{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:22:18Z","timestamp":1790889738821,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Risankizumab, a selective interleukin\u201023 p19 inhibitor, has demonstrated efficacy in clinical trials for moderate\u2010to\u2010severe Crohn's disease, but real\u2010world data in highly refractory populations are limited. We evaluated the short\u2010term effectiveness and outcomes at last follow\u2010up of risankizumab and the impact of prior advanced therapy exposure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicentre observational study included adult patients with predominantly refractory Crohn's disease treated with risankizumab and registered in the ENEIDA registry. Steroid\u2010free clinical remission, defined as a Harvey\u2013Bradshaw Index \u2264\u20094 without systemic corticosteroids, was assessed at weeks 8\u201312 and at the last available follow\u2010up visit. Multivariable logistic regression was used to identify factors associated with remission at last follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 857 patients with predominantly refractory Crohn's disease were included. Steroid\u2010free clinical remission was achieved in 56% of patients at weeks 8\u201312 and in 61% at last follow\u2010up (mean follow\u2010up: 7.4\u2009months). Remission rates were higher in patients previously exposed to \u2264\u20092 biologic therapies than in those exposed to &gt;\u20092 biologic therapies at both time points (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Prior ustekinumab exposure was associated with lower remission rates in unadjusted analyses but was not independently associated with remission at last follow\u2010up. Treatment\u2010related adverse events occurred in 8% of patients, with no serious adverse events.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this large real\u2010world cohort of patients with refractory Crohn's disease, risankizumab achieved clinically meaningful steroid\u2010free clinical remission, both at early assessment and at last follow\u2010up, with effectiveness primarily influenced by cumulative biologic exposure and demonstrating a favourable safety profile.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.70783","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T11:00:51Z","timestamp":1781089251000},"page":"781-791","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Real\u2010World Effectiveness of Risankizumab in Refractory Crohn's Disease: The RISANCROHN Study From the ENEIDA Registry"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5915-1477","authenticated-orcid":false,"given":"Manuel","family":"Barreiro\u2010de Acosta","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Complexo Hospitalario Universitario de Santiago and Fundaci\u00f3n Instituto de Investigaci\u00f3n Sanitaria de Santiago de Compostela (FIDIS)  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamile","family":"Zabana","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Universitari M\u00fatuaTerrassa, Terrassa, Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd)  Terrassa Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Nieto\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Complexo Hospitalario Universitario de Santiago and Fundaci\u00f3n Instituto de Investigaci\u00f3n Sanitaria de Santiago de Compostela (FIDIS)  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Poncela","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Instituto de Investigaci\u00f3n Biom\u00e9dica Gregorio Mara\u00f1\u00f3n (IiSGM)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariam","family":"Aguas","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Universitari i Polit\u00e8cnic La Fe, Instituto de Investigaci\u00f3n Sanitaria La Fe  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Mart\u00ednez\u2010Cuevas","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Universitario R\u00edo Hortega  Valladolid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Arg\u00fcelles\u2010Arias","sequence":"additional","affiliation":[{"name":"Universidad de Sevilla. Facultad de Medicina. Department of Gastroenterology Hospital Universitario Virgen Macarena  Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Calvo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Universitario Puerta de Hierro Majadahonda  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla J.","family":"Gargallo\u2010Puyuelo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Cl\u00ednico Universitario Lozano Blesa, IIS Arag\u00f3n and CIBERehd  Zaragoza Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7235-6864","authenticated-orcid":false,"given":"Luc\u00eda","family":"Zabalza","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Universitario de Navarra  Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar Varela","family":"Trastoy","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital de Cabue\u00f1es  Gij\u00f3n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maia M.","family":"Bosc\u00e1\u2010Watts","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Cl\u00ednico Universitario de Valencia, Universitat de Val\u00e8ncia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Ceballos","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Universitario de Gran Canaria Dr. Negr\u00edn. Departamento de Ciencias M\u00e9dicas y Quir\u00fargicas. Universidad de Las Palmas  Las Palmas Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina Mart\u00ednez","family":"Pascual","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Cl\u00ednico Universitario Virgen de la Arrixaca  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Rodr\u00edguez\u2010Moranta","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Universitario de Bellvitge, IDIBELL, L'Hospitalet de Llobregat  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Luisa","family":"de Castro Parga","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital \u00c1lvaro Cunqueiro, Grupo de Investigaci\u00f3n en Patolog\u00eda Digestiva, Instituto de Investigaci\u00f3n Sanitaria Galicia Sur (IIS)  Vigo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Su\u00e1rez","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Complejo Asistencial Universitario de Le\u00f3n  Le\u00f3n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blau","family":"Camps","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital del Mar, IMIM  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanesa","family":"Royo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Son Espases  Palma de Mallorca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iria","family":"Baston\u2010Rey","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Complexo Hospitalario Universitario de Santiago and Fundaci\u00f3n Instituto de Investigaci\u00f3n Sanitaria de Santiago de Compostela (FIDIS)  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"de Francisco","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Universitario Central de Asturias  Oviedo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Garc\u00eda\u2010Lopez","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Universitario Miguel Servet  Zaragoza Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1872-0917","authenticated-orcid":false,"given":"Mar\u00eda Dolores","family":"Mart\u00edn\u2010Arranz","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Universitario La Paz  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Bermejo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Universitario de Fuenlabrada  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inmaculada","family":"Alonso\u2010Abreu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Universitario de Canarias  Santa Cruz de Tenerife Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2090-3445","authenticated-orcid":false,"given":"Javier P.","family":"Gisbert","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS\u2010Princesa), Universidad Aut\u00f3noma de Madrid (UAM), Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Rivero","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Universitario Marqu\u00e9s de Valdecilla, IDIVAL  Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Sicilia","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Universitario de Burgos  Burgos Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Nicol\u00e1s","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital General Universitario Reina Sof\u00eda  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Teller","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Althaia Xarxa Assistencial Universit\u00e0ria de Manresa  Manresa Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngel Ponferrada","family":"D\u00edaz","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Universitario Infanta Leonor  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3354-1594","authenticated-orcid":false,"given":"Elena","family":"Ricart","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Cl\u00ednic i Provincial, IDIBAPS  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Algara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Universitario 12 de Octubre  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Fradejas","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Complejo Asistencial de Zamora  Zamora Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Robledo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Universitario de C\u00e1ceres  C\u00e1ceres 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de Elche  Alicante Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Ses\u00e9","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Universitario Arnau de Vilanova  Lleida Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8653-207X","authenticated-orcid":false,"given":"Alejandro","family":"Hernandez\u2010Camba","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Universitario Nuestra Se\u00f1ora de Candelaria, Santa Cruz de Tenerife, Spain. Instituto de Investigaci\u00f3n Sanitaria de Canarias (IISC)  Santa Cruz de Tenerife Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Izquierdo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Cl\u00ednico Universitario R\u00edo Valladolid  Valladolid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana M.","family":"Trapero","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital de Ja\u00e9n  Ja\u00e9n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Iglesias","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Reina Sof\u00eda  C\u00f3rdoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Teresa","family":"Diz\u2010Lois Palomares","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Universitario a Coru\u00f1a  Coru\u00f1a Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8661-0608","authenticated-orcid":false,"given":"Eduard","family":"Brunet\u2010Mas","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Parc Taul\u00ed Hospital Universitari. Institut d'Investigaci\u00f3 i Innovaci\u00f3 Parc Taul\u00ed (I3PT\u2010CERCA). Sabadell Catalunya, Departament de Medicina, Universitat Aut\u00f2noma de Barcelona y Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD), and Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Castro Poceiro","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital de Sant Joan Desp\u00ed Mois\u00e8s Broggi  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Busquets","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Dr. Josep Trueta  Girona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Manosa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hospital Universitari Germans Trias i Pujol Badalona, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD), and Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram\u00f3n","family":"Pajares","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Universitario Infanta Sof\u00eda  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan A.","family":"Ferrer","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Universitario Fundaci\u00f3n Alcorc\u00f3n  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Carpio","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Universitario de Pontevedra  Pontevedra 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Palencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Mart\u00ednez","family":"Flores","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital General La Mancha Centro  Ciudad Real Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Gonz\u00e1lez\u2010Mu\u00f1oza","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital de la Santa Creu i Sant Pau  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Mart\u00edn","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Universitario Infanta Cristina, Parla  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Menacho","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Joan XXIII  Tarragona 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Trias i Pujol Badalona, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD), and Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roc\u00edo","family":"Ferreiro\u2010Iglesias","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Complexo Hospitalario Universitario de Santiago and Fundaci\u00f3n Instituto de Investigaci\u00f3n Sanitaria de Santiago de Compostela (FIDIS)  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"ENEIDA Project of GETECCU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31711-1"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14852"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.233"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)00467-6"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)00466-4"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjae164"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.17358"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2024.04.016"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjaf070"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izad315"},{"key":"e_1_2_11_12_1","article-title":"Real\u2010World 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