{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:32:35Z","timestamp":1790872355630,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["32003B_204751\/1"],"award-info":[{"award-number":["32003B_204751\/1"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Both eosinophilic oesophagitis (EoE) and chronic rhinosinusitis (CRS) are type 2 inflammatory conditions sharing pathogenic mechanisms, therapeutic responses and atopic associations. Data on the prevalence of CRS in EoE patients is missing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Our aim was to assess the prevalence of CRS\u2010type symptoms in EoE patients, the quality of life and shared characteristics of patients with both diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We assessed the point prevalence of CRS in Swiss Eosinophilic Esophagitis Cohort Study patients using a validated screening questionnaire comprising four symptom\u2010based diagnostic criteria. CRS was defined based on symptoms only (definition A) and including self\u2010reported CRS diagnosis by a physician (definition B). Point prevalence was tested against population prevalence using two\u2010sided binomial tests. Secondary outcomes were compared between patients with and without CRS. Multivariable logistic regression models were built to adjust for confounders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      211 patients (54%) answered our questionnaire. Prevalence of CRS\u2010type symptoms was 21.8% (definition A) or 25.1% (definition B), compared to 8.71% in the general population (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). CRS status was associated with increased EoE symptom severity. This association persisted after adjustment in multivariable logistic models, most consistently under definition A. 25% reported that their CRS symptoms were more debilitating than their EoE symptoms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CRS\u2010type symptoms are two\u2010 to three times more prevalent in EoE patients than in the general population and substantially impact quality of life. Our findings indicate that CRS may be under\u2010diagnosed in EoE and support routine CRS screening in EoE patients and cross\u2010speciality collaboration, particularly as both conditions benefit from therapeutic strategies targeting type 2 inflammation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.70819","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T03:38:24Z","timestamp":1782445104000},"page":"965-975","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Eosinophilic Oesophagitis Beyond the Oesophagus: High Prevalence of Chronic Rhinosinusitis\u2010Type Symptoms and Their Impact on Symptom Severity in Swiss\n                    <scp>EoE<\/scp>\n                    Cohort Study Patients"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8147-9659","authenticated-orcid":false,"given":"Gebhardt","family":"Aidan","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology University Hospital Zurich  Zurich Switzerland"},{"name":"Department of Internal Medicine Cantonal Hospital Frauenfeld  Frauenfeld Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kreienb\u00fchl","family":"Andrea","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology University Hospital Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greuter","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology University Hospital Zurich  Zurich Switzerland"},{"name":"Department of Gastroenterology and Hepatology Spital Wetzikon  Wetzikon Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Schlag","family":"Christoph","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology University Hospital Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nennstiel","family":"Simon","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology University Hospital Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saner","family":"Catherine","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossel","family":"Jean\u2010Benoit","sequence":"additional","affiliation":[{"name":"Department of Clinical Research University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauthe","family":"Tina","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery University Hospital Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8674-1007","authenticated-orcid":false,"given":"M.","family":"Meerwein Christian","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery University Hospital Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Schoepfer","family":"Alain","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Soyka Michael","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery University Hospital Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Straumann","family":"Alex","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology University Hospital Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biedermann","family":"Luc","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology University Hospital Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Swiss EoE Cohort Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281\u2010021\u201000855\u2010y"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2024.09.031"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.09.013"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12733"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13441"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ueg2.12092"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/dote\/doy015"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/181402"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2014.09.022"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2022.01.016"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.14592"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin20.600"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.06.726"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.1287"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102023\u2010330337"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15772"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2313318"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.12.347"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/19458924221116162"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000486131"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000531060"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin12.029"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398\u20109995.2010.02503.x"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2010.04.012"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599818811328"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.4103\/sja.SJA_543_18"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v111.i09"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin20.601"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin21.446"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2005.01.028"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.3978\/j.issn.2224\u20105820.2015.09.04"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000001642"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/01455613241286611"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001950"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15982"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2019.03.023"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(19)31881\u20101"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/falgy.2024.1427279"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/falgy.2025.1543504"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.70819","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apt.70819","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.70819","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T02:28:09Z","timestamp":1789180089000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.70819"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,25]]},"references-count":39,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/apt.70819"],"URL":"https:\/\/doi.org\/10.1111\/apt.70819","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,25]]},"assertion":[{"value":"2026-05-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}