{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T04:37:24Z","timestamp":1792730244134,"version":"4.5.0"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Reported outcomes after gastrointestinal bleeding (GIB) in anticoagulated patients are inconsistent, and comparisons with non\u2010anticoagulated patients are limited. We assessed whether anticoagulation status was independently associated with mortality after GIB and identified predictors of death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We analysed 11,387 consecutive adults with acute GIB over 25\u2009years (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009500 direct oral anticoagulant [DOAC],\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009353 warfarin,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200910,534 non\u2010anticoagulated). All\u2010cause mortality at 30\u2009days and 1\u2009year was modelled using overlap\u2010weighted logistic regression, with complete mortality follow\u2010up through the Israeli National Population Registry.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Anticoagulated patients were older (median age 81.7 [DOAC] and 75.1 [warfarin] vs. 58.4\u2009years), had greater comorbidity and higher crude mortality than non\u2010anticoagulated patients. After overlap weighting, neither DOAC nor warfarin was significantly associated with mortality (30\u2010day OR 1.61, 95% CI 0.81\u20133.21 for DOAC and 1.30, 95% CI 0.56\u20133.02 for warfarin; 1\u2010year OR 0.90, 95% CI 0.62\u20131.31 and 1.08, 95% CI 0.69\u20131.69). At 30\u2009days, mortality was associated with age, haemodynamic shock (OR 4.25) and Internal Medicine ward admission (OR 4.55); at 1\u2009year, with age, renal failure, Internal Medicine ward admission and inversely with male sex. Anticoagulation was resumed at discharge in 37.8% of survivors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Neither DOAC nor warfarin was significantly associated with 30\u2010day or 1\u2010year mortality after GIB, including when bleeding severity and admitting ward were excluded from the outcome model. Thirty\u2010day mortality was associated with severity at presentation, whereas 1\u2010year mortality was associated with underlying patient characteristics. Resumption was not significantly associated with mortality or readmission for recurrent bleeding.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.71063","type":"journal-article","created":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:38:58Z","timestamp":1792726738000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Beyond Anticoagulant Exposure: Determinants of Mortality After Gastrointestinal Bleeding Across\n                    <scp>DOAC<\/scp>\n                    , Warfarin and Non\u2010Anticoagulated Patients"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7223-9913","authenticated-orcid":false,"given":"Esther","family":"Forkosh","sequence":"first","affiliation":[{"name":"Institute of Gastroenterology and Hepatology, Hadassah Medical Center, and Faculty of Medicine Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Hakimian","sequence":"additional","affiliation":[{"name":"Institute of Gastroenterology and Hepatology, Hadassah Medical Center, and Faculty of Medicine Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harold","family":"Jacob","sequence":"additional","affiliation":[{"name":"Institute of Gastroenterology and Hepatology, Hadassah Medical Center, and Faculty of Medicine Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian M.","family":"Gralnek","sequence":"additional","affiliation":[{"name":"Rappaport Faculty of Medicine Technion\u2014Israel Institute of Technology  Haifa Israel"},{"name":"Ellen and Pinchas Mamber Institute of Gastroenterology and Hepatology Emek Medical Center  Afula Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2885-7279","authenticated-orcid":false,"given":"Lior","family":"Katz","sequence":"additional","affiliation":[{"name":"Institute of Gastroenterology and Hepatology, Hadassah Medical Center, and Faculty of Medicine Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aviv","family":"Talmon","sequence":"additional","affiliation":[{"name":"Allergy and Clinical Immunology Unit, Department of Medicine, Hadassah Medical Center, and Faculty of Medicine The Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta21090"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.4140\/TCP.n.2015.644"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.15466"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/dj4010005"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.12.018"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11239\u2010021\u201002416\u20104"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt\u20102021\u2010001737"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h1585"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325\u2010022\u201002333\u20109"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.7326\/M21\u20101474"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000001796"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.7326\/M22\u20100511"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.10.037"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.05.017"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000002148"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.15476"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl\u20102024\u2010324763"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620\u2010026\u201009774\u20100"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlr.0000182534.19832.83"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.7819"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2019.07.012"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.70329"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.04.053"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.13442"}],"container-title":["Alimentary Pharmacology &amp; 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