{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:49:19Z","timestamp":1792039759288,"version":"4.4.0"},"reference-count":77,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Socioeconomic and racial or ethnic inequalities affect colorectal cancer (CRC) across the care continuum. Although increasingly documented, whether current interventions effectively reduce these inequalities remains uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To review socioeconomic and racial or ethnic inequalities in CRC incidence, screening and diagnosis, treatment, surveillance and survival and assess interventions designed to reduce them.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a narrative review of adult studies published in English between January 2000 and March 2026. MEDLINE, EMBASE, PubMed, and ISI Web of Knowledge were searched for studies addressing socioeconomic or racial and ethnic disparities in CRC, using a saturation approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Socioeconomic disadvantage and belonging to some racial or ethnic minority groups were associated with higher CRC incidence within high\u2010income countries, lower screening participation, later diagnosis, less timely or guideline\u2010concordant treatment, poorer surveillance and worse survival. In the USA, five\u2010year survival was 60.6% among Black patients versus 66.7% among White patients, with little improvement in this gap over several decades. Inequalities at successive stages may contribute to cumulative disadvantage. Intervention evidence was markedly uneven across the continuum. Mailed stool\u2010test outreach and patient navigation increased screening among underserved populations, whereas evidence for interventions specifically reducing inequalities in treatment, surveillance, and broader survivorship was sparse.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Improving overall CRC prevention and care cannot be assumed to reduce inequalities. The major evidence gap has shifted from documenting disparities towards demonstrating how to reduce them, particularly beyond screening. Equity should become an explicit outcome of CRC research, implementation, healthcare quality assessment and clinical guidelines.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.71021","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:36:29Z","timestamp":1792038989000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Review Article: Socioeconomic and Racial or Ethnic Inequalities Across the Colorectal Cancer Continuum: From Disparities to Action"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0028-1837","authenticated-orcid":false,"given":"Marc","family":"Bardou","sequence":"first","affiliation":[{"name":"Centre D'investigation Clinique 1432 unit\u00e9 Plurith\u00e9matique Universit\u00e9 Bourgogne Europe, CHU Dijon Bourgogne  Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Martel","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Biostatistics and Occupational Health McGill University  Montr\u00e9al Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1798-5526","authenticated-orcid":false,"given":"Alan N.","family":"Barkun","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology McGill University Health Centre  Montr\u00e9al Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4834-9693","authenticated-orcid":false,"given":"Nicolas","family":"Chapelle","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Digestive Diseases Institute, CHU de Nantes  Nantes France"},{"name":"Centre for Research in Transplantation and Translational Immunology, UMR 1064, ITUN5 INSERM  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"issue":"3","key":"e_1_2_11_2_1","first-page":"209","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung H.","year":"2021","journal-title":"CA: A Cancer Journal for Clinicians"},{"issue":"2","key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1136\/gutjnl-2022-327736","article-title":"Global Burden of Colorectal Cancer in 2020 and 2040: Incidence and Mortality Estimates From GLOBOCAN","volume":"72","author":"Morgan E.","year":"2023","journal-title":"Gut"},{"issue":"4","key":"e_1_2_11_4_1","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1097\/CEJ.0000000000000326","article-title":"Socioeconomic Status and Site\u2010Specific Cancer Incidence, a Bayesian Approach in a French Cancer Registries Network Study","volume":"27","author":"Bryere J.","year":"2018","journal-title":"European Journal of Cancer Prevention"},{"key":"e_1_2_11_5_1","unstructured":"Cancer Research UK \u201cBowel Cancer Statistics\u201d https:\/\/wwwcancerresearchukorg\/health\u2010professional\/cancer\u2010statistics\/statistics\u2010by\u2010cancer\u2010type\/bowel\u2010cancer\/incidence#heading\u2010Five."},{"issue":"2","key":"e_1_2_11_6_1","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1053\/j.gastro.2019.10.029","article-title":"Causes of Socioeconomic Disparities in Colorectal Cancer and Intervention Framework and Strategies","volume":"158","author":"Carethers J. 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