{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:57:16Z","timestamp":1790686636886,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Predictive tools in autoimmune hepatitis (AIH) are scarce. A study proposed low ferritin and high IgG as prognostic markers for complete biochemical response (CBR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We aimed to externally validate the prognostic role of ferritin\u2010IgG score and its individual components in an independent multicentre AIH cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This multicentre study included 487 patients from the Hannover cohort (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009166) and the Spanish ColHai registry (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009321). Patients with ferritin &lt;\u20092.09\u00d7ULN received 1 point and those with IgG &gt;\u20091.89\u00d7ULN received 1 point, yielding a score of 0\u20132. Because baseline characteristics differed between cohorts, the score was additionally evaluated after inverse probability of treatment weighting (IPTW) propensity score.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At baseline, Hannover patients were younger (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005) and had higher transaminases, bilirubin (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), ferritin (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006) and IgG (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006). Overall, 79.7% achieved CBR; CBR rates were higher in ColHai at 6 (50.2% vs. 34.6%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) and 12\u2009months (67.6% vs. 51.9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). The score was associated with response in the Hannover cohort but showed no predictive capacity in ColHai (C\u2010statistic 0.51 [95% CI 0.45\u20130.56] at 6\u2009months; 0.51 [0.45\u20130.57] at 12\u2009months; 0.54 [0.47\u20130.61] at any time during the follow\u2010up). After IPTW, the score was not associated with CBR in the ColHai cohort (HR 0.86, 95% CI 0.67\u20131.10), whereas IgG retained its predictive value, with baseline levels &lt;\u20091.89\u00d7ULN associated with a higher probability of achieving CBR.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The ferritin\u2010IgG score failed external validation in an independent multicentre cohort. Ferritin showed no prognostic value, whereas the predefined IgG threshold retained its ability to predict treatment response.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.71014","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T04:41:22Z","timestamp":1790656882000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Revisiting Ferritin\u2010\n                    <scp>IgG<\/scp>\n                    Score to Predict Complete Biochemical Response in Autoimmune Hepatitis"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3610-2263","authenticated-orcid":false,"given":"\u00c1lvaro","family":"D\u00edaz\u2010Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"Gastroenterology and Hepatology Department Clinical and Translational Research in Digestive Diseases, Valdecilla Research Institute (IDIVAL), Marqu\u00e9s de Valdecilla University Hospital  Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0972-3454","authenticated-orcid":false,"given":"Bastian","family":"Engel","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology Hannover Medical School  Hannover Germany"},{"name":"European Reference Network on Hepatological Diseases (ERN RARE\u2010LIVER)  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3478-9981","authenticated-orcid":false,"given":"Manuel","family":"Hern\u00e1ndez\u2010Guerra","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital Universitario de Canarias  La Laguna Espa\u00f1a"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indhira","family":"P\u00e9rez\u2010Medrano","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Complejo Hospitalario Universitario de Pontevedra  Pontevedra Espa\u00f1a"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0326-4119","authenticated-orcid":false,"given":"Beatriz","family":"Mateos","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital Universitario Ram\u00f3n y Cajal, CIBERehd, IRYCIS  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9117-5049","authenticated-orcid":false,"given":"Rosa M.","family":"Morillas","sequence":"additional","affiliation":[{"name":"Hepatology Department Hospital Germans Trias i Pujol and Germans Trias i Pujol Research Institute, IGTP  Badalona Spain"},{"name":"Departament of Medicine Universitat Aut\u00f2noma de Barcelona, Centro de investigaci\u00f3n biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas, CIBERehd  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"G\u00f3mez","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital Universitario 12 de Octubre  Madrid Espa\u00f1a"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4923-7466","authenticated-orcid":false,"given":"Judith","family":"G\u00f3mez","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital Universitario de Burgos  Burgos Espa\u00f1a"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3675-1135","authenticated-orcid":false,"given":"Diana","family":"Horta","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital Universitari Mutua de Terrassa  Terrassa Espa\u00f1a"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Conde","sequence":"additional","affiliation":[{"name":"Hepatology and Liver Transplantation Unit Hospital Universitario y Polit\u00e9cnico La Fe, IIS La Fe  Valencia Spain"},{"name":"Ciberehd, ISCIII  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6276-7405","authenticated-orcid":false,"given":"Mar\u00eda Del","family":"Barrio","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Department Clinical and Translational Research in Digestive Diseases, Valdecilla Research Institute (IDIVAL), Marqu\u00e9s de Valdecilla University Hospital  Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0766-6864","authenticated-orcid":false,"given":"Ignasi","family":"Olivas","sequence":"additional","affiliation":[{"name":"European Reference Network on Hepatological Diseases (ERN RARE\u2010LIVER)  Hamburg Germany"},{"name":"Liver Unit Hospital Cl\u00ednic de Barcelona, Fundaci\u00f3 de Recerca Cl\u00ednic Barcelona\u2010Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (FRCB\u2010IDIBAPS), CIBERehd  Barcelona Espa\u00f1a"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7802-0920","authenticated-orcid":false,"given":"Ismael El","family":"Hajra","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital Universitario Puerta de Hierro Majadahonda  Madrid Espa\u00f1a"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9309-2052","authenticated-orcid":false,"given":"Mar","family":"Riveiro\u2010Barciela","sequence":"additional","affiliation":[{"name":"European Reference Network on Hepatological Diseases (ERN RARE\u2010LIVER)  Hamburg Germany"},{"name":"Liver Unit, Internal Medicine Department Hospital Universitari Vall D'hebron, Vall D'hebron Barcelona Hospital Campus  Barcelona Spain"},{"name":"CIBERehd, Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4368-8939","authenticated-orcid":false,"given":"Ana","family":"Barreira\u2010D\u00edaz","sequence":"additional","affiliation":[{"name":"Liver Unit, Internal Medicine Department Hospital Universitari Vall D'hebron, Vall D'hebron Barcelona Hospital Campus  Barcelona Spain"},{"name":"CIBERehd, Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7299-7143","authenticated-orcid":false,"given":"Carmen","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital Universitari Josep Trueta  Girona Espa\u00f1a"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9496-2133","authenticated-orcid":false,"given":"Carmen","family":"\u00c1lvarez\u2010Navasc\u00faes","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital Universitario Central de Asturias  Oviedo Espa\u00f1a"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1795-2919","authenticated-orcid":false,"given":"Manuel Rodr\u00edguez","family":"Per\u00e1lvarez","sequence":"additional","affiliation":[{"name":"Unidad de Hepatolog\u00eda y Trasplante Hep\u00e1tico, Hospital Universitario Reina Sof\u00eda, IMIBIC, CIBERehd  C\u00f3rdoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elmar","family":"Jaeckel","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology Hannover Medical School  Hannover 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Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.71014","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apt.71014","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.71014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:13:24Z","timestamp":1790684004000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.71014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,28]]},"references-count":23,"alternative-id":["10.1111\/apt.71014"],"URL":"https:\/\/doi.org\/10.1111\/apt.71014","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,28]]},"assertion":[{"value":"2025-10-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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