{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T05:51:17Z","timestamp":1791611477827,"version":"4.3.4"},"reference-count":43,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","award":["NIHR305654"],"award-info":[{"award-number":["NIHR305654"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Wales has the highest rate of colorectal cancer (CRC) in the UK. National guidelines recommend using the faecal immunochemical test (FIT) in patients presenting with symptoms of bowel cancer. FIT \u2265\u200910\u2009\u03bcgHb\/g in symptomatic patients is presumed to indicate a &gt;\u20093% risk of CRC. However, evidence from England and Scotland has found that the risk is lower in certain demographic groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To examine 1\u2010year risk of CRC in Welsh patients with symptoms of suspected bowel cancer by demographics, iron deficiency anaemia (IDA), and FIT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Cohort study of adults registered in the Welsh Longitudinal General Practice dataset with a FIT recorded from 01\/01\/2020\u201331\/03\/2024. Kaplan\u2013Meier estimates were used to calculate 1\u2010year cumulative risks of CRC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 166,863 patients with a FIT; 19.2% had a FIT \u2265\u200910\u2009\u03bcgHb\/g. Within 1\u2009year, 2864 (1.72%) were diagnosed with CRC; 90.2% of which were following FIT\u2009\u2265\u200910\u03bcgHb\/g. A FIT cut\u2010off of \u2265\u200910\u2009\u03bcgHb\/g in isolation identified a &gt;\u20093% risk of CRC across all age groups. In those with FIT\u2009\u2265\u200910\u03bcgHb\/g, IDA resulted in an increase in predicted risk across all age groups. IDA aided stratification further in women &lt;\u200950\u2009years; risk of CRC was 6.45% (95% CI: 3.52\u20139.29) with a FIT \u2265\u200910\u2009\u03bcgHb\/g and IDA compared to 2.20% (95% CI: 1.57\u20132.83) without IDA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In Wales, the risk of CRC following FIT\u2009\u2265\u200910\u2009\u03bcgHb\/g is higher than observed in English and Scottish cohorts. Stratification by demographics and blood results identified those at highest risk, but this did not fully explain the higher baseline risk observed in comparison to other UK nations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.71028","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T05:32:09Z","timestamp":1791610329000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Population\u2010Based Cohort Study: Colorectal Cancer Risk Stratification in Symptomatic Patients Using the Faecal Immunochemical Test, Blood Results and Patient Characteristics in Wales"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4114-126X","authenticated-orcid":false,"given":"Francesca Ligori","family":"Malcolm","sequence":"first","affiliation":[{"name":"Colorectal Service, Nottingham University Hospitals NHS Trust Queen's Medical Centre  Nottingham UK"},{"name":"School of Medicine University of Nottingham, Queen's Medical Centre  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6794-6621","authenticated-orcid":false,"given":"Colin J.","family":"Crooks","sequence":"additional","affiliation":[{"name":"School of Medicine University of Nottingham, Queen's Medical Centre  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1135-9356","authenticated-orcid":false,"given":"Joe","family":"West","sequence":"additional","affiliation":[{"name":"Lifespan and Population Health, School of Medicine University of Nottingham  Nottingham UK"},{"name":"Department of Clinical Medicine\u2014Hepatology and Gastroenterology Aarhus University Hospital  Aarhus N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1990-5948","authenticated-orcid":false,"given":"Manpreet","family":"Bains","sequence":"additional","affiliation":[{"name":"Lifespan and Population Health, School of Medicine University of Nottingham  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliann","family":"Fairbairn","sequence":"additional","affiliation":[{"name":"Colorectal Service, Nottingham University Hospitals NHS Trust Queen's Medical Centre  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff","family":"Turner","sequence":"additional","affiliation":[{"name":"National Endoscopy Programme, Performance and Improvement NHS Wales  Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Hughes","sequence":"additional","affiliation":[{"name":"Digital Health and Care Wales NHS Wales  Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynnette","family":"Jones","sequence":"additional","affiliation":[{"name":"Patient and Public Involvement Contributor, Nottingham University Hospitals NHS Trust Queen's Medical Centre  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7071-4098","authenticated-orcid":false,"given":"David J.","family":"Humes","sequence":"additional","affiliation":[{"name":"Colorectal Service, Nottingham University Hospitals NHS Trust Queen's Medical Centre  Nottingham UK"},{"name":"School of Medicine University of Nottingham, Queen's Medical Centre  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"Spotlight on Bowel Cancer in Wales: Early Diagnosis Saves Live","author":"Bowel Cancer UK","year":"2018"},{"issue":"10539","key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1016\/S0140-6736(26)00418-6","article-title":"Announcing the Lancet Commission on Colorectal Cancer: Addressing the Rising Global Burden","volume":"407","author":"Cercek A.","year":"2026","journal-title":"Lancet"},{"key":"e_1_2_11_4_1","unstructured":"Cancer Research UK \u201cBowel Cancer Incidence 2025 \u201d2025 accessed 4 March 2026 https:\/\/crukcancerintelligence.shinyapps.io\/CancerStatsDataHub\/_w_18c14b11e72149b5a23bb3459af55b00\/_w_55971ec7d9fa4b26a95a0b5b53fcb213\/?_inputs_&nav=%22Incidence%20Breakdowns%20and%20Trends%22&app_select_CancerSite=%22Bowel%22&app_select_Country=%22Wales%22."},{"key":"e_1_2_11_5_1","unstructured":"National Cancer Audit Collaborating Centre \u201cNational Bowel Cancer Audit: State of the Nation Report. 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