{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T05:54:54Z","timestamp":1768974894304,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,12,22]],"date-time":"2016-12-22T00:00:00Z","timestamp":1482364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asian J Endoscop Surgery"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Accidental gallbladder perforation frequently occurs during laparoscopic cholecystectomy and may increase the risk of infection. However, the necessity of antimicrobial prophylaxis for these patients is unclear. The aim of this study was to examine the clinical outcomes and necessity of antimicrobial prophylaxis after laparoscopic cholecystectomy with gallbladder perforation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred patients who underwent laparoscopic cholecystectomy were divided into two groups: patients with gallbladder perforation (Group A, <jats:italic>n<\/jats:italic>\u00a0=\u00a037) and patients without perforation (Group B, <jats:italic>n<\/jats:italic>\u00a0=\u00a063). We compared the white blood cell count and C\u2010reactive protein level the day after the operation, the complication rates of systemic inflammatory response syndrome and surgical\u2010site infection, and postoperative hospital stay between the two groups. All patients received antimicrobial prophylaxis only once before the operation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were significant differences in every variable with the exception of postoperative hospital stay. Group A had a higher risk of infection, but the postoperative clinical course of Group A was not inferior to that of Group B.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The clinical outcomes of patients with accidental gallbladder perforation were acceptable, and the use of antimicrobial prophylaxis once before the operation was sufficient.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ases.12348","type":"journal-article","created":{"date-parts":[[2016,12,24]],"date-time":"2016-12-24T15:17:27Z","timestamp":1482592647000},"page":"162-165","source":"Crossref","is-referenced-by-count":11,"title":["Clinical outcomes of laparoscopic cholecystectomy with accidental gallbladder perforation"],"prefix":"10.1111","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3404-1145","authenticated-orcid":false,"given":"Teruyuki","family":"Usuba","sequence":"first","affiliation":[{"name":"Department of Surgery Machida Municipal Hospital  Tokyo 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