{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:49:36Z","timestamp":1791906576563,"version":"4.3.4"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Overlap among disorders of gut\u2010brain interaction (DGBI) is common, with many patients experiencing concomitant non\u2010gastrointestinal symptoms. Fatigue is frequently reported, yet population\u2010based prevalence estimates across DGBI are limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To examine the prevalence and burden of fatigue among DGBI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were derived from the Rome Foundation Global Epidemiology Study's internet\u2010based survey, conducted in 26 countries using the Rome IV Adult Diagnostic Questionnaire. Fatigue was assessed with single items from the Patient\u2010Reported Outcomes Measurement Information System (PROMIS) Global\u201010 and the Patient Health Questionnaire\u201012 (PHQ\u201012). Prevalence of fatigue was compared across three groups, including no DGBI, one DGBI and multiple DGBI, with potential associated factors examined using logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 54,127 participants (49% female; mean age 44\u2009years), 59.9% had no DGBI, 26.6% had one DGBI and 13.5% had multiple DGBI. Fatigue prevalence was higher with more DGBI overlap: PROMIS 7.7% (95% CI:7.46\u20138.04), 16.4% (95% CI: 15.79\u201317.00), 30.2% (95% CI: 29.16\u201331.26); PHQ\u201012 12.6% (95% CI: 12.24\u201312.96), 25.8% (95% CI: 25.06\u201326.49), 42.0% (95% CI: 40.83\u201343.09) for no, one, and multiple DGBI. Fatigue was most common in reflux hypersensitivity (PROMIS 46%, PHQ\u201012 58%) and irritable bowel syndrome (PROMIS 39%, PHQ\u201012 53%). Among individuals with DGBI, fatigue was consistently associated across both definitions with female sex, age, BMI, sleep disturbance, higher anxiety and depression scores, greater somatic symptom burden, lower psychological well\u2010being, antidepressant use, and satiety, abdominal pain, and bloating.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Fatigue is common and burdensome in DGBI, particularly with overlapping diagnoses. Given the cross\u2010sectional design, directionality between fatigue and DGBI symptom burden remains unclear. Future research should employ longitudinal fatigue assessments to inform targeted management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.70756","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T11:30:58Z","timestamp":1779967858000},"page":"659-674","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prevalence and Burden of Fatigue Across Disorders of Gut\u2013Brain Interaction: Results From the Rome Foundation Global Epidemiology Study"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3925-3523","authenticated-orcid":false,"given":"Fleur","family":"Veldman","sequence":"first","affiliation":[{"name":"Department of Gastroenterology\u2010Hepatology NUTRIM Research Institute of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6113-8992","authenticated-orcid":false,"given":"Francesco","family":"Innocenti","sequence":"additional","affiliation":[{"name":"Department of Methodology and Statistics, Care and Public Health Research Institute (CAPHRI), Faculty of Health Medicine and Life Sciences Maastricht University  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4313-0553","authenticated-orcid":false,"given":"Imran","family":"Aziz","sequence":"additional","affiliation":[{"name":"Academic Unit of Gastroenterology Sheffield Teaching Hospitals NHS Foundation Trust  Sheffield UK"},{"name":"Division of Clinical Medicine, School of Medicine and Population Health University of Sheffield  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asma","family":"Fikree","sequence":"additional","affiliation":[{"name":"GI Physiology Unit University College London Hospital NHS Foundation Trust  London UK"},{"name":"Division of Surgery &amp; Interventional Science, Research Department of Targeted Intervention University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shrikant I.","family":"Bangdiwala","sequence":"additional","affiliation":[{"name":"Department of Health Research Methods, Evidence and Impact, Population Health Research Institute McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olafur","family":"Palsson","sequence":"additional","affiliation":[{"name":"Center for Functional GI &amp; Motility Disorders University of North Carolina\u2010Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ami D.","family":"Sperber","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences Ben\u2010Gurion University of the Negev  Be'er Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Keszthelyi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology\u2010Hepatology NUTRIM Research Institute of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,28]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.04.014"},{"issue":"4","key":"e_1_2_12_3_1","first-page":"228","article-title":"Rome Foundation Working Team Report on Overlap in Disorders of Gut\u2010Brain Interaction","volume":"22","author":"Barbara G.","year":"2025","journal-title":"Nature Reviews. 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