{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:02:01Z","timestamp":1790262121195,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Anorectal symptoms are common in ulcerative colitis (UC), yet the impact of inflammatory activity on anorectal function remains unclear. We evaluated the relationship between inflammatory activity and anorectal function and its effect on symptom development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a prospective observational study on patients with UC and active disease attending our center. Clinical, biochemical, and endoscopic assessments were performed together with high\u2010resolution anorectal manometry (HR\u2010ARM) and rectal electronic barostat testing at two time points: during active disease and 4\u20136\u2009months after treatment initiation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010six UC patients and 10 healthy volunteers were included. During active disease, fecal incontinence (FI), urgency, and tenesmus were reported by 66.7%, 91.7%, and 83.3% of patients, respectively. After treatment, symptoms improved; however, a subset of patients remained symptomatic: 32.3% still reported FI, 54.8% urgency, and 51.6% tenesmus. Greater endoscopic and histological activity correlated with lower sensory thresholds and reduced rectal capacity and compliance (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). The Mayo endoscopic subscore correlated inversely with desire to defecate volume (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u2009=\u2009\u22120.41,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014) and maximum tolerated volume (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u2009=\u2009\u22120.53,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) and positively with anal pressure during the defecatory manoeuver (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.35,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.037). Barostat parameters remained altered after treatment compared with healthy controls, including in patients who achieved histological remission.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Inflammatory activity in UC impairs anorectal function by increasing rectal sensitivity and reducing rectal compliance and capacity, contributing to persistent symptoms. Ongoing dysfunction after remission highlights the need for diagnostic and therapeutic strategies addressing anorectal involvement.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.70855","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T03:38:32Z","timestamp":1784173112000},"page":"1135-1148","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Inflammatory Activity on Anorectal Function in Patients With Ulcerative Colitis: A Prospective Study"],"prefix":"10.1111","volume":"64","author":[{"given":"Ana Sanahuja","family":"Mart\u00ednez","sequence":"first","affiliation":[{"name":"Department of Digestive Medicine Hospital Cl\u00ednic Universitari de Val\u00e8ncia, Universitat de Val\u00e8ncia  Valencia Spain"},{"name":"Institute of Health Research\u2010INCLIVA  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar Mas","family":"Mercader","sequence":"additional","affiliation":[{"name":"Department of Digestive Medicine Hospital Cl\u00ednic Universitari de Val\u00e8ncia, Universitat de Val\u00e8ncia  Valencia Spain"},{"name":"Institute of Health Research\u2010INCLIVA  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan Tosca","family":"Cuquerella","sequence":"additional","affiliation":[{"name":"Department of Digestive Medicine Hospital Cl\u00ednic Universitari de Val\u00e8ncia, Universitat de Val\u00e8ncia  Valencia Spain"},{"name":"Institute of Health Research\u2010INCLIVA  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7495-8797","authenticated-orcid":false,"given":"Marta Maia Bosc\u00e1","family":"Watts","sequence":"additional","affiliation":[{"name":"Department of Digestive Medicine Hospital Cl\u00ednic Universitari de Val\u00e8ncia, Universitat de Val\u00e8ncia  Valencia Spain"},{"name":"Institute of Health Research\u2010INCLIVA  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Rosario Ant\u00f3n","family":"Ausejo","sequence":"additional","affiliation":[{"name":"Department of Digestive Medicine Hospital Cl\u00ednic Universitari de Val\u00e8ncia, Universitat de Val\u00e8ncia  Valencia Spain"},{"name":"Institute of Health Research\u2010INCLIVA  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carles Suria","family":"Bolufer","sequence":"additional","affiliation":[{"name":"Department of Digestive Medicine Hospital Cl\u00ednic Universitari de Val\u00e8ncia, Universitat de Val\u00e8ncia  Valencia Spain"},{"name":"Institute of Health Research\u2010INCLIVA  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0708-4628","authenticated-orcid":false,"given":"V\u00edctor Merino","family":"Murgui","sequence":"additional","affiliation":[{"name":"Department of Digestive Medicine Hospital Cl\u00ednic Universitari de Val\u00e8ncia, Universitat de Val\u00e8ncia  Valencia Spain"},{"name":"Institute of Health Research\u2010INCLIVA  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Moro","family":"Valdezate","sequence":"additional","affiliation":[{"name":"Institute of Health Research\u2010INCLIVA  Valencia Spain"},{"name":"Colorectal Surgery Unit, Department of General and Digestive Surgery Hospital Cl\u00ednic Universitari de Val\u00e8ncia, Universitat de Val\u00e8ncia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie Garc\u00eda","family":"Botello","sequence":"additional","affiliation":[{"name":"Institute of Health Research\u2010INCLIVA  Valencia Spain"},{"name":"Colorectal Surgery Unit, Department of General and Digestive Surgery Hospital Cl\u00ednic Universitari de Val\u00e8ncia, Universitat de Val\u00e8ncia  Valencia 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