{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T11:43:05Z","timestamp":1792669385897,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82570631"],"award-info":[{"award-number":["82570631"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005090","name":"Beijing Nova Program","doi-asserted-by":"publisher","award":["20230484349"],"award-info":[{"award-number":["20230484349"]}],"id":[{"id":"10.13039\/501100005090","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Long\u2010term adverse liver and oncological risks across steatotic liver disease (SLD) subtypes remain uncertain, and alcohol underreporting may cause misclassification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate long\u2010term risks of major adverse liver outcomes (MALO) and cancer across SLD subtypes by the MetALD\u2010ALD Prediction Index (MAPI) and self\u2010reported alcohol intake.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants with SLD at baseline and free of cancer in the UK Biobank were classified as MASLD, MetALD, or ALD. The primary outcome was incident MALO. Secondary outcomes included incident all cancers, cancer\u2010related death, hepatocellular carcinoma (HCC), extrahepatic cancers, digestive cancers excluding HCC, and site\u2010specific digestive cancers. Multivariable Cox models estimated hazard ratios (HRs) and 95% confidence intervals (CIs), with MASLD as the reference group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 138,996 participants, 51,633 were classified as MASLD, 27,231 as MetALD, and 60,132 as ALD. Compared with MASLD, MetALD exhibited higher risks of all cancers (HR, 1.07; 95% CI, 1.04\u20131.11) and extrahepatic cancers (HR, 1.07; 95% CI, 1.03\u20131.11), but not of MALO, cancer\u2010related death, HCC, or digestive cancers excluding HCC. ALD showed the greatest risks, with increased risks of MALO (HR, 1.70; 95% CI, 1.54\u20131.88), all cancers (HR, 1.12; 95% CI, 1.08\u20131.15), cancer\u2010related death (HR, 1.07; 95% CI, 1.01\u20131.14), HCC (HR, 3.07; 95% CI, 2.23\u20134.23), extrahepatic cancers (HR, 1.11; 95% CI, 1.08\u20131.14), and digestive cancers excluding HCC (HR, 1.20; 95% CI, 1.11\u20131.29).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>MAPI\u2010informed SLD subtypes showed distinct risk profiles. MetALD exhibited higher risks of all cancers and extrahepatic cancers, whereas ALD conferred the highest risks across MALO and cancer outcomes, particularly for HCC and digestive cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.70967","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T07:47:15Z","timestamp":1788767235000},"page":"1448-1461","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Long\u2010Term Major Adverse Liver Outcomes and Oncological Outcomes Across Steatotic Liver Disease Subtypes Classified Using the\n                    <scp>MetALD<\/scp>\n                    \u2010\n                    <scp>ALD<\/scp>\n                    Prediction Index"],"prefix":"10.1111","volume":"64","author":[{"given":"Yuge","family":"Li","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Beijing Friendship Hospital, Capital Medical University  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