{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T03:43:48Z","timestamp":1792554228012,"version":"4.5.0"},"reference-count":53,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004046","name":"Karen Elise Jensens Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004046","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI139126"],"award-info":[{"award-number":["R01AI139126"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Evidence concerning gastrointestinal cancer risk after eosinophilic oesophagitis (EoE) diagnosis is limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To examine the association between EoE and incident gastrointestinal cancer in a population\u2010based cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using nationwide Danish health registries, we identified all patients diagnosed with EoE between 1997 and 2024, using a validated algorithm. We computed standardised incidence ratios (SIRs) for gastrointestinal cancers overall and site\u2010specific cancers compared with the general population. To distinguish short\u2010term diagnostic activity from longer\u2010term risk, we stratified analyses by &lt;\u20091 and \u2265\u20091\u2009year after EoE diagnosis. Secondary analyses examined oesophageal cancer incidence among EoE patients with coexisting Barrett's oesophagus (BE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 9115 EoE patients, 170 developed gastrointestinal cancers. During the first year after EoE diagnosis, the SIR was 2.83 (95% confidence interval: 2.10\u20133.74). Beyond 1\u2009year, the overall SIR attenuated (1.03 [0.85\u20131.23]) but remained elevated for oesophageal cancer (2.40 [1.42\u20133.79]) and hepatocellular carcinoma (2.05 [0.98\u20133.77]). Among patients who developed oesophageal cancer \u2265\u20091\u2009year after EoE diagnosis (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200918), most had prior BE. The SIR for oesophageal cancer was 5.44 (2.90\u20139.31) among patients with both EoE and BE and 4.84 (4.36\u20135.37) among patients with BE alone. SIR for patients with EoE alone could not be reported due to the low number of cancer cases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>One year after EoE diagnosis, oesophageal cancer and hepatocellular carcinoma rates remained elevated. Most oesophageal cancers occurred in patients with prior BE, suggesting that the association between EoE and oesophageal cancer may be mediated largely through BE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.71061","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T03:28:48Z","timestamp":1792553328000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Eosinophilic Oesophagitis and Incidence of Gastrointestinal Cancer: A Population\u2010Based Cohort Study"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8778-6427","authenticated-orcid":false,"given":"Gencer","family":"Kurt","sequence":"first","affiliation":[{"name":"Department of Clinical Epidemiology Center for Population Medicine, Aarhus University and Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Surgery Randers Regional Hospital  Randers 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Gastroenterology and Hepatology, Department of Medicine University of North Carolina School of Medicine  Chapel Hill North Carolina USA"},{"name":"Department of Epidemiology and Prevention Wake Forest School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4299-7040","authenticated-orcid":false,"given":"Henrik Toft","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Center for Population Medicine, Aarhus University and Aarhus University Hospital  Aarhus Denmark"},{"name":"Center for Esophageal Diseases and Swallowing, Division of Gastroenterology and Hepatology, Department of Medicine University of North Carolina School of Medicine  Chapel Hill North Carolina 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