{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T22:49:27Z","timestamp":1791672567728,"version":"4.3.4"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:00:00Z","timestamp":1790985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:00:00Z","timestamp":1790985600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Potassium\u2010competitive acid blockers provide rapid and sustained acid suppression, but tegoprazan has not been studied in non\u2010Asian populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To compare the efficacy and safety of tegoprazan 50\u2009mg once daily with pantoprazole 40\u2009mg once daily for healing erosive oesophagitis and improving reflux symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this multicentre, randomized, double\u2010blind, active\u2010controlled trial, Mexican adults with Los Angeles grade B\u2013D erosive oesophagitis received tegoprazan or pantoprazole for 4\u2009weeks. The primary outcome was superior endoscopic healing at week 4. Secondary outcomes included early symptom response, complete symptom resolution, changes in symptom severity, health\u2010related quality of life, and adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seventy participants were randomized and 64 completed treatments. In the intention\u2010to\u2010treat population, endoscopic healing occurred in 88.9% receiving tegoprazan and 79.4% receiving pantoprazole (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.33). In the per\u2010protocol population, healing occurred in 100% and 84.4%, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.053). Among participants with Los Angeles grade C or D oesophagitis, per\u2010protocol healing rates were 100% with tegoprazan and 68.8% with pantoprazole (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04). During the first treatment week, at least 50% symptom improvement occurred in 84.4% and 31.3%, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and complete symptom resolution was more frequent with tegoprazan from day 1. Symptom severity and health\u2010related quality of life improved in both groups. Adverse events were infrequent, mild, and unrelated to treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>There was a nonsignificant 9.5% difference in the primary intention\u2010to\u2010treat 4\u2010week healing endpoint between tegoprazan and pantoprazole. Tegoprazan provided faster symptom improvement, while the per\u2010protocol findings and the higher healing rate observed in the exploratory severe oesophagitis subgroup were encouraging and warrant further investigation. (ClinicalTrials.gov Identifier: NCT06991348).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.71032","type":"journal-article","created":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T03:36:55Z","timestamp":1791085015000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The\n                    <scp>TOP<\/scp>\n                    \u2010\n                    <scp>GERD<\/scp>\n                    Trial: Comparative Efficacy of Tegoprazan Versus Pantoprazole in the Treatment of Erosive Oesophagitis in a Non\u2010Asian Population"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8478-9659","authenticated-orcid":false,"given":"Jos\u00e9 M.","family":"Remes\u2010Troche","sequence":"first","affiliation":[{"name":"Medical Biological Research Institute Universidad Veracruzana  Veracruz Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1759-4218","authenticated-orcid":false,"given":"Luis Ra\u00fal","family":"Valdovinos\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Medica Sur  Mexico City Mexico"},{"name":"Gastrologen  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3388-0660","authenticated-orcid":false,"given":"C. Prakash","family":"Gyawali","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2069-5794","authenticated-orcid":false,"given":"Jos\u00e9 Luis","family":"Vargas\u2010Basurto","sequence":"additional","affiliation":[{"name":"Medical Biological Research Institute Universidad Veracruzana  Veracruz Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9921-3590","authenticated-orcid":false,"given":"Carlos Alberto","family":"Reyes\u2010Medina","sequence":"additional","affiliation":[{"name":"Medical Division Laboratorios Carnot  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisselle Vanessa","family":"Gonz\u00e1lez\u2010Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Medical Division Laboratorios Carnot  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Rafael Bernal","family":"Mendez","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. H. Barrag\u00e1n","family":"Cordova","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Thomas\u2010Dupont","sequence":"additional","affiliation":[{"name":"Medical Biological Research Institute Universidad Veracruzana  Veracruz Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9998-7324","authenticated-orcid":false,"given":"Peter","family":"Grube\u2010Pagola","sequence":"additional","affiliation":[{"name":"Medical Biological Research Institute Universidad Veracruzana  Veracruz Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20101253(19)30408\u2010X"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001538"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14075"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2022.01.025"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894\u2010024\u201000939\u20103"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.16295"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.118.254904"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15438"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2017.05.306"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15185"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.17255"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14969"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000003276"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2025.1675457"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102016\u2010313589"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.2015"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.45.2.172"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102023\u2010330616"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000002352"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655298750026697"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442\u20102050.2007.00658.x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.83302"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.71032","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apt.71032","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.71032","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T22:13:47Z","timestamp":1791670427000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.71032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,3]]},"references-count":22,"alternative-id":["10.1111\/apt.71032"],"URL":"https:\/\/doi.org\/10.1111\/apt.71032","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,3]]},"assertion":[{"value":"2026-07-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"apt.71032"}}