{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:55:37Z","timestamp":1791615337633,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>\n                      The choice of second\u2010line therapy in functional constipation (FC) is often empirical, owing to the lack of direct comparisons between agents with distinct mechanisms of action. Elobixibat, an ileal bile acid transporter inhibitor, and prucalopride, a selective 5\u2010HT\n                      <jats:sub>4<\/jats:sub>\n                      receptor agonist, represent two different therapeutic approaches targeting intestinal secretion and colonic motility. This study aimed to directly compare the efficacy of elobixibat and prucalopride in patients with FC.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this multicentre, prospective, pragmatic study with blinded outcome assessment, adults meeting Rome IV criteria for FC and refractory to first\u2010line treatment were enrolled after a standardized run\u2010in period. Participants received either elobixibat or prucalopride for 8\u2009weeks. The primary endpoint was a sustained complete spontaneous bowel movement (CSBM) response, defined as \u2265\u20093 CSBMs per week and an increase of \u2265\u20091 CSBM from baseline for at least 6 of 8\u2009weeks. Secondary outcomes included changes in stool consistency, associated symptoms and quality of life (QoL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 214 patients were included (elobixibat,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009108; prucalopride,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009106), with a mean age of 50.8\u2009\u00b1\u200917.4\u2009years and 62.6% males. Elobixibat resulted in a significantly higher sustained CSBM response compared to prucalopride (55.6% vs. 33.9%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.024), indicating a clinically meaningful benefit. Both treatments significantly improved CSBM frequency and stool consistency; however, elobixibat showed greater improvement in key symptom domains, including straining (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), abdominal discomfort (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005), bloating (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011) and QoL (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009). Both drugs were well tolerated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This head\u2010to\u2010head comparative study demonstrates that elobixibat provides superior overall symptomatic relief and quality\u2010of\u2010life improvement compared with prucalopride, potentially due to its dual mechanism of action. These findings support the consideration of IBAT inhibition as a second\u2010line treatment option in patients with FC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>Clinical Trials Registry of India: CTRI\/2025\/04\/085075<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.70828","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T03:37:07Z","timestamp":1782963427000},"page":"1071-1082","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Elobixibat Versus Prucalopride in Functional Constipation: A Prospective Comparative Effectiveness Study"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6347-0988","authenticated-orcid":false,"given":"Omesh","family":"Goyal","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Dayanand Medical College and Hospital  Ludhiana Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjeet Kumar","family":"Goyal","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Cleveland Clinic Akron General  Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhupinder","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Amar Hospital  Patiala Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajdeep","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Gastro, Liver &amp; Endoscopy Centre  Chandigarh Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prerna","family":"Goyal","sequence":"additional","affiliation":[{"name":"Department of Medicine R.G. Stone Superspeciality  Ludhiana Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varun","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Dayanand Medical College and Hospital  Ludhiana Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Kaushal","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Dayanand Medical College and Hospital  Ludhiana Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajit","family":"Sood","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Dayanand Medical College and Hospital  Ludhiana Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20101253(21)00111\u20104"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.164"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12664\u2010025\u201001808\u20101"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2016.53"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12664\u2010018\u20100894\u20101"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/CEG.S239205"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.4292\/wjgpt.v17.i1.111615"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12664\u2010025\u201001770\u2010y"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0800670"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.115"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102982.2012.01983.x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20101253(18)30123\u20107"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.285"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12664\u2010024\u201001719\u20107"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12664\u2010019\u201000953\u20108"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876\u2010023\u201003104\u20108"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.162404"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm15094"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12553"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620\u2010016\u20104147\u20109"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/onco.13879"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5534687"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.21166"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S269330"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2018.1508450"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2018.1522248"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2014.271155"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469\u20107793.1999.0317t.x"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01489324"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1159\/000540912"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.44.5.682"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41100\u2010024\u201000570\u2010y"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm20263"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.16143"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1253\/circrep.CR\u201023\u20100099"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.13972"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.780127"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13571"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm25076"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.70828","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apt.70828","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.70828","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T14:05:15Z","timestamp":1790258715000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.70828"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,1]]},"references-count":39,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/apt.70828"],"URL":"https:\/\/doi.org\/10.1111\/apt.70828","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,1]]},"assertion":[{"value":"2026-04-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}