{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:19:34Z","timestamp":1790144374558,"version":"4.0.1"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Real\u2010world evidence is needed to understand the comparative effectiveness of biologics in Crohn's disease (CD) under routine\u2010care conditions. We conducted a pooled analysis of individual patient data from prospective German CD registries (BioCrohn, RUN\u2010CD, VEDO\u2010IBD) in the UMBRELLA\u2010IBD data warehouse.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included 1567 adults with CD who initiated anti\u2010TNF therapy (adalimumab or infliximab), ustekinumab or vedolizumab. The main outcome was clinical remission (CR) at 24\u2009months (HBI \u2264\u20094). Additional outcomes included HBI, EQ\u2010VAS and treatment persistence over time. Between\u2010group comparisons used propensity\u2010score\u2010based inverse probability of treatment weighting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After weighting, CR following induction was observed in a slightly higher proportion of patients initiating anti\u2010TNF therapy (74.5%) than ustekinumab (69.4%) or vedolizumab (65.3%) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.035). Clinical response was 77.9%, 73.5% and 67.8%, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015). At 24\u2009months, CR rates were similar in magnitude (anti\u2010TNF, 53.4%; ustekinumab, 63.5%; vedolizumab, 58.7%) but were higher with ustekinumab than anti\u2010TNF (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004). Over 24\u2009months, treatment persistence differed (log\u2010rank\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and was highest for adalimumab (81.4%), lowest for infliximab (66.6%), and intermediate for ustekinumab (78.6%) and vedolizumab (76.9%). HBI decreased and remained low, and EQ\u2010VAS improved, with no relevant between\u2010group differences.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Overall effectiveness in CD was high, with only small differences between biologic therapies. At the end of induction, CR was slightly higher with anti\u2010TNF therapy than with vedolizumab, whereas at 24\u2009months it was slightly higher with ustekinumab than with anti\u2010TNF. Marked differences in treatment persistence among the evaluated biologics suggest that persistence as an endpoint is not fully explained by CR alone.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.70796","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T03:35:21Z","timestamp":1781580921000},"page":"815-827","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparative Real\u2010World Effectiveness of Anti\u2010\n                    <scp>TNF<\/scp>\n                    , Ustekinumab and Vedolizumab in Crohn's Disease Over 24\u2009Months: A Pooled Analysis From the Prospective\n                    <scp>UMBRELLA<\/scp>\n                    \u2010\n                    <scp>IBD<\/scp>\n                    Registry in Germany"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4238-751X","authenticated-orcid":false,"given":"Arne","family":"Bokemeyer","sequence":"first","affiliation":[{"name":"Department for Gastroenterology Diabetology and Palliative Care, Bonifatius Hospital Lingen  Lingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3735-9872","authenticated-orcid":false,"given":"Florian","family":"Tran","sequence":"additional","affiliation":[{"name":"Clinic of General Internal Medicine I, University Hospital Schleswig\u2010Holstein  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1945-4198","authenticated-orcid":false,"given":"Sandra","family":"Plachta\u2010Danielzik","sequence":"additional","affiliation":[{"name":"Competence Network IBD  Kiel Germany"},{"name":"Institute of Human Nutrition and Food Science, Kiel University  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6079-0240","authenticated-orcid":false,"given":"Elena","family":"Gilman","sequence":"additional","affiliation":[{"name":"Competence Network IBD  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0491-5670","authenticated-orcid":false,"given":"Thomas","family":"Wenske","sequence":"additional","affiliation":[{"name":"Competence Network IBD  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6436-2703","authenticated-orcid":false,"given":"Matthew","family":"Gaskins","sequence":"additional","affiliation":[{"name":"Independent Public Health Researcher  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6807-9822","authenticated-orcid":false,"given":"Stefan","family":"Schreiber","sequence":"additional","affiliation":[{"name":"Clinic of General Internal Medicine I, University Hospital Schleswig\u2010Holstein  Kiel Germany"},{"name":"Competence Network IBD  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2016-6991","authenticated-orcid":false,"given":"Bernd","family":"Bokemeyer","sequence":"additional","affiliation":[{"name":"Clinic of General Internal Medicine I, University Hospital Schleswig\u2010Holstein  Kiel Germany"},{"name":"Competence Network IBD  Kiel Germany"},{"name":"Interdisciplinary Crohn Colitis Centre Minden  Minden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.3238\/arztebl.2009.0123"},{"issue":"5","key":"e_1_2_14_3_1","first-page":"300","article-title":"Measuring Disability in IBD: The IBD Disability Index","volume":"9","author":"Colombel J. 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