{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T21:34:17Z","timestamp":1792704857677,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["5954150:I"],"award-info":[{"award-number":["5954150:I"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2026,11]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n People with irritable bowel syndrome (IBS) often restrict their intake of FODMAPs because of associated gas and abdominal discomfort. Psyllium, a gel\u2010forming fibre, reduces colonic gas after inulin ingestion.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n We aimed to determine whether methylcellulose, a low\u2010cost, non\u2010fermentable gelling agent, widely used in food manufacture, could be formulated to match psyllium's physical properties and similarly moderate colonic fermentation of inulin.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n 3\u2010way randomised cross\u2010over study giving 15\u2009g inulin with 15\u2009g methylcellulose, psyllium or maltodextrin (placebo) in 22 healthy volunteers. Participants underwent hourly MRI scans for 6\u2009h and serial breath hydrogen measurements for 24\u2009h when a final MRI scan was performed.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Methylcellulose and psyllium gels did not significantly alter AUC\n 0\u2013360\u2009min<\/jats:sub>\n , however, they were associated with less colonic gas after the gels reached the colon (AUC\n 180\u2013360\u2009min<\/jats:sub>\n ,\n p<\/jats:italic>\n \u2009=\u20090.02). The gels increased AUC\n 0\u2013240\u2009min<\/jats:sub>\n of small bowel free water (\n p<\/jats:italic>\n \u2009<\u20090.0001 and 0.048, respectively), methylcellulose effect>psyllium (\n p<\/jats:italic>\n \u2009=\u20090.0005). Both increased colon chyme wateriness (T1AC, AUC\n 180\u2013360\u2009min<\/jats:sub>\n ,\n p<\/jats:italic>\n \u2009<\u20090.0001) and volume of hydrated fibre in colon (AUC\n 180\u2013360\u2009min<\/jats:sub>\n ,\n p<\/jats:italic>\n \u2009<\u20090.0001 and 0.0009, respectively). Both parameters were greater after methylcellulose than psyllium (\n p<\/jats:italic>\n \u2009=\u20090.01 and 0.02, respectively). 24\u2009h measurements of breath hydrogen were not different between groups (AUC\n 0\u201324\u2009h<\/jats:sub>\n ,\n p<\/jats:italic>\n \u2009=\u20091.0) but were reduced by psyllium in the 0\u20136\u2010h period\n p<\/jats:italic>\n \u2009=\u20090.008.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Methylcellulose and psyllium reduce colonic gas produced by inulin after the gels reach the colon. Methylcellulose increases the water content of both the small and large bowel more than psyllium. This additional effect may allow improved tolerance of FODMAPs, particularly in IBS patients with constipation.<\/jats:p>\n \n Trial Registration:<\/jats:bold>\n ClinicalTrials.gov<\/jats:ext-link>\n identifier: NCT06291272\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/apt.70964","type":"journal-article","created":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T04:37:23Z","timestamp":1789187843000},"page":"1197-1206","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical Trial: Randomised Placebo\u2010Controlled Trial of Methylcellulose and Psyllium Gels on Inulin\u2010Induced Colonic Gas"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5483-1684","authenticated-orcid":false,"given":"Neele","family":"Dellschaft","sequence":"first","affiliation":[{"name":"Sir Peter Mansfield Imaging Centre University of Nottingham Nottingham UK"},{"name":"Nottingham NIHR Biomedical Research Centre University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1571-0975","authenticated-orcid":false,"given":"Alaa","family":"Alhasani","sequence":"additional","affiliation":[{"name":"Nottingham NIHR Biomedical Research Centre University of Nottingham Nottingham UK"},{"name":"Nottingham Digestive Diseases Centre University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3187-2437","authenticated-orcid":false,"given":"Joshua E. S. J.","family":"Reid","sequence":"additional","affiliation":[{"name":"Nottingham NIHR Biomedical Research Centre University of Nottingham Nottingham UK"},{"name":"Division of Food, Nutrition and Dietetics University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5483-1027","authenticated-orcid":false,"given":"Caroline L.","family":"Hoad","sequence":"additional","affiliation":[{"name":"Sir Peter Mansfield Imaging Centre University of Nottingham Nottingham UK"},{"name":"Nottingham NIHR Biomedical Research Centre University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Gates","sequence":"additional","affiliation":[{"name":"Nottingham NIHR Biomedical Research Centre University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly","family":"Whymark","sequence":"additional","affiliation":[{"name":"Nottingham NIHR Biomedical Research Centre University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5420-9422","authenticated-orcid":false,"given":"Gleb","family":"Yakubov","sequence":"additional","affiliation":[{"name":"School of Food Science and Nutrition University of Leeds Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9092-4300","authenticated-orcid":false,"given":"Luca","family":"Marciani","sequence":"additional","affiliation":[{"name":"Nottingham NIHR Biomedical Research Centre University of Nottingham Nottingham UK"},{"name":"Nottingham Digestive Diseases Centre University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2512-4670","authenticated-orcid":false,"given":"Frederick J.","family":"Warren","sequence":"additional","affiliation":[{"name":"Quadram Institute Bioscience Norwich UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3563-4874","authenticated-orcid":false,"given":"Amisha","family":"Modasia","sequence":"additional","affiliation":[{"name":"Quadram Institute Bioscience Norwich UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abi","family":"Spicer","sequence":"additional","affiliation":[{"name":"Sir Peter Mansfield Imaging Centre University of Nottingham Nottingham UK"},{"name":"Nottingham NIHR Biomedical Research Centre University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6794-6621","authenticated-orcid":false,"given":"Colin","family":"Crooks","sequence":"additional","affiliation":[{"name":"Nottingham NIHR Biomedical Research Centre University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2957-4684","authenticated-orcid":false,"given":"Maura","family":"Corsetti","sequence":"additional","affiliation":[{"name":"Nottingham NIHR Biomedical Research Centre University of Nottingham Nottingham UK"},{"name":"Nottingham Digestive Diseases Centre University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4900-4817","authenticated-orcid":false,"given":"Penny A.","family":"Gowland","sequence":"additional","affiliation":[{"name":"Sir Peter Mansfield Imaging Centre University of Nottingham Nottingham UK"},{"name":"Nottingham NIHR Biomedical Research Centre University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6371-4500","authenticated-orcid":false,"given":"Robin","family":"Spiller","sequence":"additional","affiliation":[{"name":"Nottingham NIHR Biomedical Research Centre University of Nottingham Nottingham UK"},{"name":"Nottingham Digestive Diseases Centre University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.386"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.09.062"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102021\u2010324784"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5FO03532E"},{"key":"e_1_2_12_6_1","doi-asserted-by":"crossref","unstructured":"M. J.McAuliffe F. M.Lalonde D.McGarry et\u00a0al. \u201cMedical Image Processing Analysis and Visualization in Clinical Research \u201dIn: Proceedings 14th IEEE Symposium on Computer\u2010Based Medical Systems. CBMS 2001 Bethesda MD USA: IEEE Comput. Soc (2001) 381\u2013386 http:\/\/ieeexplore.ieee.org\/document\/941749\/.","DOI":"10.1109\/CBMS.2001.941749"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12243"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2025.07.008"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/52\/23\/009"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.16673"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14999"},{"issue":"2","key":"e_1_2_12_12_1","first-page":"39","article-title":"Breath Tests for the Assessment of the Orocecal Transit Time","volume":"17","author":"Scarpellini E.","year":"2013","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-215-44139"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002619900340"},{"key":"e_1_2_12_15_1","doi-asserted-by":"crossref","unstructured":"A. A.Modasia J. E. S. J.Reid A. T.Alhasani et\u00a0al. \u201cGel\u2010Forming Fibres Differentially Modulate Inulin Fermentation: A Comparison of Psyllium and Methylcellulose in In\u00a0Vitro Colonic Models \u201dBioRxiv (2026).","DOI":"10.64898\/2026.04.07.717018"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2012.01926.x"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00316.2020"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.45.6.840"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.17629"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13400"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114520003943"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.35.12.1747"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.11.006"},{"key":"e_1_2_12_24_1","volume-title":"Cellulose and Cellulose Derivatives","author":"Kamide K.","year":"2005"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114517003440"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/trfood\/vxaf021"}],"container-title":["Alimentary Pharmacology & Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.70964","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apt.70964","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.70964","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:14:12Z","timestamp":1791558852000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.70964"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,11]]},"references-count":25,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["10.1111\/apt.70964"],"URL":"https:\/\/doi.org\/10.1111\/apt.70964","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,11]]},"assertion":[{"value":"2026-08-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}