{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T03:02:49Z","timestamp":1791514969028,"version":"4.3.4"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2026,8]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Despite increasingly refined diagnostic strategies and regularly updated treatment guidelines, real\u2010world outcomes of\n \n Helicobacter pylori<\/jats:italic>\n <\/jats:styled-content>\n management remain variable. Antimicrobial resistance alone does not fully explain these discrepancies, suggesting important challenges in the implementation of evidence\u2010based care.\n <\/jats:p>\n <\/jats:sec>\n \n Aims<\/jats:title>\n \n To identify recurring implementation\u2010related challenges across the\n \n Helicobacter pylori<\/jats:italic>\n <\/jats:styled-content>\n care pathway and highlight priorities for improving real\u2010world management.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This expert\u2010informed review integrated relevant literature, international guideline documents, and structured international expert prioritisation. An initial list of implementation\u2010related pitfalls was developed through literature review, clinical experience, and discussions among the coordinating authors and selected co\u2010authors. Twenty\u2010six experts from five continents participated in a structured consultation process and rated predefined pitfalls using a 5\u2010point Likert scale. Median scores were used for relative prioritisation.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Treatment selection and patient management emerged as the domains most consistently prioritised by participating experts. High\u2010impact pitfalls included empirical triple therapy in high\u2010resistance settings, inadequate patient counselling, and empirical retreatment without escalation. Additional challenges were identified across diagnostic, treatment, and follow\u2010up domains, highlighting persistent implementation\u2010related barriers throughout the care pathway.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Recurring implementation\u2010related challenges remain important barriers to optimal\n \n Helicobacter pylori<\/jats:italic>\n <\/jats:styled-content>\n management. Structured expert prioritisation highlights potential targets for improvement and supports further research and implementation\u2010focused strategies to improve delivery of care.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/apt.70798","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T03:06:03Z","timestamp":1781751963000},"page":"308-312","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Review Article: Implementation Challenges in\n Helicobacter pylori<\/i>\n Management: Bridging Evidence and Real\u2010World Practice"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0141-921X","authenticated-orcid":false,"given":"Duc Trong","family":"Quach","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Gastro\u2010Hepato Integrated Research Team (GHIRT\u2010002.TCM2025) University of Medicine and Pharmacy at Ho Chi Minh City Ho Chi Minh City Vietnam"},{"name":"Department of Gastroenterology Nhan Dan Gia Dinh Hospital Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7945-5408","authenticated-orcid":false,"given":"Jyh\u2010Ming","family":"Liou","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine and Medical Research, National Taiwan University Hospital National Taiwan University College of Medicine Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2090-3445","authenticated-orcid":false,"given":"Javier P.","family":"Gisbert","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS\u2010Princesa) Universidad Aut\u00f3noma de Madrid (UAM), and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5993-1059","authenticated-orcid":false,"given":"Wai Keung","family":"Leung","sequence":"additional","affiliation":[{"name":"Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine University of Hong Kong Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3447-0388","authenticated-orcid":false,"given":"Steven F.","family":"Moss","sequence":"additional","affiliation":[{"name":"Brown University Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1686-5047","authenticated-orcid":false,"given":"Carlo A.","family":"Fallone","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology McGill University Health Center Montreal 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