{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:02:02Z","timestamp":1790262122302,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T00:00:00Z","timestamp":1783728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T00:00:00Z","timestamp":1783728000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background &amp; Aims<\/jats:title>\n                    <jats:p>The comparative outcomes of entecavir (ETV), tenofovir disoproxil fumarate (TDF), and tenofovir alafenamide (TAF) in patients with hepatitis B virus (HBV)\u2010related hepatocellular carcinoma (HCC) after curative resection remain unclear. This study aimed to evaluate the survival benefits of these antiviral regimens in a large real\u2010world cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We analysed 902 patients with BCLC stage 0 or A HBV\u2010related HCC who underwent curative resection between September 2001 and August 2025. Patients received ETV (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009474), TDF (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009363), or TAF (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200965) as first\u2010line therapy within 3\u2009months post\u2010resection. Inverse probability of treatment weighting (IPTW) was implemented to balance baseline covariates. The primary and secondary endpoints were overall survival (OS) and recurrence\u2010free survival (RFS).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The IPTW\u2010adjusted 5\u2010year OS rates for ETV, TDF, and TAF were 90.7%, 95.2%, and 97.1%, respectively (global\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.079). The 5\u2010year RFS rates were comparable for ETV, TDF, and TAF (57.4% vs. 61.0% vs. 69.4%; global\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.533). In multivariable Cox regression analysis, however, TDF was independently associated with a significantly lower risk of death compared with ETV (aHR 0.48; 95% CI, 0.26\u20130.89;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.021). TAF showed higher survival rates compared to ETV, although the difference did not reach statistical significance (aHR 0.34; 95% CI, 0.04\u20132.55;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.292).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The choice of antiviral regimen was not associated with RFS after curative resection for HBV\u2010related HCC, whereas TDF was independently associated with improved OS compared with ETV. Further large\u2010scale studies are warranted to validate the long\u2010term prognostic impact of TAF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.70850","type":"journal-article","created":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T14:12:44Z","timestamp":1783779164000},"page":"1123-1134","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Antiviral Therapy and Post\u2010Resection Outcomes in Patients With Hepatitis B Virus\u2010Related Hepatocellular Carcinoma"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0628-2587","authenticated-orcid":false,"given":"Jaehong","family":"Jeong","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul Korea"},{"name":"Institute of Gastroenterology, Yonsei University College of Medicine  Seoul Korea"},{"name":"Yonsei Liver Center Severance Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5768-1342","authenticated-orcid":false,"given":"Jung Pyo","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul Korea"},{"name":"Institute of Gastroenterology, Yonsei University College of Medicine  Seoul Korea"},{"name":"Yonsei Liver Center Severance Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2471-3385","authenticated-orcid":false,"given":"Dong Yun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul Korea"},{"name":"Institute of Gastroenterology, Yonsei University College of Medicine  Seoul Korea"},{"name":"Yonsei Liver Center Severance Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2371-0967","authenticated-orcid":false,"given":"Jae Seung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul Korea"},{"name":"Institute of Gastroenterology, Yonsei University College of Medicine  Seoul Korea"},{"name":"Yonsei Liver Center Severance Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5381-230X","authenticated-orcid":false,"given":"Mi Na","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul Korea"},{"name":"Institute of Gastroenterology, Yonsei University College of Medicine  Seoul Korea"},{"name":"Yonsei Liver Center Severance Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9658-8050","authenticated-orcid":false,"given":"Seung Up","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul Korea"},{"name":"Institute of Gastroenterology, Yonsei University College of Medicine  Seoul Korea"},{"name":"Yonsei Liver Center Severance Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beom Kyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul Korea"},{"name":"Institute of Gastroenterology, Yonsei University College of Medicine  Seoul Korea"},{"name":"Yonsei Liver Center Severance Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun Yong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul Korea"},{"name":"Institute of Gastroenterology, Yonsei University College of Medicine  Seoul Korea"},{"name":"Yonsei Liver Center Severance Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul Korea"},{"name":"Institute of Gastroenterology, Yonsei University College of Medicine  Seoul Korea"},{"name":"Yonsei Liver Center Severance Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3629-4624","authenticated-orcid":false,"given":"Sang Hoon","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul Korea"},{"name":"Institute of Gastroenterology, Yonsei University College of Medicine  Seoul Korea"},{"name":"Yonsei Liver Center Severance Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3552-3560","authenticated-orcid":false,"given":"Hye Won","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul Korea"},{"name":"Institute of Gastroenterology, Yonsei University College of Medicine  Seoul Korea"},{"name":"Yonsei Liver Center Severance Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.32723"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2024.0824"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2025.0043"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2024.08.028"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000466"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2022.0294"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2024.0087"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000000710"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25832"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(02)00360-4"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.48.5896"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-015-9675-4"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29800"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2025.03.018"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2024.0055"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13027-018-0191-8"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.06.011"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.03.028"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00128-15"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.18278"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.13601"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-021-10234-2"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31289"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-022-01855-x"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.40353"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2021.02.019"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.4070"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(20)30249-1"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.70850","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apt.70850","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.70850","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T14:05:07Z","timestamp":1790258707000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.70850"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,11]]},"references-count":29,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/apt.70850"],"URL":"https:\/\/doi.org\/10.1111\/apt.70850","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,11]]},"assertion":[{"value":"2026-04-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}