{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:52:44Z","timestamp":1791561164067,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","award":["214524"],"award-info":[{"award-number":["214524"]}],"id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2026,11]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Pruritus is a common and burdensome symptom in patients with primary sclerosing cholangitis (\n PSC<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Aims<\/jats:title>\n \n To determine the prevalence of pruritus in\n PSC<\/jats:styled-content>\n , its clinical associations, and its impact on quality of life.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Patients with\n PSC<\/jats:styled-content>\n were assessed for pruritus using the Worst Itch Numerical Rating Scale (\n WI<\/jats:styled-content>\n \u2010\n NRS<\/jats:styled-content>\n ) and 5\u2010D Itch scale, and for quality of life using\n SF<\/jats:styled-content>\n \u201036 and\n PSC<\/jats:styled-content>\n \u2010\n PRO<\/jats:styled-content>\n . Participants reporting moderate to severe pruritus (\n WI<\/jats:styled-content>\n \u2010\n NRS<\/jats:styled-content>\n \u2265\u20094) within 6\u2009months of enrollment completed longitudinal assessments for up to 6\u2009months. Those with inflammatory bowel disease (\n IBD<\/jats:styled-content>\n ) completed the Simple Clinical Colitis Activity Index (P\u2010\n SCCAI<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Median age was 43\u2009years, 61% were male and 75% had\n IBD<\/jats:styled-content>\n . Moderate to severe itch over the prior 7\u2009days was reported by 24%, increasing to 38% over the prior 6\u2009months. Greater pruritus was associated with cirrhosis (\n p<\/jats:italic>\n \u2009=\u20090.01), alkaline phosphatase (\n p<\/jats:italic>\n \u2009=\u20090.0001), total bilirubin (\n p<\/jats:italic>\n \u2009=\u20090.0006) and lower albumin (\n p<\/jats:italic>\n \u2009=\u20090.01). Among patients with\n IBD<\/jats:styled-content>\n , itch severity was associated with colitis activity (\n p<\/jats:italic>\n \u2009=\u20090.01). Pruritus associated with impaired quality of life on the\n SF<\/jats:styled-content>\n \u201036 (\n r<\/jats:italic>\n s<\/jats:sub>\n \u2009=\u2009\u22120.47) and\n PSC<\/jats:styled-content>\n \u2010\n PRO<\/jats:styled-content>\n (\n r<\/jats:italic>\n s<\/jats:sub>\n \u2009=\u20090.69). Longitudinally, pruritus varied markedly with 86.5% of patients reporting moderate to severe pruritus in the past 6\u2009months experiencing severe itch at least once over 6\u2009months.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Pruritus is common, clinically meaningful and fluctuates over time in\n PSC<\/jats:styled-content>\n . Its strong impact on quality\u2010of\u2010life underscores the need for standardized assessment and development of more effective therapies.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/apt.70931","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:48:17Z","timestamp":1787024897000},"page":"1288-1297","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pruritus Is Frequent and Persistent and Impacts Quality of Life Among Patients With Primary Sclerosing Cholangitis"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7438-8204","authenticated-orcid":false,"given":"Richard","family":"Dean","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of California Davis Sacramento California 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