{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:10:48Z","timestamp":1767651048287},"reference-count":9,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,10,28]],"date-time":"2013-10-28T00:00:00Z","timestamp":1382918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asian J Endoscop Surgery"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report a rare case of thymic metastasis of breast cancer. A 68\u2010year\u2010old woman, who had undergone surgery for cancer in her right breast and had been free of recurrence for 22 years, was noted to have an abnormal shadow on a chest X\u2010ray at a regular medical checkup. Further workup, including chest <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>, revealed a 22\u2009\u00d7\u200918\u2010mm mass in the anterior mediastinum. Fluorine\u201018\u2010fluorodeoxyglucose\u2010<jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content> showed increased fluorine\u201018\u2010fluorodeoxyglucose uptake that was highly suggestive of thymoma. Thoracoscopic thymothymectomy was performed. The tumor had invaded the pericardium, which was also resected. A small nodule was found in the right lung, and it was also resected. The intraoperative frozen\u2010section diagnosis was breast cancer metastasis to the thymus and lung. The pathological diagnosis was luminal A solid tubular carcinoma (strongly estrogen receptor and progesterone receptor positive, <jats:styled-content style=\"fixed-case\">HER2<\/jats:styled-content> negative) with an <jats:styled-content style=\"fixed-case\">MIB<\/jats:styled-content>\u20101 index of less than 5%. After surgery, the patient was treated with an aromatase inhibitor. As of August 2013, she has been free of recurrence for more than 36 months. It is extremely rare for breast cancer to metastasize to the thymus more than 20 years after surgery.<\/jats:p>","DOI":"10.1111\/ases.12060","type":"journal-article","created":{"date-parts":[[2013,10,28]],"date-time":"2013-10-28T09:29:07Z","timestamp":1382952547000},"page":"330-332","source":"Crossref","is-referenced-by-count":5,"title":["Thymic metastasis of breast cancer 22 years after surgery: A case report"],"prefix":"10.1111","volume":"6","author":[{"given":"Shinji","family":"Fujioka","sequence":"first","affiliation":[{"name":"Division of General Thoracic Surgery Tottori University Hospital  Yonago Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshige","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Division of General Thoracic Surgery Tottori University Hospital  Yonago Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Miwa","sequence":"additional","affiliation":[{"name":"Division of General Thoracic Surgery Tottori University Hospital  Yonago Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuzo","family":"Takagi","sequence":"additional","affiliation":[{"name":"Division of General Thoracic Surgery Tottori University Hospital  Yonago Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohei","family":"Yurugi","sequence":"additional","affiliation":[{"name":"Division of General Thoracic Surgery Tottori University Hospital  Yonago Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"Division of General Thoracic Surgery Tottori University Hospital  Yonago Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyosuke","family":"Ishiguro","sequence":"additional","affiliation":[{"name":"Division of Breast Surgery Tottori University Hospital  Yonago Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,28]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1966.6"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2007.8.4.360"},{"key":"e_1_2_5_4_1","first-page":"56","article-title":"A case of breast metastasis to the intra\u2010thymic lymph node diagnosed by partial resection of the thymus using video\u2010assisted thoracoscopic surgery","volume":"20","author":"Sakaguchi M","year":"2006","journal-title":"Nihon Kokyuki Geka Gakkai Zasshi (Jpn J Chest Surg)"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001100303"},{"key":"e_1_2_5_6_1","first-page":"3445","article-title":"Clinicopathological characteristics of recurrence more than 10 years after surgery in patients with breast carcinoma","volume":"29","author":"Takeuchi H","year":"2009","journal-title":"Anticancer Res"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.3919\/jjsa.69.2804"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27579"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-005-1901-1"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.14.3357"}],"container-title":["Asian Journal of Endoscopic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fases.12060","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ases.12060","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T14:53:34Z","timestamp":1696344814000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ases.12060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,28]]},"references-count":9,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["10.1111\/ases.12060"],"URL":"https:\/\/doi.org\/10.1111\/ases.12060","archive":["Portico"],"relation":{},"ISSN":["1758-5902","1758-5910"],"issn-type":[{"value":"1758-5902","type":"print"},{"value":"1758-5910","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,28]]}}}