[{"award-number":["2025.067"]}],"id":[{"id":"10.13039\/501100004853","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>With the change in antidiabetic medications, the trend of glycaemic management is still unclear for type 2 diabetes mellitus (T2DM) patients, especially those with cirrhosis. We aimed to examine secular trends in glycaemic control and antidiabetic medication usage among T2DM patients with or without cirrhosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We retrospectively included T2DM adult patients with or without cirrhosis from 2000 to 2023 in Hong Kong, and excluded those with type 1 diabetes. Serial laboratory measurements in each of the five consecutive periods (2000\u20132004, 2005\u20132009, 2010\u20132014, 2015\u20132019, and 2020\u20132023) were compared by time\u2010weighted average. The percentages of patients who achieved haemoglobin A\n                      <jats:sub>1c<\/jats:sub>\n                      (HbA\n                      <jats:sub>1c<\/jats:sub>\n                      ) &lt;\u20097% and fasting blood glucose &lt;\u20097.2\u2009mmol\/L, as well as the trend of antidiabetic medication usage and hypoglycaemia incidence, were examined.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 1,206,233 patients with T2DM (mean age 63.1\u2009years, 52.0% males), 1,143,033 (94.8%), 45,208 (3.7%) and 17,992 (1.5%) had no cirrhosis, compensated and decompensated cirrhosis, respectively. All patients with or without cirrhosis had increasing proportions of patients achieving HbA\n                      <jats:sub>1c<\/jats:sub>\n                      target over the years, with compensated cirrhosis group having the best control (from 2000\u201304 to 2020\u201323: non\u2010cirrhosis group: 39.2% to 65.9%, compensated cirrhosis group: 49.3% to 75.8%, decompensated cirrhosis group: 47.6% to 64.6%). The probability of achieving glycaemic targets increased over time in all groups. Insulin was the predominant agent in decompensated cirrhosis group, with an increasing incidence of hypoglycaemia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Glycaemic control improved in T2DM patients irrespective of cirrhosis status. Further research is needed to determine the impact of sustained control on hepatic and extrahepatic outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.70705","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T08:44:52Z","timestamp":1777970692000},"page":"356-366","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Secular Trend in Glycaemic Management in Type 2 Diabetes Patients With and Without Cirrhosis Between 2000 and 2023: A Territory\u2010Wide Cohort Study"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9412-5687","authenticated-orcid":false,"given":"Mary Yue","family":"Wang","sequence":"first","affiliation":[{"name":"Medical Data Analytics Centre The Chinese University of Hong Kong  Shatin Hong Kong SAR China"},{"name":"Department of Medicine and Therapeutics The Chinese University of Hong Kong  Shatin Hong Kong SAR 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