{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T07:45:09Z","timestamp":1791791109095,"version":"4.3.4"},"reference-count":40,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI16\/01296"],"award-info":[{"award-number":["PI16\/01296"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PFI17\/00143"],"award-info":[{"award-number":["PFI17\/00143"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022752","name":"MSD Sharp and Dohme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100022752","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022924","name":"Grupo Espa\u00f1ol de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100022924","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aimed to describe the characteristics of newly diagnosed inflammatory bowel disease (IBD) patients and to analyse their clinical course within the first 5\u2009years after diagnosis, including the need for surgery, hospitalisations and treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective and large multicentre incident cohort registry in Spain enrolled adults diagnosed with Crohn's disease (CD), ulcerative colitis (UC) or unclassified IBD (IBD\u2010U) in 2017 and followed them for 5\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 3301 patients were enrolled: 1526 with CD, 1633 with UC and 142 with IBD\u2010U. Their median age at diagnosis was 43\u2009years (interquartile range 31\u201356) and approximately 50% were male. Within 5\u2009years post\u2010diagnosis, 30% received biologics or JAK inhibitors (JAKi), 34% were hospitalised at least once and 9% underwent surgery. The cumulative incidence of biologic\/JAKi treatment, hospitalisations and surgeries was higher among CD patients. Use of biologics\/JAKi correlated with a more aggressive CD phenotype, greater UC extent and younger age at diagnosis. Biologics\/JAKi treatment was associated with lower hospitalisation risk in both CD (Hazard ratio [HR]\u2009=\u20090.4, 95% confidence interval [CI]\u2009=\u20090.2\u20130.6) and UC patients (HR\u2009=\u20090.5, 95% CI\u2009=\u20090.2\u20130.9). However, it was not associated with the risk of abdominal surgery in CD but was linked to an increased risk of surgery in UC (HR\u2009=\u200911.9, 95% CI\u2009=\u20094.6\u201330.4).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This large multicentre cohort demonstrated a higher use of biologics\/JAKi during the first 5\u2009years after IBD diagnosis than previously reported. Treatment with biologics\/JAKi was associated with reduced risk of hospitalisation. However, under current clinical practice patterns, this therapeutic approach did not translate into lower risk of abdominal surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.70987","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T06:49:27Z","timestamp":1791787767000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Course and Predictors of Biologic Therapy, Hospitalisation and Surgery: A Five\u2010Year Prospective Study in Newly Diagnosed Inflammatory Bowel Disease"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7960-3515","authenticated-orcid":false,"given":"Ana","family":"Garre","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS\u2010Princesa), Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD), Hospital Universitario de La Princesa, Universidad Aut\u00f3noma de Madrid (UAM)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Nu\u00f1ez Ortiz","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Universitario Virgen del Roc\u00edo  Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saioa","family":"Rubio","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Universitario de Navarra  Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3600-8533","authenticated-orcid":false,"given":"Mar\u00eda Teresa","family":"Diz\u2010Lois Palomares","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Universitario A Coru\u00f1a  A Coru\u00f1a Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9383-3698","authenticated-orcid":false,"given":"Sabino","family":"Riestra","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, ISPA Hospital Universitario Central de Asturias  Oviedo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horacio","family":"Alonso\u2010Gal\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Instituto Biogipuzkoa Hospital Universitario Donostia  San Sebasti\u00e1n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estela","family":"Fern\u00e1ndez\u2010Salgado","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Instituto de Investigaci\u00f3n Sanitaria Galicia Sur, Complexo Hospitalario Universitario de Pontevedra  Pontevedra Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0469-4332","authenticated-orcid":false,"given":"Roc\u00edo","family":"Ferreiro\u2010Iglesias","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Fundaci\u00f3n Instituto de Investigaci\u00f3n Sanitaria de Santiago de Compostela (FIDIS), Complexo Hospitalario Universitario de Santiago  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4537-9133","authenticated-orcid":false,"given":"Milagros","family":"Vela","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Complejo Hospitalario Universitario Ntra. 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