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The primary outcome was the accuracy of anti\u2010integrin \u03b1v\u03b26 antibodies in distinguishing UC from CD. Secondary analyses compared their performance with ASCA and ANCA status and across IBD subgroups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 224 patients were included (UC:\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009106, CD:\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009118, male: 63.8%, median age: 43.5\u2009years). Patients with indeterminate colitis were excluded. At a cut\u2010off of 2.44\u2009U\/mL, anti\u2010integrin \u03b1v\u03b26 autoantibodies demonstrated a diagnostic accuracy of 86.5%, with a sensitivity of 85.8% and specificity of 87.1%. In a multivariate logistic regression analysis, these autoantibodies were independently associated with UC (OR 36.18, 95% CI 17.0\u201383.0,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20094.86\u2009\u00d7\u200910\n                      <jats:sup>\u221219<\/jats:sup>\n                      ) and demonstrated superior diagnostic performance compared to ANCA and ASCA status (Akaike information criterion 184.8 vs. 252.4). Positivity rates followed a gradient across the Montreal classification, increasing from ileal (L1: 7.9%) and ileocolonic (L3: 8.1%) CD towards colonic CD (L2: 43.8%) and UC: 85.8% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20092.04\u2009\u00d7\u200910\n                      <jats:sup>\u221231<\/jats:sup>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Anti\u2010integrin \u03b1v\u03b26 autoantibodies demonstrate high diagnostic accuracy and outperform conventional serological markers in distinguishing UC from CD. Importantly, this study provides the first direct comparison with ANCA and ASCA status within the same patient cohort.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.70926","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T13:41:42Z","timestamp":1787233302000},"page":"1260-1273","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Anti\u2010Integrin\n                    <scp>\u03b1v\u03b26<\/scp>\n                    Autoantibodies Distinguish Ulcerative Colitis From Crohn's Disease With High Diagnostic Accuracy and Outperform\n                    <scp>ANCA<\/scp>\n                    and\n                    <scp>ASCA<\/scp>\n                    Status: A Prospective Cross\u2010Sectional Study"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5708-0975","authenticated-orcid":false,"given":"Samuel","family":"Truniger","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology HOCH Health Ostschweiz  St. Gallen Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Waber","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine HOCH Health Ostschweiz  St. Gallen Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"D\u00fctschler","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology HOCH Health Ostschweiz  St. Gallen Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius","family":"K\u00f6nig","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology HOCH Health Ostschweiz  St. Gallen 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