{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T14:02:29Z","timestamp":1749132149821},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,2,11]],"date-time":"2015-02-11T00:00:00Z","timestamp":1423612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asian J Endoscop Surgery"],"published-print":{"date-parts":[[2015,5]]},"abstract":"Abstract<\/jats:title>Introduction<\/jats:title>Postoperative abnormal liver function tests (LFT<\/jats:styled-content>) following laparoscopic cholecystectomy (LC<\/jats:styled-content>) could present a substantial clinical dilemma due to suspicion of missed choledocholithiasis or more serious complications such as bile duct injury. We noted that LFT<\/jats:styled-content> were more likely to be abnormal when an intraoperative cholangiogram (IOC<\/jats:styled-content>) had been performed. This study aims to examine if contrast injection into the biliary tract during IOC<\/jats:styled-content> is associated with deranged LFT<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>Data on all LC<\/jats:styled-content> performed in a tertiary referral hospital network over a period of 30 months were collected retrospectively, and two groups were identified depending on successful performance of an IOC<\/jats:styled-content>. Identical inclusion and exclusion criteria were applied to both groups to identify eligible patients. Alkaline phosphatase, gamma\u2010glutamyl transferase (GGT<\/jats:styled-content>), alanine transaminase (ALT<\/jats:styled-content>), and bilirubin levels were recorded, and the mean difference between preoperative and postoperative values was analyzed.<\/jats:p><\/jats:sec>Results<\/jats:title>There were 177 eligible patients: 147 patients in the LC<\/jats:styled-content> with IOC<\/jats:styled-content> test group (IOC<\/jats:styled-content> group) and 30 patients in the LC<\/jats:styled-content> without IOC<\/jats:styled-content> control group (NO IOC<\/jats:styled-content> group). Demographics and preoperative mean LFT<\/jats:styled-content> were not significantly different between groups. In the IOC<\/jats:styled-content> group, the mean ALT<\/jats:styled-content> difference (43\u2009\u00b1\u200957, P<\/jats:italic>\u2009=<\u20090.001) and GGT<\/jats:styled-content> difference (34\u2009\u00b1\u200966, P<\/jats:italic>\u2009=<\u20090.001) were significantly higher than in the NO IOC<\/jats:styled-content> group (ALT<\/jats:styled-content> [19\u2009\u00b1\u200925], GGT<\/jats:styled-content> [7\u2009\u00b1\u200920]). The mean alkaline phosphatase difference (IOC<\/jats:styled-content> [9\u2009\u00b1\u200947], NO IOC<\/jats:styled-content> [\u22122\u2009\u00b1\u200914], P<\/jats:italic>\u2009=\u20090.214) and mean bilirubin difference (IOC<\/jats:styled-content> [\u22122\u2009\u00b1\u20099], NO IOC<\/jats:styled-content> [\u22121\u2009\u00b1\u20098], P<\/jats:italic>\u2009=\u20090.911) were not significantly different.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The performance of an IOC<\/jats:styled-content> is associated with elevated GGT<\/jats:styled-content> and ALT<\/jats:styled-content> but does not affect alkaline phosphatase and bilirubin concentrations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ases.12174","type":"journal-article","created":{"date-parts":[[2015,2,13]],"date-time":"2015-02-13T07:09:44Z","timestamp":1423811384000},"page":"158-163","source":"Crossref","is-referenced-by-count":2,"title":["Effect of contrast injection into the biliary tract during intraoperative cholangiogram on postoperative liver function tests"],"prefix":"10.1111","volume":"8","author":[{"given":"Chandika","family":"Wewelwala","sequence":"first","affiliation":[{"name":"Department of Upper GI\/HPB Surgery Monash Health Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Cashin","sequence":"additional","affiliation":[{"name":"Department of Upper GI\/HPB Surgery Monash Health Melbourne Victoria Australia"},{"name":"Department of Surgery Monash University Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Blamey","sequence":"additional","affiliation":[{"name":"Department of Upper GI\/HPB Surgery Monash Health Melbourne Victoria Australia"},{"name":"Department of Surgery Monash University Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Gribbin","sequence":"additional","affiliation":[{"name":"Department of Upper GI\/HPB Surgery Monash Health Melbourne Victoria Australia"},{"name":"Department of Surgery Monash University Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Low","sequence":"additional","affiliation":[{"name":"Department of Upper GI\/HPB Surgery Monash Health Melbourne Victoria Australia"},{"name":"Department of Surgery Monash University Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Croagh","sequence":"additional","affiliation":[{"name":"Department of Upper GI\/HPB Surgery Monash Health Melbourne Victoria Australia"},{"name":"Department of Surgery Monash University Melbourne Victoria 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