{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:45:19Z","timestamp":1791830719948,"version":"4.3.4"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["10140022010008"],"award-info":[{"award-number":["10140022010008"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023453","name":"Norgine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Iron deficiency anaemia (IDA) is common in inflammatory bowel disease (IBD) and impairs quality of life. Hepcidin, the regulator of systemic iron homeostasis, may predict response to iron therapy; however, its utility in IBD remains unclear. This study evaluated whether baseline hepcidin predicts response to oral and intravenous (IV) iron in active IBD to guide personalised treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Ninety adults with active IBD and iron deficiency (with or without anaemia) from two randomised trials received IV iron, oral ferrous fumarate (FF) or oral ferric maltol (FM). Response at 12\u2009weeks was defined as haemoglobin increase \u2265\u20091.2\u2009mmol\/L (19.3\u2009g\/L) or normalisation in IDA or ferritin &gt;\u2009100\u2009\u03bcg\/L and transferrin saturation &gt;\u200920% in iron deficient patients. Baseline iron indices including ferritin, hepcidin, and soluble transferrin receptor (sTfR) were measured. Logistic regression and receiver operating curve analyses evaluated predictive performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Baseline hepcidin strongly predicted response to iron therapy: AUC\n                      <jats:sub>(FF)<\/jats:sub>\n                      : 0.86, 95% CI: 0.71\u20131.00 and AUC\n                      <jats:sub>(IV)<\/jats:sub>\n                      : 0.63, 95% CI: 0.30\u20130.96. Hepcidin &gt;\u20092.68\u2009\u03bcg\/mL identified non\u2010responders to FF with 89% sensitivity and 77% specificity. Each twofold increase in baseline hepcidin or ferritin reduced the odds of response [log\n                      <jats:sub>2<\/jats:sub>\n                      (hepcidin) OR: 0.71, 95% CI: 0.56\u20130.89; log\n                      <jats:sub>2<\/jats:sub>\n                      (ferritin) OR: 0.38, 95% CI: 0.21\u20130.69]. Higher transferrin\/log\n                      <jats:sub>10<\/jats:sub>\n                      (ferritin) (OR: 2.95, 95% CI: 1.38\u20136.30) and sTfR\/log\n                      <jats:sub>10<\/jats:sub>\n                      (ferritin) ratios (OR: 1.29, 95% CI: 1.05\u20131.59) increased likelihood of response.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Baseline hepcidin supports route selection for iron therapy: higher levels favour IV iron, while lower levels indicate likely oral response. Ferritin\u2010based indices, notably transferrin\/log\n                      <jats:sub>10<\/jats:sub>\n                      (ferritin), offer pragmatic alternatives where hepcidin testing is unavailable.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      identifier: NCT05581420 and NCT05456932\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.70775","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T06:37:31Z","timestamp":1780987051000},"page":"166-176","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical Trial: Predicting Response to Iron Therapy in Patients With Active Inflammatory Bowel Disease Using Hepcidin and Functional Iron Indices: A Multicentre Randomised Trial"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0357-2146","authenticated-orcid":false,"given":"Lola J. M.","family":"Koppelman","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Loveikyte","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rogier L.","family":"Goetgebuer","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Amsterdam University Medical Center  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7672-2483","authenticated-orcid":false,"given":"Sander","family":"van der Marel","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Haaglanden Medical Center  Den Haag the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3988-9201","authenticated-orcid":false,"given":"Annemarie C.","family":"de Vries","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Erasmus University Medical Center  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Dijkstra","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology University Medical Center Groningen, University of Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9353-5431","authenticated-orcid":false,"given":"Andrea E.","family":"van der Meulen\u2010de Jong","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Dutch Iron Study 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