{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:55:55Z","timestamp":1790207755308,"version":"4.1.0"},"reference-count":150,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82573497"],"award-info":[{"award-number":["82573497"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2023ZD0502002"],"award-info":[{"award-number":["2023ZD0502002"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2025ZD0552103"],"award-info":[{"award-number":["2025ZD0552103"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Provincial Science and Technology Support Program","doi-asserted-by":"publisher","award":["2025ZNSFSC1900"],"award-info":[{"award-number":["2025ZNSFSC1900"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Provincial Science and Technology Support Program","doi-asserted-by":"publisher","award":["2025ZNSFSC1901"],"award-info":[{"award-number":["2025ZNSFSC1901"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Provincial Science and Technology Support Program","doi-asserted-by":"publisher","award":["2026NSFSC1946"],"award-info":[{"award-number":["2026NSFSC1946"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Provincial Science and Technology Support Program","doi-asserted-by":"publisher","award":["2026NSFSC1950"],"award-info":[{"award-number":["2026NSFSC1950"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019014","name":"Chengdu Municipal Science and Technology Program","doi-asserted-by":"publisher","award":["2024\u2010YF05\u201000257\u2010SN"],"award-info":[{"award-number":["2024\u2010YF05\u201000257\u2010SN"]}],"id":[{"id":"10.13039\/501100019014","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cholangiocarcinoma (CCA) is a heterogeneous group of biliary tract malignancies with increasing global incidence and poor prognosis. CCA is anatomically classified into intrahepatic (iCCA), perihilar (pCCA) and distal (dCCA) subtypes with distinct biological and clinical features. Most patients present with unresectable or metastatic disease, making systemic therapy the mainstay of treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This review summarises recent advances in systemic therapy for advanced CCA, focusing on chemotherapy, immunotherapy, targeted therapy and future therapeutic directions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive review of recent clinical studies, treatment guidelines and emerging therapeutic advances in advanced CCA was conducted. Particular emphasis was placed on first\u2010line and subsequent\u2010line systemic therapies, molecular profiling, precision oncology and novel combination treatment strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Gemcitabine\u2013cisplatin (GC) has remained the standard first\u2010line chemotherapy for advanced CCA for over a decade. Recent phase III trials demonstrated improved survival with the addition of an immune checkpoint inhibitor (ICI) to GC, establishing chemoimmunotherapy as the current standard first\u2010line treatment. Approximately 40%\u201350% of patients harbour actionable genomic alterations, including fibroblast growth factor receptor (FGFR) fusions and isocitrate dehydrogenase (IDH) mutations. Targeted therapies against these alterations have shown meaningful clinical benefit and received US Food and Drug Administration (FDA) approval as second\u2010line treatments. However, therapeutic resistance and molecular heterogeneity remain major challenges.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Systemic treatment for advanced CCA is rapidly evolving toward biomarker\u2010driven and immunotherapy\u2010based strategies. Integration of molecular profiling and precision oncology may further improve individualised treatment and clinical outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.70769","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T12:48:42Z","timestamp":1780490922000},"page":"148-165","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Review Article: Systemic Treatments for Advanced Cholangiocarcinoma\u2014State of the Art and Future Directions"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8899-4836","authenticated-orcid":false,"given":"Weili","family":"Qi","sequence":"first","affiliation":[{"name":"Department of General Surgery West China Hospital, Sichuan University  Chengdu China"},{"name":"Liver Transplant Center, Transplant Center West China Hospital, Sichuan University  Chengdu China"},{"name":"Laboratory of Hepatic AI Translation, Frontiers Science Center for Disease\u2010Related Molecular Network West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojuan","family":"Yang","sequence":"additional","affiliation":[{"name":"Laboratory of Hepatic AI Translation, Frontiers Science Center for Disease\u2010Related Molecular Network West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghao","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of General Surgery West China Hospital, Sichuan University  Chengdu China"},{"name":"Liver Transplant Center, Transplant Center West China Hospital, Sichuan University  Chengdu China"},{"name":"Laboratory of Hepatic AI Translation, Frontiers Science Center for Disease\u2010Related Molecular Network West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of General Surgery West China Hospital, Sichuan University  Chengdu China"},{"name":"Liver Transplant Center, Transplant Center West China Hospital, Sichuan University  Chengdu China"},{"name":"Laboratory of Hepatic AI Translation, Frontiers Science Center for Disease\u2010Related Molecular Network West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,3]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21820"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-020-0310-z"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.10.013"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2017.157"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2021.11.023"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00153-7"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2022.07.022"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14095"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2016.51"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00300-2"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073274817729241"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2021.1864325"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231810869"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms262411961"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.annonc.a010676"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29471"},{"key":"e_1_2_13_18_1","first-page":"2020","article-title":"Prospective Randomized Trial of 5\u2010Fluorouracil, Doxorubicin, and Mitomycin C for Non\u2010Resectable Pancreatic and Biliary Carcinoma: Multicenter Randomized Trial","volume":"45","author":"Takada T.","year":"1998","journal-title":"Hepato\u2010Gastroenterology"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605211"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0908721"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2025.0042"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2022.10.506"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2023-330029"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhbp.1219"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz402"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz058"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(21)00027-9"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-018-0138-2"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2023.0016"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.4322\/acr.2019.087"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3375"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-18-0078"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2022.09.004"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-20-0766"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1200\/PO.18.00324"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-17-0245"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31829"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.21037\/tgh.2018.07.02"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-022-01908-1"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2021.12.006"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.21037\/jgo.2019.03.10"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2020.08.006"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-016-9645-x"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.03.008"},{"key":"e_1_2_13_45_1","first-page":"55","article-title":"Targeted Therapies in Cholangiocarcinoma: Emerging Evidence From Clinical Trials","volume":"55","author":"Simile M. M.","year":"2019","journal-title":"Medicina (Kaunas, Lithuania)"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.03.007"},{"key":"e_1_2_13_47_1","article-title":"Analysis of NTRK Alterations in Pan\u2010Cancer Adult and Pediatric Malignancies: Implications for NTRK\u2010Targeted Therapeutics","volume":"2018","author":"Okamura R.","year":"2018","journal-title":"JCO Precision Oncology"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-1679"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.21037\/hbsn.2019.08.05"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan6733"},{"key":"e_1_2_13_51_1","first-page":"13","article-title":"Targeted Therapies in Advanced Cholangiocarcinoma","volume":"13","author":"Storandt M. H.","year":"2023","journal-title":"Life (Basel)"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19051421"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-018-0115-y"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-020-06804-6"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2021.100378"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-17-0368"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.75.5009"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-16-1000"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-19-0182"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30109-1"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2024.103488"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(21)00196-5"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-020-01330-y"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-021-01567-1"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1080\/13543784.2021.1864320"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-020-01157-0"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1093\/oncolo\/oyad149"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2206834"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-022-01806-z"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2023.102049"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-23-0475"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-23-3588"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-21-1168"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.10.041"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08617"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-20-1827"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-21-4462"},{"key":"e_1_2_13_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30157-1"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41698-022-00304-5"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2022.215603"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-25-0174"},{"key":"e_1_2_13_82_1","doi-asserted-by":"publisher","DOI":"10.2174\/0118715206382095250908095950"},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2304194"},{"key":"e_1_2_13_84_1","article-title":"HMPL\u2010306 in Relapsed or Refractory IDH1\u2010 and\/or IDH2\u2010Mutated Acute Myeloid Leukemia: A Phase 1 Study","volume":"6","author":"Hu L.","year":"2025","journal-title":"Medicus"},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2023.115411"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.1093\/oncolo\/oyae163"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41421-023-00523-5"},{"key":"e_1_2_13_88_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15092628"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-36399-y"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(23)00242-5"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-025-02163-3"},{"key":"e_1_2_13_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(21)00336-3"},{"key":"e_1_2_13_93_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.02010"},{"key":"e_1_2_13_94_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.02005"},{"key":"e_1_2_13_95_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-24-0306"},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.860339"},{"key":"e_1_2_13_97_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.01193"},{"key":"e_1_2_13_98_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.1476"},{"key":"e_1_2_13_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(21)00171-0"},{"key":"e_1_2_13_100_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1502309"},{"key":"e_1_2_13_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30321-1"},{"key":"e_1_2_13_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-023-00852-0"},{"key":"e_1_2_13_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2018.08.019"},{"key":"e_1_2_13_104_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-21-1331"},{"key":"e_1_2_13_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2016.139"},{"key":"e_1_2_13_106_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.00434"},{"key":"e_1_2_13_107_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.71260"},{"key":"e_1_2_13_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.216904"},{"key":"e_1_2_13_109_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-022-01629-2"},{"key":"e_1_2_13_110_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1554356"},{"key":"e_1_2_13_111_1","first-page":"1229","article-title":"Positive Feedback Between Oncogenic KRAS and HIF\u20101\u03b1 Confers Drug Resistance in Colorectal Cancer","volume":"8","author":"Wang Y.","year":"2015","journal-title":"OncoTargets and Therapy"},{"key":"e_1_2_13_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-018-0113-0"},{"key":"e_1_2_13_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2019.101911"},{"key":"e_1_2_13_114_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-018-1044-x"},{"key":"e_1_2_13_115_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-20-2771"},{"key":"e_1_2_13_116_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1714448"},{"key":"e_1_2_13_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30691-6"},{"key":"e_1_2_13_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2020.09.020"},{"key":"e_1_2_13_119_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-18-0484"},{"key":"e_1_2_13_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2023.09.2405"},{"key":"e_1_2_13_121_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO-25-00275"},{"key":"e_1_2_13_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(22)00541-1"},{"key":"e_1_2_13_123_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-23-0459"},{"key":"e_1_2_13_124_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01931-y"},{"key":"e_1_2_13_125_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31872"},{"key":"e_1_2_13_126_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.32964"},{"key":"e_1_2_13_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.05.018"},{"key":"e_1_2_13_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2021.11.012"},{"key":"e_1_2_13_129_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12094\u2010025\u201004202\u20107"},{"key":"e_1_2_13_130_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.02105"},{"key":"e_1_2_13_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2022.05.519"},{"key":"e_1_2_13_132_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-18-4070"},{"key":"e_1_2_13_133_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.41165"},{"key":"e_1_2_13_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)00727-4"},{"key":"e_1_2_13_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(24)00095-5"},{"key":"e_1_2_13_136_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-025-02356-y"},{"key":"e_1_2_13_137_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2020-001240"},{"key":"e_1_2_13_138_1","doi-asserted-by":"publisher","DOI":"10.1002\/cti2.1483"},{"key":"e_1_2_13_139_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2020.2814"},{"key":"e_1_2_13_140_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-60119-3"},{"key":"e_1_2_13_141_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI152670"},{"key":"e_1_2_13_142_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2018-0044"},{"key":"e_1_2_13_143_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-71746-z"},{"key":"e_1_2_13_144_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21287"},{"key":"e_1_2_13_145_1","doi-asserted-by":"publisher","DOI":"10.1053\/lv.2000.6143"},{"key":"e_1_2_13_146_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000003801"},{"key":"e_1_2_13_147_1","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000001129"},{"key":"e_1_2_13_148_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.04.008"},{"key":"e_1_2_13_149_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32258"},{"key":"e_1_2_13_150_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature21349"},{"key":"e_1_2_13_151_1","doi-asserted-by":"publisher","DOI":"10.1080\/02656736.2020.1763484"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.70769","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apt.70769","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.70769","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T21:37:48Z","timestamp":1782509868000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.70769"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,3]]},"references-count":150,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/apt.70769"],"URL":"https:\/\/doi.org\/10.1111\/apt.70769","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,3]]},"assertion":[{"value":"2026-03-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}