{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T09:55:10Z","timestamp":1791366910887,"version":"4.3.1"},"reference-count":17,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Linaprazan glurate (LG), a potassium\u2010competitive acid blocker (PCAB), has shown up to 100% and 93% 4\u2010week healing rates in a Phase 2 study in patients with LA grade A\/B and C\/D erosive oesophagitis, respectively.<\/jats:p>\n <\/jats:sec>\n \n Aim<\/jats:title>\n To assess the Pharmacodynamic (PD) effect and Pharmacokinetics (PK) of multiple\u2010dose administration of LG.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n In the open, randomised, parallel\u2010group, Phase 1 study, PD (intragastric pH) and PK were investigated after the first dose and 14\u2009days of repeated administration of LG at dose levels 25, 50 and 75\u2009mg q. d. and 25, 50 and 75\u2009mg b.d.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 73 subjects were treated with LG during the study. After the first LG dose, pH >\u20094 was achieved within 60 and 10\u2009min for the 50\u2009mg b.d. and 75\u2009mg b.d. dose groups, respectively. Dose\u2013response was observed for HTRs at pH >\u20094, with >\u200990% for 50\u2009mg b.d. and 75\u2009mg b.d. on Day 1 and\u2009>\u200995% on Day 14. HTR was higher with 25\u2009mg b.d. than with 50\u2009mg q. d. both on Day 1 and Day 14. Mean AUC and mean C\n max<\/jats:sub>\n for linaprazan, the main LG metabolite, increased approximately in proportion to dose with no apparent accumulation.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n LG provided a rapid increase in gastric pH after the first dose, with an HTR pH >\u20094 close to 100% for dose levels 50\u2009mg b.d. and 75\u2009mg b.d. Linaprazan AUC and C\n max<\/jats:sub>\n increased in proportion to LG dose. LG was safe and well tolerated at the studied dose levels.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/apt.70980","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:13:07Z","timestamp":1790838787000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical trial: The Effect on Intragastric\n pH<\/scp>\n and Pharmacokinetics of the\n PCAB<\/scp>\n Linaprazan Glurate in Healthy Subjects After Repeat\u2010Dose Administration for up to 14\u2009Days"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8017-6360","authenticated-orcid":false,"given":"Kajsa","family":"Larsson","sequence":"first","affiliation":[{"name":"Cinclus Pharma Holding AB (Publ) Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kjell","family":"Andersson","sequence":"additional","affiliation":[{"name":"Cinclus Pharma Holding AB (Publ) Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunilla","family":"Huledal","sequence":"additional","affiliation":[{"name":"Cinclus Pharma Holding AB (Publ) Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2703-0798","authenticated-orcid":false,"given":"Jouni","family":"Junnila","sequence":"additional","affiliation":[{"name":"EstiMates Oy Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristofer","family":"Katkits Nilsson","sequence":"additional","affiliation":[{"name":"Cinclus Pharma Holding AB (Publ) Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3215-402X","authenticated-orcid":false,"given":"Elham","family":"Yektaei","sequence":"additional","affiliation":[{"name":"Cinclus Pharma Holding AB (Publ) Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matja\u017e","family":"Fle\u017ear","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Ljubljana Ljubljana Slovenia"},{"name":"University Clinic of Respiratory and Allergic Diseases Golnik Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Unge","sequence":"additional","affiliation":[{"name":"Cinclus Pharma Holding AB (Publ) Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001538"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00630.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000200917"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.159.7.649"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/psp4.13235"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.17.s1.3.x"},{"issue":"4","key":"e_1_2_9_8_1","first-page":"244","article-title":"The Role of pH in Symptomatic Relief and Effective Treatment of Gastroesophageal Reflux Disease","volume":"12","author":"Gasiorowska A.","year":"2017","journal-title":"Przeglad 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