{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T17:17:05Z","timestamp":1788801425342,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 DK120515"],"award-info":[{"award-number":["P30 DK120515"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008732","name":"Uehara Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The natural history of steatotic liver disease (SLD)\u2014including major adverse liver outcomes (MALO), major adverse cardiovascular events (MACE), and all\u2010cause mortality\u2014remains inadequately defined in population\u2010based settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We sought to quantify their incidence and compare risks across SLD subtypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We evaluated 244,760 UK Biobank participants, assessing metabolic dysfunction\u2013associated SLD (MASLD), metabolic dysfunction and alcohol\u2010associated liver disease (MetALD), or alcohol\u2010associated liver disease (ALD), and examined outcomes across these subtypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the cohort, 47,949 (19.6%) had MASLD, 23,000 (9.4%) had MetALD, and 8085 (3.3%) had ALD. Of the 79,034 individuals with SLD (mean age 57.2; 72.4% female; 98.0% White), the incidence rates of MALO (per 1,000 person\u2010years) were 1.91 for MASLD, 2.35 for MetALD, and 5.80 for ALD during a median follow\u2010up of 13.5\u2009years. Corresponding rates for MACE were 14.88, 15.48, and 19.36, and for all\u2010cause mortality were 12.99, 13.59, and 20.93. After adjustment, ALD (hazard ratio [HR], 2.95; 95% CI, 2.64\u20133.29) and MetALD (HR, 1.23; 95% CI, 1.11\u20131.36) were associated with higher MALO risk than MASLD. ALD also showed higher risks of MACE and mortality than MetALD (MACE: HR, 1.17; 95% CI, 1.10\u20131.24; mortality: HR, 1.49; 95% CI, 1.41\u20131.58) or MASLD (MACE: HR, 1.17; 95% CI, 1.11\u20131.24; mortality: HR, 1.52; 95% CI, 1.44\u20131.60), whereas MetALD and MASLD showed no differences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In the United Kingdom, ALD exhibited the highest liver, cardiovascular, and mortality risks, while MASLD and MetALD had similar cardiovascular and survival profiles but differed in liver\u2010related risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.70711","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T03:24:12Z","timestamp":1778642652000},"page":"367-378","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Subtype Differences in Major Adverse Liver Outcomes and Cardiovascular Events and Mortality in Steatotic Liver Disease: A\n                    <scp>UK<\/scp>\n                    Biobank Analysis"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6373-260X","authenticated-orcid":false,"given":"Takao","family":"Miwa","sequence":"first","affiliation":[{"name":"Department of Medicine University of California, San Diego  La Jolla California USA"},{"name":"Department of Gastroenterology\/Internal Medicine, Graduate School of Medicine Gifu University  Gifu Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8540-4930","authenticated-orcid":false,"given":"Luis Antonio","family":"D\u00edaz","sequence":"additional","affiliation":[{"name":"Department of Medicine University of California, San Diego  La Jolla California USA"},{"name":"MASLD Research Center, Division of Gastroenterology and Hepatology University of California, San Diego  La Jolla California USA"},{"name":"Departamento de Gastroenterolog\u00eda, Escuela de Medicina Pontificia Universidad Cat\u00f3lica de Chile  Santiago Santiago Metropolitan Region Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0143-8106","authenticated-orcid":false,"given":"Aenne","family":"Harberts","sequence":"additional","affiliation":[{"name":"Department of Medicine University of California, San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3378-7800","authenticated-orcid":false,"given":"Yoshimi","family":"Yukawa\u2010Muto","sequence":"additional","affiliation":[{"name":"Department of Medicine University of California, San Diego  La Jolla California 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