{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T22:51:29Z","timestamp":1791845489227,"version":"4.3.4"},"reference-count":79,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Inflammatory bowel disease (IBD) is associated with renal complications, but population\u2010based data on end\u2010stage renal disease (ESRD) are limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the incidence of ESRD and renal transplantation in IBD compared with the general population and to identify predictive factors associated with ESRD in the IBD population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective population\u2010based cohort study using the University of Manitoba IBD Epidemiology Database linked to administrative healthcare data from 1984 to 2023 (12,639 IBD patients matched with 126,180 controls). ESRD was defined as requiring any two claims for outpatient dialysis within a 1\u2010year period. Predictive factors were identified using proportional hazard regression and nested case\u2013control logistic regression analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      IBD patients had a significantly higher incidence of dialysis (1.48% vs. 0.82%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) and kidney transplantation (0.25% vs. 0.10%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) than controls. IBD was an independent predictor of ESRD (HR\u2009=\u20091.53, 95% CI 1.23\u20131.90), with stronger associations in CD (HR\u2009=\u20091.93, 95% CI 1.39\u20132.68) than UC (HR\u2009=\u20091.28, 95% CI 0.96\u20131.72). Traditional risk factors including diabetes (HR\u2009=\u20093.82, 95% CI 3.22\u20134.53), hypertension (HR\u2009=\u20091.91, 95% CI 1.58\u20132.30), and congestive heart failure (HR\u2009=\u20096.37, 95% CI 5.25\u20137.72) remained strongly predictive. Within the IBD population, oral steroid treatment (OR\u2009=\u20092.0, 95% CI 1.06\u20133.81), allopurinol use (OR\u2009=\u20094.06, 95% CI 1.49\u201311.1) and bowel surgery (OR\u2009=\u20092.77, 95% CI 1.51\u20135.09) significantly predicted dialysis initiation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Persons with IBD have an increased risk of ESRD by nearly 50%, with CD showing a greater risk than UC. Bowel surgery, allopurinol use and oral steroid therapy are important predictors, emphasising the necessity of careful renal monitoring in IBD patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.70845","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T13:04:02Z","timestamp":1784034242000},"page":"1110-1122","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Inflammatory Bowel Disease Is Associated With an Increased Risk of End\u2010Stage Renal Disease: A Population\u2010Based Cohort Study"],"prefix":"10.1111","volume":"64","author":[{"given":"Onuma","family":"Sattayalertyanyong","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"},{"name":"IBD Clinical and Research Centre University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoann","family":"Nugent","sequence":"additional","affiliation":[{"name":"IBD Clinical and Research Centre University of Manitoba  Winnipeg Manitoba Canada"},{"name":"Department of Medicine, Rady Faculty of Health Sciences Max Rady College of Medicine  Winnipeg Manitoba Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryce","family":"Barr","sequence":"additional","affiliation":[{"name":"Department of Medicine, Rady Faculty of Health Sciences Max Rady College of Medicine  Winnipeg Manitoba Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keevin N.","family":"Bernstein","sequence":"additional","affiliation":[{"name":"Department of Medicine, Rady Faculty of Health Sciences Max Rady College of Medicine  Winnipeg Manitoba Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8041-3574","authenticated-orcid":false,"given":"Charles N.","family":"Bernstein","sequence":"additional","affiliation":[{"name":"IBD Clinical and Research Centre University of Manitoba  Winnipeg Manitoba Canada"},{"name":"Department of Medicine, Rady Faculty of Health Sciences Max Rady College of Medicine  Winnipeg Manitoba Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(16)31711\u20101"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.15389"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i1.91"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/07853890903559724"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i22.2702"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjy191"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/mib.0000000000000392"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836\u2010199607000\u201000009"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572\u20100241.2001.03756.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i46.17463"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12664\u2010015\u20100598\u20108"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.5217\/ir.2020.00028"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000022216"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.07.042"},{"key":"e_1_2_10_16_1","first-page":"41","article-title":"The Kidneys in Inflammatory Bowel Disease","volume":"15","author":"Katsanos K.","year":"2002","journal-title":"Annals of Gastroenterology"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21468"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjv138"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535\u2010022\u201001903\u20106"},{"issue":"3","key":"e_1_2_10_20_1","first-page":"381","article-title":"Patterns of Renal Involvement in a Cohort of Patients With Inflammatory Bowel Disease in Egypt","volume":"81","author":"Elaziz M. 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