{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:49:36Z","timestamp":1791906576608,"version":"4.3.4"},"reference-count":51,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T00:00:00Z","timestamp":1780185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T00:00:00Z","timestamp":1780185600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The majority of the burden of metabolic dysfunction\u2010associated steatohepatitis (MASH) exists in primary care; however, the prevalence of severe disease in patients with metabolic dysfunction remains poorly described.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross\u2010sectional study of 84 general practices located in Victoria, Australia identified patients with metabolic dysfunction over a 12\u2009month period from the PATRON data repository. At\u2010risk MASH was defined using the Fibrotic NASH Index (FNI) based on laboratory data. Patients needing further liver assessment were defined by FIB\u20104\u2009\u2265\u20091.3 (\u2265\u20092.0 if 65+ years) and\u2009=\u2009&lt;\u20092.67. Advanced liver fibrosis was defined as a FIB\u20104 of &gt;\u20092.67.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      110,938 individuals were identified with metabolic dysfunction. Of those with a FNI available (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200916,586), the prevalence of At\u2010risk MASH was 24.3%. Among those with a FIB\u20104 available (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200964,948), 16.3% required further liver assessment, while the prevalence of advanced fibrosis was 4.3%. On multivariate analysis, male sex, type 2 diabetes, and hypertension were associated with At\u2010risk MASH, whereas male sex and type 2 diabetes were associated with advanced liver fibrosis. Socio\u2010economic disadvantage was a risk factor for both At\u2010risk MASH and advanced liver fibrosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Significant liver disease was observed in a substantial proportion of patients with metabolic dysfunction within primary care, particularly among patients with type 2 diabetes, supporting the rationale for risk stratification. Associations with socio\u2010economic disadvantage highlight the need for societal and public health policy change to improve liver outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.70750","type":"journal-article","created":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T15:16:03Z","timestamp":1780240563000},"page":"635-646","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Prevalence and Risk Factors for at\u2010Risk\n                    <scp>MASH<\/scp>\n                    and Advanced Liver Fibrosis in People With Metabolic Risk Factors in Primary Care"],"prefix":"10.1111","volume":"64","author":[{"given":"Leon A.","family":"Adams","sequence":"first","affiliation":[{"name":"Medical School University of Western Australia  Perth Australia"},{"name":"Department of Hepatology Sir Charles Gairdner Hospital  Perth Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoke","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of General Practice and Primary Care &amp; Collaborative Centre for Genomic Cancer Medicine The University of Melbourne  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Calzadilla\u2010Bertot","sequence":"additional","affiliation":[{"name":"Medical School University of Western Australia  Perth Australia"},{"name":"CIBER Liver and Digestive Diseases (CIBEREHD) SeLiver Group Institute of Biomedicine of Seville (IBiS)  Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silja","family":"Schrader","sequence":"additional","affiliation":[{"name":"Department of General Practice and Primary Care &amp; Collaborative Centre for Genomic Cancer Medicine The University of Melbourne  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Frear","sequence":"additional","affiliation":[{"name":"Medical School University of Western Australia  Perth Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chian","family":"Zhou","sequence":"additional","affiliation":[{"name":"Novo Nordisk  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Heywood","sequence":"additional","affiliation":[{"name":"Novo Nordisk  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon","family":"Emery","sequence":"additional","affiliation":[{"name":"Department of General Practice and Primary Care &amp; 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