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Coeliac disease was screened in 6339 individuals by transglutaminase and endomysial antibodies, with dual seropositivity as the diagnostic criterion, histologically validated in this cohort. Survey\u2010weighted analyses enabled population\u2010level results. The follow\u2010up cohort comprised those participating in both time points. Mortality was assessed between 2000 and 2017.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At screening, 92 (1.5%) undiagnosed coeliac disease patients and 6216 non\u2010coeliac controls were identified. Patients were less often smokers (11% vs. 22%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014), more often had a history of pre\u2010eclampsia (13% vs. 5%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.037) and anaemia (14% vs. 6%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012), and lower ferritin (29 vs. 68\u2009ng\/mL,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), with an altered lipid profile including lower total cholesterol, LDL\u2010C, and ApoB but higher atherogenic ratios. At 11\u2010year follow\u2010up, mental health, quality of life, and cardiometabolic markers were comparable between treated coeliac disease patients (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200950) and non\u2010coeliac controls (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20093226). Mortality did not differ after adjustment for age and sex (HR 0.77, 95% CI 0.45\u20131.33).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Nationally screened adults with undiagnosed coeliac disease showed iron deficiency and anaemia. Long\u2010term dietary treatment did not adversely affect quality of life or cardiometabolic health and may prevent complications. Furthermore, mortality was comparable to the general population. The results suggest a favourable benefit\u2010harm balance for population\u2010based screening.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.70917","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T14:07:01Z","timestamp":1786370821000},"page":"1248-1259","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Screen\u2010Detected Coeliac Disease in a Nationally Representative Cohort: Health Indicators, Long\u2010Term Outcomes and Mortality"],"prefix":"10.1111","volume":"64","author":[{"given":"Iida","family":"Ahonen","sequence":"first","affiliation":[{"name":"Celiac Disease Research Centre Tampere University  Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4757-2164","authenticated-orcid":false,"given":"Kalle","family":"Kurppa","sequence":"additional","affiliation":[{"name":"Celiac Disease Research Centre Tampere University  Tampere Finland"},{"name":"Tampere Centre for Child, Adolescent and Maternal Health Research Tampere University  Tampere Finland"},{"name":"Department of Pediatrics Tampere University Hospital, Well\u2010Being Services County of Pirkanmaa  Tampere Finland"},{"name":"The University Consortium of Sein\u00e4joki  Sein\u00e4joki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1372-430X","authenticated-orcid":false,"given":"Heini","family":"Huhtala","sequence":"additional","affiliation":[{"name":"Faculty of Social Sciences University of Tampere  Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5046-8133","authenticated-orcid":false,"given":"Katri","family":"Kaukinen","sequence":"additional","affiliation":[{"name":"Celiac Disease Research Centre Tampere University  Tampere Finland"},{"name":"Department of Internal Medicine Tampere University Hospital, Well\u2010Being Services County of Pirkanmaa  Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7959-7628","authenticated-orcid":false,"given":"Laura","family":"Kivel\u00e4","sequence":"additional","affiliation":[{"name":"Celiac Disease Research Centre Tampere University  Tampere Finland"},{"name":"Children's Hospital and Pediatric Research Centre University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3948-9555","authenticated-orcid":false,"given":"Juha","family":"Taavela","sequence":"additional","affiliation":[{"name":"Celiac Disease Research Centre Tampere University  Tampere Finland"},{"name":"Department of Gastroenterology and Alimentary Tract Surgery Tampere University Hospital, Well\u2010Being Services County of Pirkanmaa  Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(22)00794\u20102"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2017.06.037"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.07.057"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2015.05.004"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.11.043"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpg.0000450393.23156.59"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.17803"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102013\u2010306578"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640619844125"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002075"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002497"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20108587(23)00354\u20106"},{"key":"e_1_2_14_14_1","volume-title":"Principles and Practice of Screening for Disease","author":"Wilson J. 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