{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T16:33:47Z","timestamp":1793896427552,"version":"4.8.0"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["JR24\/00033"],"award-info":[{"award-number":["JR24\/00033"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003086","name":"Eusko Jaurlaritza","doi-asserted-by":"publisher","award":["2025222006"],"award-info":[{"award-number":["2025222006"]}],"id":[{"id":"10.13039\/501100003086","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The expanding use of targeted therapies in inflammatory bowel disease has made treatment sequencing increasingly relevant, yet evidence on anti\u2010TNF effectiveness after prior biologics with different mechanisms of action (MOA) remains limited. Our objective is to evaluate the durability of anti\u2010TNF treatment in this scenario.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Multicentre study based on data from the ENEIDA registry. Patients who received second\u2010line anti\u2010TNF therapy after a first biologic with a different MOA for active luminal disease were identified. Using propensity score matching, each case was matched with three controls from two cohorts: patients treated with second\u2010line anti\u2010TNF after another anti\u2010TNF and patients receiving first\u2010line anti\u2010TNF therapy. Treatment durability and short\u2010 and long\u2010term clinical effectiveness were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixty\u2010six Crohn's disease patients and 117 UC patients receiving anti\u2010TNF after other MOA were included. In CD, second\u2010line anti\u2010TNF therapy after a different MOA (62% ustekinumab) was associated with a higher risk of treatment discontinuation compared with first\u2010line anti\u2010TNF therapy (HR 1.55; 95% CI, 1.05\u20132.30), without significant differences in short\u2010 or long\u2010term clinical effectiveness. In UC, anti\u2010TNF therapy after a different MOA (90% vedolizumab) was associated with lower treatment durability compared with first\u2010line anti\u2010TNF therapy (HR 1.69; 95% CI, 1.31\u20132.19) and with anti\u2010TNF after another anti\u2010TNF agent (HR 1.91; 95% CI, 1.48\u20132.48), its remission rates significantly lower at both short\u2010 and long\u2010term follow\u2010up (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Anti\u2010TNF therapy used after a different MOA is associated with reduced effectiveness and durability compared with its use as first\u2010line therapy or after another anti\u2010TNF agent, especially in UC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.70904","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T07:35:17Z","timestamp":1786520117000},"page":"1234-1247","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Impact of Prior Biologic Mechanism of Action on Anti\u2010\n                    <scp>TNF<\/scp>\n                    Effectiveness in Inflammatory Bowel Disease: An\n                    <scp>ENEIDA<\/scp>\n                    Registry Study"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7771-6197","authenticated-orcid":false,"given":"Carmen","family":"Yag\u00fce Caballero","sequence":"first","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital Universitario Miguel Servet  Zaragoza Spain"},{"name":"Instituto de investigaci\u00f3n Sanitaria de Arag\u00f3n  Zaragoza Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3970-5457","authenticated-orcid":false,"given":"Santiago","family":"Garc\u00eda L\u00f3pez","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital Universitario Miguel Servet  Zaragoza Spain"},{"name":"Instituto de investigaci\u00f3n Sanitaria de Arag\u00f3n  Zaragoza Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Royo Esteban","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital Universitario Miguel Servet  Zaragoza Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3149-7746","authenticated-orcid":false,"given":"Laura","family":"Figueras Panillo","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital Universitario Miguel Servet  Zaragoza Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6619-1511","authenticated-orcid":false,"given":"Pilar","family":"Nos","sequence":"additional","affiliation":[{"name":"Servicio de aparato Digestivo Hospital Uniersitari i Polit\u00e8cnic La fe, Instituto de investigaci\u00f3n Sanitaria La Fe  Val\u00e8ncia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7848-7910","authenticated-orcid":false,"given":"Luisa","family":"de Castro","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital \u00c1lvaro Cunqueiro  Vigo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Dolores","family":"Mart\u00edn\u2010Arranz","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital Universiario La Paz  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5915-1477","authenticated-orcid":false,"given":"Manuel","family":"Barreiro\u2010de Acosta","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital Cl\u00ednico Universitario de Santiago de Compostela, Health Research Institute of Santiago de Compostela (IDIS)  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3354-1594","authenticated-orcid":false,"given":"Elena","family":"Ricart","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital Cl\u00ednic  Barcelona Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Centro de Investigaci\u00f3n Biom\u00e9dica en RED (CIBEREHD)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8476-1672","authenticated-orcid":false,"given":"Ruth","family":"de Francisco","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital Universitario Central de Asturias, and Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA)  Oviedo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3107-9965","authenticated-orcid":false,"given":"Eva","family":"Iglesias","sequence":"additional","affiliation":[{"name":"Servicio de Aparato digestivo Hospital Universitario Reina Sof\u00eda, IMIBIC, UCO, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD)  C\u00f3rdoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4982-2529","authenticated-orcid":false,"given":"Antonio","family":"Giordano","sequence":"additional","affiliation":[{"name":"IBD Unit, Department of Digestive Diseases Institut de Recerca Sant Pau (IR\u2010SANT PAU), Hospital de la Santa Creu i Sant Pau  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1737-3236","authenticated-orcid":false,"given":"Pilar","family":"Varela","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital Universitario de Cabue\u00f1es  Gij\u00f3n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1133-4578","authenticated-orcid":false,"given":"Iago","family":"Rodr\u00edguez\u2010Lago","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital Universitario de Galdakao, Biobizkaia Health Research Isntituto  Galdakao Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5834-1559","authenticated-orcid":false,"given":"Montserrat","family":"Rivero","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Hospital Universitario Marqu\u00e9s de Valdecilla, Grupo de Investigaci\u00f3n Cl\u00ednica y Traslacional en Enfermedades Digestivas, Instituto de Investigaci\u00f3n Valdecilla (IDIVAL)  Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4495-9358","authenticated-orcid":false,"given":"Beatriz","family":"Sicilia","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital Universitario de Burgos  Burgos Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merce","family":"Navarro\u2010Llavat","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital Mois\u00e8s Broggi  Sant Joan Desp\u00ed Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Vera","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital Universitario Puerta de Hierro  Majadahonda Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carles","family":"Suria","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital Cl\u00ednico Universitario de Valencia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0464-241X","authenticated-orcid":false,"given":"Jordi","family":"Guardiola","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital Universitari Bellvitge  L'Hospitalet de Llobregat Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7087-3921","authenticated-orcid":false,"given":"Jes\u00fas","family":"Barrio","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital R\u00edo Hortega  Valladolid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2335-3792","authenticated-orcid":false,"given":"Margalida","family":"Calafat","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital Universitari Germans Trias i Pujol, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5460-4139","authenticated-orcid":false,"given":"Ana","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital General Universitario Dr Balmis e ISABIAL, Alicante, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6278-9663","authenticated-orcid":false,"given":"Xavier","family":"Calvet","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo, Parc Taul\u00ed, Departament de Medicina Hospital Universitari, Institut d'Investigaci\u00f3 i Innovaci\u00f3 Parc Taul\u00ed, Universitat Aut\u00f2noma de Barcelona, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9124-3573","authenticated-orcid":false,"given":"David Rafael","family":"de la Cruz","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital 12 de Octubre  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7864-8187","authenticated-orcid":false,"given":"Francisco","family":"Mesonero","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital Universitario Ram\u00f3n y Cajal  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6697-6169","authenticated-orcid":false,"given":"Cristina","family":"Mart\u00ednez Pascual","sequence":"additional","affiliation":[{"name":"Servicio Aparato Digestivo Hospital Cl\u00ednico Universitario Virgen de la Arrixaca  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2090-3445","authenticated-orcid":false,"given":"Javier","family":"P. Gisbert","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS\u2010Princesa), Universidad Aut\u00f3noma de Madrid (UAM), Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3545-2707","authenticated-orcid":false,"given":"Carla J.","family":"Gargallo\u2010Puyuelo","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario Lozano Blesa de Zaragoza, IIS Arag\u00f3n  Zaragoza Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Monfort i Miquel","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Consorci Sanitari de Terrassa  Terrassa Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Sierra","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Complejo Asistencial Universitario de Le\u00f3n  Le\u00f3n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Arranz","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital Universitario Nuestra Sra. de la Candelaria  Santa Cruz de Tenerife Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3954-0736","authenticated-orcid":false,"given":"Cristina","family":"Rodr\u00edguez\u2010Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Complejo Hospitalario de Navarra  Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0709-2932","authenticated-orcid":false,"given":"Rufo","family":"Lorente","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital General Universitario de Ciudad Real  Ciudad Real Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Bermejo","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital Universitario de Fuenlabrada  Fuenlabrada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3182-9570","authenticated-orcid":false,"given":"Luc\u00eda","family":"M\u00e1rquez\u2010Mosquera","sequence":"additional","affiliation":[{"name":"Servei de Digestiu Hospital del Mar, IMIM (Hospital del Mar Medical Research Institute)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisela","family":"Torres Vicente","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital General de Granollers  Granollers Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 L\u00e1zaro","family":"P\u00e9rez\u2010Calle","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital Universitario Fundaci\u00f3n de Alcorc\u00f3n  Alcorc\u00f3n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6486-1262","authenticated-orcid":false,"given":"Jos\u00e9 M.","family":"Huguet","sequence":"additional","affiliation":[{"name":"Servicio de Patolog\u00eda digestiva Hospital General Universitario de Valencia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7015-1742","authenticated-orcid":false,"given":"Laura","family":"Ramos","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital Universitario de Canarias  La Laguna Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1176-276X","authenticated-orcid":false,"given":"\u00c1ngel","family":"Ponferrada\u2010D\u00edaz","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Hospital universitario Infanta Leonor  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2384-4524","authenticated-orcid":false,"given":"Daniel","family":"Ceballos","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo, Departamento de Ciencias M\u00e9dicas y Quir\u00fargicas Hospital Universitario de Gran Canaria Dr. Negr\u00edn, Universidad de Las Palmas  Las Palmas Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3600-8533","authenticated-orcid":false,"given":"M\u00aa. Teresa","family":"Diz\u2010Lois Palomares","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital Universitario a Coru\u00f1a  a Coru\u00f1a Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2559-4755","authenticated-orcid":false,"given":"Eva","family":"Ses\u00e9 Abizanda","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital Universitari Arnau de Vilanova  Lleida Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7545-6297","authenticated-orcid":false,"given":"Pablo","family":"Vega","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Complexo H. Universitario de Ourense  Ourense Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0549-6036","authenticated-orcid":false,"given":"Ram\u00f3n","family":"Pajares","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Universitario Infanta Sof\u00eda, Universidad Europea de Madrid  Madrid Spain"},{"name":"Faculty of Medicine, Health and Sports, Department of Medicine FIIB HUIS\u2010HUHEN  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4576-7566","authenticated-orcid":false,"given":"Javier","family":"Santos Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Complejo Hospitalario de Palencia  Palencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4636-0453","authenticated-orcid":false,"given":"Elena","family":"Betor\u00e9","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital San Jorge  Huesca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Busquets","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital Dr. Josep Trueta  Girona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Merino","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital de Cruces  Bilbao Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Mart\u00ednez\u2010Flores","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital General La Mancha Centro  Alc\u00e1zar de San Juan Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4023-8868","authenticated-orcid":false,"given":"Yamile","family":"Zabana","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital Universitari M\u00fatua Terrassa, University of Barcelona  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela Josefa","family":"Sampedro Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital de Matar\u00f3  Matar\u00f3 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jone","family":"Ortiz de Zarate","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital de Basurto  Bilbao Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Fuentes Coronel","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Complejo Asistencial de Zamora  Zamora Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Empar","family":"Sainz Arnau","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Althaia Xarxa Assistencial universitaria de Manresa  Manresa Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Carpio","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Complexo Hospitlario Universitario de Pontevedra  Pontevedra Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0043-0556","authenticated-orcid":false,"given":"Nuria","family":"Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital General Universitario de Elche  Elche Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Mar\u00edn\u2010Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo IiSGM, Hospital Gregorio Mara\u00f1\u00f3n  Madrid Spain"},{"name":"Medicine Faculty Complutense University  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Bujanda","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD)  Madrid Spain"},{"name":"Servicio de Aparato Digestivo Biodonostia Health Research Institute, Universidad del Pa\u00eds Vasco (UPV\/EHU)  San Sebasti\u00e1n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Camargo Camero","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital Virgen de la Victoria  M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5989-2678","authenticated-orcid":false,"given":"Mart\u00edn","family":"Irabien","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital Alfredo Espinosa\u2010 Urduliz  Urd\u00faliz Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5053-8269","authenticated-orcid":false,"given":"Mar\u00eda","family":"Abanades Tercero","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital Universitario de Toledo  Toledo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benito","family":"Velayos Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital Cl\u00ednico Universitario de Valladolid, Instituto de Investigaci\u00f3n Biosanitaria de Valladolid (IBioVALL)  Valladolid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Robledo Andres","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital Universitario de C\u00e1ceres  C\u00e1ceres Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Mar\u00eda","family":"Trapero","sequence":"additional","affiliation":[{"name":"Servicio Aparato Digestivo Complejo Hospitalario de Ja\u00e9n  Ja\u00e9n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5798-5491","authenticated-orcid":false,"given":"Pedro G.","family":"Delgado\u2010Guillena","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital de M\u00e9rida  M\u00e9rida Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9175-4312","authenticated-orcid":false,"given":"Lu\u00eds","family":"Hern\u00e1ndez Villalba","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital Santos Reyes  Aranda del Duero Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Menacho","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital Joan XXIII  Tarragona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Rull Murillo","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital Son Ll\u00e0tzer  Manacor Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0941-2661","authenticated-orcid":false,"given":"Carles","family":"Leal","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Consorci Hospitalari de Vic, Universitat de Vic\u2010UCC  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Alba","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital Cl\u00ednico San Carlos and Instituto de Investigaci\u00f3n del Hospital Cl\u00ednico San Carlos [IdISSC]  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"G\u00f3mez Esp\u00edn","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital General Universitario Reina Sof\u00eda  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1183-1072","authenticated-orcid":false,"given":"Alfredo J.","family":"Lucendo","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital General de Tomelloso. Instituto de Investigaci\u00f3n Sanitaria de Castilla\u2010La Mancha (IDISCAM), Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9950-2216","authenticated-orcid":false,"given":"Manuel","family":"Van Domselaar","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital Universitario de Torrej\u00f3n, Universidad Francisco de Vitoria  Torrej\u00f3n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7843-2127","authenticated-orcid":false,"given":"Laura","family":"Garc\u00eda Alles","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital Sierrallana  Torrelavega Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Iyo Miyashiro","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital de Inca  Inca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Crespo Catal\u00e1","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital de Denia  Denia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pau","family":"Gilabert","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital de Viladecans  Viladecans Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8201-9180","authenticated-orcid":false,"given":"Daniel","family":"Mart\u00edn Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital Universitario Infanta Cristina  Parla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3004-252X","authenticated-orcid":false,"given":"V\u00edctor Manuel","family":"Navas\u2010L\u00f3pez","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Gastroenterolog\u00eda y Nutrici\u00f3n Infantil Hospital Regional Universitario de M\u00e1laga  M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9862-2427","authenticated-orcid":false,"given":"Mar\u00eda","family":"Calvo I\u00f1iguez","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital de San Pedro  Logro\u00f1o Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Ginard","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital Son Espases  Palma de Mallorca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1304-3936","authenticated-orcid":false,"given":"Teresa","family":"Mart\u00ednez P\u00e9rez","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital Virgen de la Luz  Cuenca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2315-7196","authenticated-orcid":false,"given":"Eugeni","family":"Dom\u00e8nech","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital Universitari Germans Trias i Pujol, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6883-8940","authenticated-orcid":false,"given":"Diego","family":"Casas Deza","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital Universitario Miguel Servet  Zaragoza Spain"},{"name":"Instituto de investigaci\u00f3n Sanitaria de Arag\u00f3n  Zaragoza Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)02586-2"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.18553\/jmcp.2021.27.8.1046"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v29.i10.1539"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2018.07.013"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002152"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjad108"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izad245"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40273-018-0653-2"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjad124"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13083"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastrohep.2020.05.007"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198712243172603"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(80)92767-1"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.030"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050516"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1905725"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)00688-2"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2023.01.013"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjad184"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.15389"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.04.022"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.4321\/S1130-01082012000900004"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000001109"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.02.004"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastrohep.2016.02.004"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000003670"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjad203"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjz212"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-315671"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjac007"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(18)30265-6"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.70904","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apt.70904","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.70904","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:14:24Z","timestamp":1791558864000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.70904"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,12]]},"references-count":31,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["10.1111\/apt.70904"],"URL":"https:\/\/doi.org\/10.1111\/apt.70904","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,12]]},"assertion":[{"value":"2026-03-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}