{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T08:59:51Z","timestamp":1790672391811,"version":"4.1.0"},"reference-count":92,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Chronic hepatitis B virus (HBV) infection remains a major cause of hepatocellular carcinoma (HCC). Although antiviral therapy reduces cirrhosis and liver failure, HCC may still develop in patients with HBV, including in non\u2010cirrhotic livers. This review aimed to evaluate current HCC surveillance strategies in HBV infection, focusing on risk stratification and advances in early detection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>English\u2010language literature published in PubMed and the Cochrane Database was comprehensively reviewed. This narrative review assessed the effectiveness of HCC surveillance strategies in HBV\u2010infected patients, with emphasis on recent advances in early\u2010stage HCC detection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This review summarizes viral, host and environmental factors associated with HCC susceptibility and evaluates current surveillance using ultrasound with or without alpha\u2010fetoprotein (AFP). Surveillance eligibility should follow guideline\u2010defined risk criteria: patients with an estimated annual HCC risk below 0.2% generally do not require routine surveillance and should undergo periodic risk reassessment, whereas patients meeting surveillance criteria should undergo ultrasound with or without AFP every 6\u2009months. Risk\u2010prediction scores can refine assessment but should be distinguished from early\u2010detection tests. GALAD, HES 2.0, multi\u2010target blood tests, and abbreviated magnetic resonance imaging are promising early\u2010detection approaches, but much of the supporting evidence derives from mixed\u2010aetiology or non\u2010HBV cohorts and prospective HBV\u2010specific validation remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A risk\u2010adapted approach should separate estimation of future HCC risk from surveillance and early\u2010detection testing. Guideline\u2010eligible patients should undergo surveillance every 6\u2009months, while emerging biomarker, imaging and artificial\u2010intelligence approaches remain adjunctive or investigational pending further HBV\u2010specific validation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.71008","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T08:04:30Z","timestamp":1790669070000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Review Article: Cancer Surveillance for Early Detection of Liver Cancer in Patients with HBV Infection"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7047-439X","authenticated-orcid":false,"given":"Andrew J.","family":"Park","sequence":"first","affiliation":[{"name":"College of Arts and Sciences Washington University  St Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bai L.","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Psychology Queens College  Queens New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4715-6865","authenticated-orcid":false,"given":"Xingfei","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases The Third Affiliated Hospital, Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6248-4117","authenticated-orcid":false,"given":"James","family":"Park","sequence":"additional","affiliation":[{"name":"Northwell Center for Liver Disease and Transplantation Northwell Health, Donald and Barbara Zucker School of Medicine at Hofstra and Northwell  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9801-2725","authenticated-orcid":false,"given":"Jiahong","family":"Dong","sequence":"additional","affiliation":[{"name":"Hepatobiliary and Pancreatic Center Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3723-6688","authenticated-orcid":false,"given":"Calvin Q.","family":"Pan","sequence":"additional","affiliation":[{"name":"Hepatobiliary and Pancreatic Center Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University  Beijing China"},{"name":"Division of Gastroenterology and Hepatology, Department of Medicine NYU Langone Health, NYU Grossman School of Medicine  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"issue":"12","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhepr.2025.101571","article-title":"Hepatocellular Carcinoma: Epidemiology, diagnosis and treatment","volume":"7","author":"Mauro E.","year":"2025","journal-title":"JHEP Reports"},{"issue":"10504","key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/S0140-6736(25)01042-6","article-title":"The Lancet Commission on Addressing the Global Hepatocellular Carcinoma Burden: Comprehensive Strategies From Prevention to Treatment","volume":"406","author":"Chan S. 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