{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:55:39Z","timestamp":1790618139689,"version":"4.1.0"},"reference-count":59,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Inflammatory bowel disease (IBD) and myeloproliferative neoplasms (MPNs) share chronic inflammation and immune dysregulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>We evaluated the incidence of MPNs among patients with IBD and clinical outcomes of IBD\u2013MPN coexistence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Two retrospective cohort analyses were conducted using the TriNetX database. First, adults with ulcerative colitis (UC) or Crohn's disease (CD) were compared with matched non\u2010IBD controls to estimate incident MPN risk. A coexistence second analysis included patients with UC or CD who developed MPNs and then were matched to IBD without MPN controls to assess 5\u2010year outcomes, including IBD\u2010related complications, surgical interventions, colorectal cancer (CRC) and primary sclerosing cholangitis (PSC). Medication subgroup analyses were performed to evaluate associations with MPN risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After matching, 3873 patients with UC\u2013MPN and 3474 patients with CD\u2013MPN were included. Compared with matched non\u2010IBD controls, incident MPN risk was higher in UC (HR 1.60,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01) and CD (HR 1.56,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). In CD, MPN coexistence was associated with higher risks of CRC (HR 1.52,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012), intestinal fistula (HR 2.84,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), obstruction (HR 2.05,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), perforation (HR 2.37,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), small bowel resection (HR 3.69,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and colectomy (HR 2.10,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). In UC, MPN coexistence was associated with higher risks of CRC (HR 1.50,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001), PSC (HR 1.75,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03) and pouchitis (HR 1.68,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003). Exposure to thiopurines (HR 1.28,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) was associated with increased MPN risk, whereas TNF, IL\u201023 and JAK inhibitors were not.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>IBD is associated with increased MPN risk, and IBD\u2013MPNs coexistence is associated with worse IBD\u2010related complications and malignancy risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.70779","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T07:14:41Z","timestamp":1783062881000},"page":"770-780","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Risk of Myeloproliferative Neoplasms in Patients With Inflammatory Bowel Disease and Impact on Outcomes: A Multi\u2010Centre Matched Analysis"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6662-5883","authenticated-orcid":false,"given":"Mohamed H.","family":"Eldesouki","sequence":"first","affiliation":[{"name":"Department of Internal Medicine New York Medical College at Saint Michael's Medical Center  Newark New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0641-1278","authenticated-orcid":false,"given":"Ahmed","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology &amp; Hepatology Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammed M.","family":"Marey","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine Alexandria University  Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadi F.","family":"Francis","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology &amp; Hepatology Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saqr","family":"Alsakarneh","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology &amp; Hepatology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto","family":"Ayala","sequence":"additional","affiliation":[{"name":"Division of Haematology and Oncology Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aasma","family":"Shaukat","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology NYU Grossman School of Medicine, NYU Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis A.","family":"Farraye","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology &amp; Hepatology Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana G.","family":"Hashash","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology &amp; Hepatology Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj\u20102025\u2010079050"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000003542"},{"key":"e_1_2_9_4_1","article-title":"Extraintestinal Manifestations in Inflammatory Bowel Disease: From Pathophysiology to Treatment","volume":"12","author":"Faggiani 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