{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:13:00Z","timestamp":1791324780867,"version":"4.3.1"},"reference-count":51,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Patients with eosinophilic oesophagitis (EoE) can present with differing disease characteristics, treatment resistance, and associated type 2 inflammatory comorbidities. We assessed the efficacy of dupilumab in subgroups of patients with EoE from the LIBERTY EoE TREET study across a range of demographics, characteristics, treatments, and comorbidities.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Patients were categorised by subgroups based on weight (<\u200960\u2009kg or \u2265\u200960\u2009kg), body mass index (<\u200918.5\u2009kg\/m\n 2<\/jats:sup>\n , \u2265\u200918.5 to <\u200930\u2009kg\/m\n 2<\/jats:sup>\n , \u2265\u200930\u2009kg\/m\n 2<\/jats:sup>\n ), disease duration before study entry (<\u20095\u2009years, \u2265\u20095 to <\u200910\u2009years, \u2265\u200910\u2009years), history of type 2 inflammatory comorbidities (with\/without asthma, allergic rhinitis, atopic dermatitis, or food allergy), history of elimination diet, concurrent elimination diet, concurrent proton pump inhibitor use, and prior oesophageal dilation. Outcomes were analysed post hoc and included the proportion of patients achieving \u2264\u20096 eosinophils per high\u2010power field (eos\/hpf) and change from baseline in Dysphagia Symptom Questionnaire (DSQ) and total Endoscopic Reference Score (EREFS).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n At Week 24, dupilumab treatment increased the proportion of patients achieving histological remission (peak eosinophil count \u2264\u20096 eos\/hpf) versus placebo in all subgroups. At Week 52, improvements were maintained with continued dupilumab treatment. Improvements were also observed through Week 52 in patients who switched from placebo to dupilumab at Week 24. Similar results were observed for change from baseline in DSQ and EREFS.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Dupilumab treatment improved histological, symptomatic, and endoscopic outcomes versus placebo in patients with EoE, regardless of demographics, disease characteristics, treatment history, or type 2 inflammatory disease comorbidities.<\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n ClinicalTrials.gov identifier: NCT03633617<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/apt.71001","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:13:46Z","timestamp":1791281626000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical Trial: Dupilumab Improves Eosinophilic Oesophagitis Outcomes Versus Placebo Regardless of Comorbidities or Treatment History in a Randomised Clinical Trial"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1167-1101","authenticated-orcid":false,"given":"Evan S.","family":"Dellon","sequence":"first","affiliation":[{"name":"Center for Esophageal Diseases and Swallowing University of North Carolina School of Medicine Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc E.","family":"Rothenberg","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center University of Cincinnati College of Medicine Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4658-5353","authenticated-orcid":false,"given":"Jonathan M.","family":"Spergel","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology, Children's Hospital of Philadelphia, Department of Pediatrics Perelman School of Medicine at University of Pennsylvania School of Medicine Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert J.","family":"Bredenoord","sequence":"additional","affiliation":[{"name":"Amsterdam University Medical Center Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Cianferoni","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Perelman School of Medicine at the University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5703-5074","authenticated-orcid":false,"given":"Changming","family":"Xia","sequence":"additional","affiliation":[{"name":"Regeneron Pharmaceuticals Inc. Tarrytown New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margee","family":"Louisias","sequence":"additional","affiliation":[{"name":"Sanofi Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0736-8115","authenticated-orcid":false,"given":"Allen","family":"Radin","sequence":"additional","affiliation":[{"name":"Regeneron Pharmaceuticals Inc. Tarrytown New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"issue":"2","key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1053\/j.gastro.2017.06.067","article-title":"Epidemiology and Natural History of Eosinophilic Esophagitis","volume":"154","author":"Dellon E. 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